| Project/Area Number |
05671769
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy & Life Science |
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Principal Investigator |
TAKEYA Koichi Tokyo University of Pharmacy & Life Science, Pharm., Ass. Prof., 薬学部, 助教授 (20120149)
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| Co-Investigator(Kenkyū-buntansha) |
HITOTSUYANAGI Yukio Tokyo University of Pharmacy & Life Science, Pharm., Lecturer, 薬学部, 講師 (80218726)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Antitumor substance / Cytotoxic substance / Eurycoma / Abuta / Cissampelos / Maytenus / Tropone / Quassinoid / 生理活性物質 / Ailanthus / Msayenus / トロポロン / トリテルペン / 細胞毒性物質 / Abuta concolor / Cissampelos pareira / トロポロイソキノリンアルカロイド / アザフルオランセンアルカロイド / Eurycoma longifolia / quassinoid / triterpene |
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| Research Abstract |
Many plants collected in the neotropical region, mainly in South America and Indonesia, were assayd for their antitumor and cytotoxic activities by using Sarcoma 180 ascites in mice and V-79, P388 and KB cells, respectively. Those plants shown to be biologicaly active by these screening tests were further investigated to identify their active principles. The isolation, structural elucidation and biological activities of active principles from those plants were studied. As the biological active compounds, quassinoids, squalene-type triterpene ethers and tirucallane-type triterpenes were isolated from Eurycoma longifolia (Simaroubaceae), aromatized triterpenes and their dimers from Maytenus plants (Celastraceae), and tropoloisoquinoline and azafluoranthene alkaloids from Cissampelos pareira and Abuta concolor (Menispermaceae).
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