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MOLECULAR IMMUNOLOGICAL STUDIES ON ITRACTABLE UVEITIS FREQUENTLY SEEN IN JAPAN.

Research Project

Project/Area Number 05671472
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionYokohama City University

Principal Investigator

OHNO Shigeaki  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE PROFESSOR, 医学部, 教授 (50002382)

Co-Investigator(Kenkyū-buntansha) UCHIO Eiichi  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE ASSISTANT, 医学部, 助手 (70232840)
KUMAGAI Naoki  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (20234510)
NAKAMURA Satoshi  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (00237398)
磯部 裕  横浜市立大学, 医学部, 助教授 (30193402)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsUVEITIS / BEHCET'S DISEASE / VOGT-KOYANAGI-HARADA'S DISEASE / HLA / MOLECULAR BIOLOGY / IMMUNOGENETICS / 難治性ぶどう膜炎 / サルコイドーシス / 分子遺伝学 / 分子免疫学 / 実験的自己免疫性網膜ぶどう膜炎
Research Abstract

1.Behcet's disease is known to be associated with HLA-B51. In this study, in order to identify new gene (s) related to this disease, we screened the Y109YAC clone containing HLA-B and -C genes and subcloned into pWE15 cosmid vector. As a result, the Y109 YAC clone turned out to be chimeric and about 240 kb are consisting of the chromosome 6 region and remaining 360 kb are consisting of the chromosome 7 region. We have screened the skin fibroblast cDNA library using pM38 cosmid clone as a probe and isolated one cDNA clone. This cDNA clone was recognized to be located on the 1.9kb EcoRl fragment of the pM38 cosmid clone between the MICA and HLA-B genes. Northern hybridization showed approximately 10 kb transcript in the heart, brain, placenta, lung, liver and kidney, and 3kb transcript in the skeletal muscle. Shot-gun sequencing of the cosmid pM56 revealed to be 39,164bp in length and contained as much as 39 Alu-like sequences. Homology search for the up-to date DNA data base showed five regions highly homologous to reported DNAs. Computer analysis of these anonymous genomic sequences reveals the existence of potential coding sequences and the possibility that they are strong candidate genes for determining the pathogenesis of Behcet's disease.
2.For the molecular immunological studies of Vogt-Koyanagi-Harada's disease, flowcytometric analysis were done using the aqueous humor lymphocytes and cerebrospinal fluid lymphocytes. It was revealed that memory T cells, as well as activated T lymphocytes were significantly elevated as compared with those in the peripheral blood. Therefore, these cells play main immunological roles in the immunopathogenesis of this disease.
3.In conclusion, in this study, molecular immunological mechanisms of the intractable endogenous uveitis syndromes were further investigated. Molecular genetic susceptibility to these diseases, and T cell-mediated immune mechanism possibly lead to the future genetic diagnosis and gene therapy.

Report

(2 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • Research Products

    (111 results)

All Other

All Publications (111 results)

