| Project/Area Number |
05671755
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
SUEMUNE Hiroshi KYUSHU UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,ASSISTANT PROFESSOR, 薬学部, 助手 (20095897)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Asymmetric synthesis / Asymmetric reaction / Configuration / Chiral cyclic diol / Chiral enol ether / Chelation |
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| Research Abstract |
Based on our previous study for preparation of enantiomerically pure cycloalkane-1,2-diols by using enzymatic procedure, several asymmetric reactions have been developed in this research project.
1)A new method for asymmetric construction of a quatemary carbon and its application to the synthesis of spiro-cyclic compound have been developed by using cycloalkane-1,2-diols as a chiral auxiliary.
2)New types of asymmetric reactions have been developed by using "chiral enol ether" as a key intermediate : Two kinds of asymmetric Michael reaciton ; Asymmetric oxidation of beta-keto esters ; Chiral induction to meso-cyclic 1,2-diol.
3)Asymmetric spiro-cyclization has been developed by using chiral cycloalkane-1,2-diol as a chiral sorce.
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