| Project/Area Number |
05671833
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Gifu Pharmaceutical University |
|---|
Principal Investigator |
NAGAI Hiroichi Department of Pharmacology, Gifu Pharmaceutical University, Professor, 薬学部, 教授 (90082974)
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | Allergic tissue inflammation / Allergic airway inflammation / Arthritis / Nephritis / MRL / lpr Yaa / Cyclophosphamide / type II collagen関節炎 / 自己免疫疾患モデル / lpr Yaa / 腎炎 / メゾポルフィリン / アレルギー / サイトカイン / 自己免疫疾患 / インターロイキン |
|---|
| Research Abstract |
The present study was carried out to investigate the remedy for allergic tissue inflammation including ariway inflammation, dermatitis and nephritis. Regarding a mimic model for above diseases, there is scarecely oppotunity to obtain an appropriate model for pharmacological study. In the first part of the present study, we have tried to develop a new pharmacological model to an allergic tissue inflammatory disease. The first experiment was focused on the airway inflammation resultd in the airway hyperreactivity. We have obtained two appropriate models for airway hyperreactivity in guinea pigs and mice. These models show similar clinical symptoms to human disease. Thromboxane A2 and interleukin 5 play an important role for the onset and development of airway obstraction. Secondary, we have developed new pharmacological models for atopic dermatitis in mice. We used monoclonal IgE antibody for passively sensitization. Topical application of antigen leads atopic dermatitis in the skin lesion. We find the role of tumour necrosis factor for onset of the dermatitis. The last study was conducted to investigate autoimmune tissue inflammation, arthritis and nephritis. We are now evaluating the pharmacologica value of our new models, MRL/lpr Yaa mice and SEB-induced arthritis. The results are not good enough to report. We will complete the study in the near feature.
|