  • [Publications] 熊谷直樹: "アレルギー性疾患の病態・診断・治療 アレルギー性結膜炎" 最新医学 臨時増刊号. 131-143 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 新藤裕実子: "ライム病" 臨床眼科. 48. 123-129 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 水木信久: "Behcet病の免疫遺伝学的解析" 医学のあゆみ. 168. 723-725 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 深見玲子: "内因性ぶどう膜炎患者の血清adenosine deaminase活性およびangiotensin converting enzyme 活性" 日本眼科学会雑誌. 98. 287-292 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 臼井正彦: "Ketorolac trometamol(RS-37619)点眼液の前部ぶどう膜炎に対する第III相試験-Pranoprofen点眼液を対照とした二重盲検群間比較試験-" 眼科臨床医報. 88. 185-196 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shindo Y: "HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RFLP and the strong association with DRB1 0405 and DRB1 0410" British Journal of Ophthalmology. 78. 223-226 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松本覚: "花粉症の眼の症状" MEDICO. 25. 9-11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishioka M: "FK 506 treatment of nonifections uveitis" Am J Ophthalmol. 118. 723-729 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 中川尚: "ELISA法(アデノクロン)によるアデノウイルス結膜炎の迅速診断" 日本の眼科. 65. 13-18 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 石岡みさき: "FK 506治療中に痙攣発作を生じたベーチェット病の1例" 眼科. 36. 695-697 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Goto K.,: "HTLV-I seroprevalence in patients with undefined uveitis in central Japan" Jpn J Ophthalmol. 38. 175-177 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 青木功喜: "眼科感染症サーベイランス情報" 日本の眼科. 65. 345- (1994)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shindo Y: "Complete association of the HLA-DRB1 04 and-DQB1 04 alleles with Vogt-Koyanagi-Harada's disease" Hum Immunol. 39. 169-176 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 杉浦奈保美: "眼部帯状ヘルペスの臨床像と病型" 臨床眼科. 48. 346-347 (1994)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松本年弘: "シクロスポリン点眼が奏効したWegener肉芽腫症による強角膜潰瘍の1例" 臨床眼科. 48. 350-351 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 新藤裕実子: "自己免疫疾患の眼病変とその治療" 臨床医. 20. 69-71 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高倉保雄: "アトピー性皮膚炎に伴った網膜剥離" 眼科臨床医報. 88. 90-91 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 石原麻美: "サルコイドーシスにおける疾患感受性因子の検討" 日眼会誌. 98. 80-85 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishihara M.: "Molecular genetic studies of HLA class II alleles in sarcoidosis" Tissue Antigens. 43. 238-241 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Uchio E: "Suppression of experimental uveitis with monoclonal antibodies to ICAM-1 and LFA-1" Invest Ophthalmol Vis Sci. 35. 2626-2631 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi T: "Central nervous system toxicity related to FK506 in patients with Behcet's disease" Ann Rheum Dis. 53. 350-351 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Isogai E.: "Lyme disease Spirochetes in a wild fox(Vulpes vulpes schrencki)and in Ticks" J Wildl Dis. 30. 439-444 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 杉田美由紀: "ぶどう膜炎の臨床像と治療" 日本の眼科. 65. 919-921 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 中尾久美子: "HTLV-I associated uveitisの疫学と臨床に関する他施設共同研究" 日本眼科学会雑誌. 98. 858-865 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森博之: "網膜色素上皮症の疫学的検討" 臨眼. 48. 938-939 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "副腎皮質ステロイド薬の全身投与法" 日本の眼科. 65. 779- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 吉川麻里: "ベーチェット病の治療におけるFK506とシクロスポリンの比較" 臨眼. 48. 1196-1197 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木克也: "内因性ぶどう膜炎におけるChlamydia pneumoiae" 臨眼. 48. 1208-1209 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizuki N: "A complete type patient with Behcet's disease associated with HLA-B 5102" Acta Ophthalmol. 72. 757-758 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 花尻真智子: "皮疹のない眼部帯状発疹" 臨眼. 48. 658-660 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Uchio E: "A retrospective study of herpes simplex keratitis over the last 30 years" Jpn J Ophthalmol. 38. 196-201 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "難治性ぶどう膜炎(ベーチェット病、原田病)における人類遺伝学的分子生物学的発症機構の解析" 日中医学. 9. 5-8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 中村聡: "Current Encyclopedia of Ophthalmology" 強直性脊椎炎、HLA-B27,Reiter病によるぶどう膜炎, 7 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 熊谷直樹: "Current Encyclopedia of Ophthalmoolgy" ぶどう膜 交感性眼炎, 5 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "Current Encyclopedia of Ophthalmoolgy" ぶどう膜 ライム病, 3 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "Current Encyclopedia of Ophthalmoolgy" ぶどう膜 ぶどう膜炎の分類, 4 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "Current Encyclopedia of Ophthalmoolgy" 全身疾患と眼 Behcet病, 12 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "Current Encyclopedia of Ophthalmology" ぶどう膜 Brchet病, 10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takano M.: "Advances in Ocular Immunology" Interleukins enhanced neural regeneration of axotomized retinal ganglion cells in adult mammals, 2 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishio M.: "Advances in Ocular Immunology" Effect of genetically engineered vaccine on Pscudomonas aeruginosa infection in mice, 4 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大野重昭: "眼科クルズス(専門医研修のために)" Behcet病, 5 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shindo Y., Inoko H., Yamamoto T., Ohno S.: "HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-" British Journal of Ophthalmology. 78. 223-226 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shindo Y., Ohno S., Yamamoto T., Nakamura S., Inoko H.: "Complete association of the HLA-DRB1^*04 and-DQB1^*04" Hum Immunol. 39. 169-176 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Goto K., Saeki K., Kurita M., Iijima Y., Miyake A., Ohno S.: "HTLV-I seroprevalence in patients with undefined uveitis in" Japanese Journal of Ophthalmology. 38. 175-177 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishihara M., Ohno S., Ishida T., Ando H., Naruse T., Nose Y.: "Molecular genetic studies of HLA class II alleles in sarcoidosis" Tissue Antigens. 43. 238-241 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Uchio E., Kijima M., Tanaka S., Ohno S.: "Suppression of experimental uveitis with monoclonal antibodies" Invest Ophthalmol Vis Sci. 35 : 5. 2626-2631 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Igarashi T., Ishigatsubo Y., Ohno S., Ueda A., Okubo T., Tanaka: "Central nervous system toxicity related to FK506 in patients" Ann Rheum Dis*@. 53 : 5. 350-351 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Isogai E., Isogai H., Kawabata H., Masuzawa T., Yanagihara: "Lyme disease Spirochetes in a wild fox (Vulpes vulpes schrencki)" J Wildl Dis. 30 : 3. 439-444 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Uchio E., Hatano H., Mitsui K., Sugita M., Okada K., Goto K.: "A retrospective study of herpes simplex keratitis over the last 30" J.J.Ophthalmol.38 :. 196-201 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takano M., Horie H., Takenaka T., Ohno S.: "Interleukins enhanced neural regeneration of axotomized retinal" Advansed in Ocular Immunology. 25-26 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nisihio M., Nakamura S., Ishii N., Tanaka S., Okuda K., Ohno S.: "Effect of genetically engineered vaccine on Pseudomonas" Advances in Ocular Immunology. 285-288 (1994)

