| Project/Area Number |
05680463
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
環境影響評価(含放射線生物学)
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
HIGASHI Terumasa Osaka University, Medical School, Associate Professor, 医学部, 助教授 (80116087)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAGAWA Setsuko Osaka University, Medical School, Assistant, 医学部, 助手 (60187060)
KAWAGUCHI Naomasa Osaka University, Medical School, Assistant, 医学部, 助手 (70224748)
ONISHI Shunzo Osaka University, Medical School, Professor, 医学部, 教授 (00028367)
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Static magnetic field / Magnetic anisotropy / Erythrocyte / Blood platelet / Glutaraldehyde / Biological membrane / Hemoglobin / Magnetic orientation / マイクロツブルス |
|---|
| Research Abstract |
In a homogeneous static magnetic field, intact erythrocytes oriented their disk surface parallel to the direction of magnetic field. This orientation was produced by diamagnetic anisotropies in the erythrocyte membrane components, the lipid bilayr and the transmembrane proteins, and was not due to the magnetism of hemoglobin molecules. Intact platelets also took the same orientation as intact erythrocytes, but in this case, not only the magnetic properties of membrane constituents but also the magnetic anisotropy of cytoskeletal protein, microtubules were responsible for the orientation. By contrast, erythrocytes fixed by glutaraldehyde showed an orientation in which their disk surface was vertical to the direction of magnetic field. The paramagnetism of methemoglobin molecules is thought to contribute significantly to this orientation.
|
