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ROLE OF ANXIETY/FEAR IN PSYCHOLOGICAL STRESS-INDUCED ANTINOCICEPTION AND A NOVEL METHOD FOR SCREEING ANXILYTICS USING THE STRESS

Research Project

Project/Area Number 05671831
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNagasaki University

Principal Investigator

TAKAHASHI Masakatsu  Faculty of Pharmaceutical Sciences, Nagasaki University Associate Professor, 薬学部, 助教授 (90112383)

Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsPsychological Stress / Psychic dependence / Elevated Plus-Maze / Anxiolytic Drugs / Morphine / Emotional Factors / Antinociceptive Tolerance / Stress-Induced Antinociception / 学習・記憶 / ストレス鎮痛 / オピオイド受容体
Research Abstract

Studies have been carried out to clarify the role of emotional factors e.g., anxiety and fear underling the production of antinociception (stress-induced analgesia, SIA) and the blockade of the development of tolerance to morphine antinociception by exposure to psychological (PSY) stress using the communication box. 1. Both PSY-SIA and the suppression of the development of morphine tolerance were completely extinguished by diazepam (DZP), suggesting an essential role of emotional factors in the underlying mechanisms. Methysergide, buspirone, ritanserin and Y-25,130 dose-dependently suppressed both the production of PSY-SIA and the blockade of tolerance development by PSY-stress, while neither (<plus-minus>) pindolol nor imipramine was inffective. Thus, it is suggested that 5-HT receptor (5-HT_<1A>,5-HT_2 and 5-HT_3 but not5-HT_<1B>) -mediated mechanisms participate in the appearance of various responses to PSY stress, and furthermore, to observe the extinguishable effect of drugs on th … More e stress-induced responses, e.g., analgesia and suppression of the development of morphine tolerance, would be valid for a new method for screening anxiolytic drugs in mice. 2. The development of antinociceptive tolerance to morphine was significantly delayd in the presence of inflammatory pain induced by formalin. While indomethacin and aspirin had no effects on the delay of the development of morphine tolerance, diazepam completely abolished the delay. These results suggest that pain associated anxiety participates in the delay of the development of morphine tolerance. 3. In an elevated plus maze method, PSY-stress produced the anxiogenic effect. 4. Exposure to PSY-stress induced a significant place aversion in the conditioned place preference method, while the stress potentiated the reinforcing effect of morphine. 5. Pre-training PSY-stress in the one trial passive avoidance learning task resulted in enhanced test latency. Naloxone did not affect the facilitatory effects, suggesting different mechanisms are involved in stress-induced memory modification and the production of SIA. Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Shogo Tokuyama: "Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice" Japan.J.Pharmacol.61. 237-242 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.F.M.M.Rahman: "Development of tolerance to morphine antinociception in the mice treated with nociceptive stimulants" Japan.J.Pharmacol.63. 59-64 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 金戸 洋: "疼痛状態下でのモルヒネ耐性の形成" 精神薬療基金研究年報. 24. 88-93 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 金戸 洋: "麻薬性鎮痛薬に対する耐性・依存形成の抑制に関する研究-疼痛モデルマウスにおける研究-" 薬物依存の発生機序と臨床及び治療に関する研究-平成4年度研究成果報告書-厚生省「精神・神経疾患研究委託費」. 27-34 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.F.M.M.Rahman: "Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice" Japan.J.Pharmacol.65. 313-317 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.F.M.M.Rahman: "Morphine dependence with or without tolerance in formalin-treated mice:further evidence for the dissociation" Japan.J.Pharmacol.66. 277-280 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 金戸 洋: "情動ストレス反応の機構解明とこれに基づく抗不安薬の検定法の開発" 精神薬療基金研究年報. 25. 77-83 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Luis Jodar: "Trends in physiological role of opioids in psychoneuroendocrine-immune network" Japan.J.Psychopharmacol.14. 