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    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishioka M., Ohno S.Nakamura S., Isobe K., Watanabe N.: "FK 506 Treatment of Noninfectious Uveitis" American Journal of Ophthalmoloty. 118 : 6. 723-729 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizuki N., Inoko H., Ishihara M., Ando H., Nakamura S.: "A complete type patient with Behcet's disease associated with" Acta Ophthalmol. 72 :. 757-758 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S,Shindo Y: "Classification of uveitis" Current Encyclopedia of Ophthalmology. 55-58 (1994)

    • Description
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      1994 Final Research Report Summary
  • [Publications] Shindo Y,Ohno S: "Eye involvements and therapy of autoimmune diseases" Rinsyoui. 20 : 2. 69-71 (1994)

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      1994 Final Research Report Summary
  • [Publications] Takakura Y,Takano M,Yonemoto J,Ohno S: "Retinal detachment associated with atopic dermatitis" Ganka Rinsyou Ihou. 88 : 4. 90-91 (1994)

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      1994 Final Research Report Summary
  • [Publications] Ishihara M,Ohno S,Ishida K,Kagiya M,Ando H,Inoko H: "Analysis of susceptibility genes in Sarcoidosis" Nihon Gankagakkai Zasshi. 98 : 1. 80-85 (1994)

    • Description
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      1994 Final Research Report Summary
  • [Publications] Matsumoto S,Ohno S: "Ocular involvement of pollen allergy" MEDICO. 25 : 1. 9-11 (1994)

