| Project/Area Number |
05671770
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo College of Pharmacy |
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Principal Investigator |
HANZAWA Yuji Tokyo College of Pharmacy, School of Pharmaceutical Science, Associate Professor, 薬学部, 助教授 (10096688)
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| Project Period (FY) |
1993 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Early transition metal / Zirconocene-butene complex / Ring contraction / Steroidal side chains / Diastereoselective synthesis / Catalyst / Oxetanocin / Vinylcyclopropane / ジルコノセン-ブテン錯体 / η^3-πアリルジルコノセン錯体 / ステロイド / ジルコノセン等価体 / アリルジルコニウム / 環縮小反応 / ビニルモルホリン / ピロリジン / ピロリチジン / 錯体 / ジルコノセン / ニオビウム / アリルラジカル / オキセタノシン / カップリング |
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| Research Abstract |
In our ongoing research project on organic syntheses using early transtition metals, zirconium, vanadium, niobium etc., we have exploited enormous possibilities of low valent zirconium complex, zirconocene-butene complex, for organic synthesis. During the past term of project we established an efficient method for the preparation of optically pure carbocycles by treating vinyl sugar derivatives with zirconocene-butene complex and an application to the synthesis of bioactive molecules. We also established the construction of steroidal side chain based on the reaction of zirconocene with vinylcyclopropane, and we have also studied a short-step construction of steroidal skeleton based on the reaction of zirconocene and alkoxymethylated stirene derivatives.
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