195-214 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Luis Jodar: "Effect of footshock-.psychological-and forced swimming-stress on the learning and memory processes:Involvement of opioidergic pathways" Japan.J.Pharmacol.24. 88-93 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高橋 正克: "心理的ストレス反応を指標とした抗不安薬の評価法" 日本神経精神薬理学雑誌. 15(受理). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tokuyama, S.et al.: "Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice." Japan. J.Pharmacol.61(3). 237-242 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.M.F.F.Rahman et al.: "Development of tolerance morphine antinociception in the mice treated with nociceptive stimulants." Japan. J.Pharmacol.63(1). 59-64 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kaneto, H.et al.: "Development of tolerance to morphine in mice with experimental chronic pain." Ann.Rep.Pharmacopsychiat. Res.Found.24. 88-93 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.M.F.F.Rahman et al.: "Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice." Japan. J.Pharmacol.65(4). 313-317 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.M.F.F.Rahman et al.: "Morphine dependence with or without tolerance in formalin-treated mice : further evidence for the dissociation" Japan. J.Pharmacol.65(4). 313-317 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kaneto, H.et al.: "Studies on the mechanism underlying the response to psychological stress and the development of a novel method for screening asxiolytics in mice.19GC06 : Ann.Rep.Pharmacopsychiat. Res. Found." 25. 77-83 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jodar, L.et al.: "Trends in physiological role of opioids in psychoneuroendocrine-immune network" Japan. J.Psycho-pharmacol.14 (4). 313-317 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jodar, L.et al.: "Effect of footshock-, psychological- and forced swimming-stress on the learning an memory processes : involvement of opioidergic pathways." Japan J.Pharmacol.67(2). 143-147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shogo Tokuyama: "Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice." Japan.J.Pharmacol.61. 237-242 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] A.F.M.M.Rahman: "Development of tolerance to morphine antinociception in the mice treated with nociceptive stimulants" Japan.J.Pharmacol.63. 59-64 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 金戸 洋: "疼痛状態下でのモルヒネ耐性の形成" 精神薬療基金研究年報. 24. 88-93 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 金戸 洋: "麻薬性鎮痛薬に対する耐性・依存形成の抑制に関する研究-疼痛モデルマウスにおける研究-" 薬物依存の発生機序と臨床及び治療に関する研究-平成4年度研究成果報告書-厚生省「精神・神経疾患研究委託費」. 27-34 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] A.F.M.M.Rahman: "Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice." Japan.J.Pharmacol.65. 313-317 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] A.F.M.M.Rahman: "Morphine dependence with or without tolerance in formalin-treated mice:further evidence for the dissociation." Japan.J.Pharmacol.66. 277-280 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 金戸 洋: "情動ストレス反応の機構解明とこれに基づく抗不安薬の検定法の開発21GC07:精神薬療基金研究年報" 25. 77-83 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Luis Jodar: "Trends in physiological role of poioids in psychoeuroendocrine-immune network" Japan.J.Psychopharmacol.14. 195-214 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Luis Jodar: "Effect of footshock-, psychological-and forced swimming-stress on the learning and memory processes: Involvement of poioidergic phthways." Japan.J.Pharmacol.67(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shogo Tokuyama: "Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mine." Japan.J.Pharmacol.61. 237-242 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.F.M.M.Rahman: "Development of tolerance to morphine antinociception in the mice treated with nociceptive stimulants" Japan.J.Pharmacol.63. 59-64 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 金戸 洋: "疼痛状態下でのモルヒネ耐性の形成" 精神薬療基金研究年報. 24. 88-93 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 金戸 洋: "麻薬性鎮痛薬に対する耐性・依存形成の抑制に関する研究-疼痛モデルマウスにおける研究-" 薬物依存の発生機序と臨床及び治療に関する研究-平成4年度研究成果報告書-厚生省「精神・神経疾患研究委託費」. 27-34 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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