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      1994 Final Research Report Summary
  • [Publications] Nakagawa H,Ohno S,Isobe Y,Aoki K,et.al.: "Rapid diagnosis of adenovirus conjunctivitis with the method of ELISA" Nihon-no-Ganka. 65 : 3. 13-18 (1994)

    • Description
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      1994 Final Research Report Summary
  • [Publications] Ishioka M,Nakamura S,Mori K,Matsumoto M,Ohno S: "A case of Behcet's disease with convulsion during FK 506 therapy" Ganka. 36 : 6. 695-697 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Aoki K,Ohno S: "The results of surveillance in infectious ocular diseases" Nihon-no-Ganka. 65 : 4. 345-345 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ishihara M,Ohno S,Ishida K,Kagiya M: "Analysis of susceptibility genes in sarcoidosis" Nihon Gankagakkai Zasshi. 98. 80-85 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mori H,Yonemoto J,Takano M,Ohno S.: "A clinical survey of retinal pigment epithliopathy" Rinsho Ganka. 48 : 5. 938-939 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S.: "A guide for systemic steroid therapy" Nihon-no-Ganka. 65 : 7. 779-779 (1994)

    • Description
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    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakamura S,Ohno S: "Uveitis associated with ankylosing spondylitis, HLA-B27, and Reiter's" Current Encyclopedia of Ophthalmology. 4 :. 169-175 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kumagai N,Ohno S: "Sympathetic ohthalmia" Current Encyclopedia of Ophthalmology. 4 :. 261-265 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S: "Systemic disease and eye-Behcet's disease" Current Encyclopedia of Ophthalmology. 4 :. 243-244 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kumagai N,Ohno S.: "Ocular allergy" Saishin Igaku. 49. 131-143 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shindo Y,Ohno S: "Lyme disease" Rinsyou Ganka. 48 : 2. 123-129 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mizuki N,Ohno S: "Immunogenetic studies on Behcet's disease" Igaku-no-ayumi. 168 : 7. 723-725 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukami R,Ohba S,Ishida K,Nakamura S,et.al.: "Serum adenosine deaminase and angiotensin ci=onverting enzyme" Nihon Gankagakkai Zasshi. 98 : 3. 287-292 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugiura N,Uchio E,Matsumoto T,et.al.: "Clinical profile and classification of Herpes zoster ohthalmicus" Rinsyou Ganka. 48 : 3. 346-347 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumoto T,Hatano H,Ohno S,et.al.: "Topical ciclosporin for sclerocorneal ulcer associated with Wegener's" Rinsyou Ganka. 48 : 3. 350-351 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S,Shindo Y: "Systemic disease and eye-Behcet's disease" Current Encyclopedia of Ophthalmology. 4 :. 199-208 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S,Shindo Y: "Lyme disease" Current Encyclopedia of Ophthalmology. 111-113 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshikawa M,Nishio M,Nakamura S,et.al.: "Comparison of systemic FK 506 and cyclosporin for Behcet's disease" Rinsyou Ganka. 48 : 6. 1196-1197 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki K,Aoki K,Isobe K,Numasaki K,et.al.: "Involvement of Chlamydia pneumoniae in endogenous uveitis" Rinsho Ganka. 48 : 6. 1208-1209 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hanajiri M,Matsumot T,Hatano H,Ohno S: "Herpes Zoster ohthalmicus without skin eruptions" Rinshou Ganka. 48 : 4. 658-660 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugita M,Ohno S.: "Clinical features and therapies of uveitis" Nihon-no-Ganka. 65 : 8. 919-921 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakao K,Ohba N,Inomata H,et.al.: "A multicenter clinico-epidemiological study of HTLV-1 associated uveitis" Nihon Gankagakkai Zasshi. 98 : 9. 858-865 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S: "Behcet's desease" Lecture of Ohthalmology. 358-362 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohno S,Kou C: "Anthropological and molecular biological studies on uveitis" Nichu Igaku. 9 : 1. 5-8 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yokota K.,Hayashi S.,Kotake S.,Ohno S.etal.: "Antibody response to oral Streptococci in Behcet's disease." Microbiol.Immunol.36. 815-822 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mizuki N.,Inoko H.,Kashiwase K.,Ohno S.etal.: "Behcet's disease associated with one of the HLA-B51 subantigens, HLA-B^*5101." Am J Ophthalmol. 116. 406-409 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamakawa Y.,Sugita Y.Takahashi Y.,Ohno S.etal.: "Gene expression of tumor necrosis factor-alpha(TNF-alpha) and heat-shock protein(HSP) 70 in patients with Behcet's disease." Arch Dermatol Res.285. 505-508 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ishii N.,Isogai E.Yamakawa Y.,Ohno S.etal..: "Demonstration of antigen-specific immune response against Streptococcus sanguis." J Dermatol Sci.5. 182-189 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭: "HLAとぶどう膜炎" 日本の眼科(臨時増刊). 63. 15-17 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 木島正哉、大野重昭: "副賢皮質ステロイド剤の基礎と臨床" 眼科. 35. 755-763 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉田美由紀、中村聡,大野重昭、他: "横浜市大眼科におけるぶどう膜炎の疫学的研究" 臨床眼科. 47. 1249-1252 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 沖坂重邦、大野重昭: "謬原病と類縁疾患(3)" Medical Practice. 10. 1619-1627 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 松本覚、大野重昭: "ベーチェット病の疫学" 日本医事新報. 3622. 134-135 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 新藤裕美子、大野重昭: "Behcet病と原田病の眼病変" Practitioners. 2. 993-996 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山川有子、杉田泰之、高橋泰英、大野重昭、他: "ベーチェット病患者におけるTNF-alpha産生能について" 横浜医学. 44. 215-221 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭、水木信久: "Behcet病の分子遺伝学" 医学のあゆみ. 164. 52-56 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 新藤裕美子、大野重昭: "ぶどう膜炎の診断と治療" 総合臨床. 42. 2569-2570 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 新藤裕美子、大野重昭: "自己免疫疾患の眼病変とその治療" 臨床医. 20. 69-71 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 水木信久、大野重昭: "Behcet病の免疫遺伝学的解析" 医学のあゆみ. 168. 723-725 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishio M.,Isobe Y.,Hatano H.,Ohno S.etal.: "The genetic effect of engineered vaccine on Pseudomomonas aeruginosa infection in mice." Immunogenetics. 38. 280-282 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭: "成人T細胞白血病ウイルスと眼疾患" 日本眼科学会誌. 97. 663-664 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 石原麻美、大野重昭、石田敬子、鍵谷雅彦、他: "サルコイドーシスにおける疾患感受性因子の検討" 日本眼科学会雑誌. 98. 80-85 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mizuki N.,Ohno S.: "Rrcent Advances in Uveitis" Kugler Publications, 6 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] nakamura S.,Sugita M.Tanaka S.,Ohno S.,: "Recent Advances in Uveitis" Kugler Publications, 4 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugita M.,Enomoto Y.Ohno S.etal.: "Rrcent Advances in Uveitis" Kugler Publications, 3 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Watanabe N.,Ishioka M.Ohno S.etal.: "Recent Advances in Uveitis" Kugler Publications, 4 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] MIzuki N.,Nakamura S.Ando H.,Ohno S.etal.: "Behcet's disease" Elsevier Science Publishers BV, 4 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Isogai E.,Yokota K.Fujii N.,Ohno.etal.: "Behcet's disease" Elsevier Science Publishers BV, 10 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 新藤裕美子、大野重昭: "眼病変を読む -全身疾患と眼-" 診断と治療社, 4 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭: "今日の治療指針" 医学書院, 1 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭、新藤裕美子: "眼科学大系(4)" 中山書店, 4 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭、新藤裕美子: "眼科学大系(4)" 中山書店, 8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大野重昭: "マスト細胞とアレルギー" 医科学出版社, 4 (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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