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Chemical Study on Natural Products Enahncing Neurite Outgrowth

Research Project

Project/Area Number 05680516
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Bioorganic chemistry
Research InstitutionTokushima Bunri University

Principal Investigator

FUKUYAMA Yoshiyasu  Tokushima Bunri University, Faculty of Phamaceutical Sciencces, Associate Professor, 薬学部, 助教授 (70208990)

Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsNeurotrophic substance / Neurite outgrowth / 5-Lipoxygenase inhibitor / Sesquiterpene / C6-C3 compound / 1,4-Benzoquinone / Lignan / Xanthone
Research Abstract

Search for neurotrophic substances in natural products resulted in the discovery of several new following compounds ; eudesobovatol A,eudeshonokiol B,clovanemagnolol, and caryolanemagnolol from Magnolia obovata, mastiogophorenes A and B from Mastigophora diclados, americanol A and isoamericanol A from Phytolacca americana, garciniaxanthone A from Garcinia subelliptica, illicinone E and tricycloillicinone from Illicium tashiroi.These compounds enhanced not only neurtite outgrowth but also ChAT activity in primary cultured neuron of fetal rat cerebral hemispherer at 10^<-5> - 10^<-7> M.Several new 1,4-benzoquinone derivatives named belamcandaquione, and ardisiaquinones A,D,E,and F were found as potent 5-lipoxygenase inhibitors from Belamcanda chinensis and Ardisia sieboldii, respectively.All of them were practically synthesized from the common intermediate, which was coupled via an acetylene unit.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 福山 愛保: "神経の突起伸張を促進する天然物質" 科学と工業. 66. 197-207 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiyasu Fukuyama: "Isodunnianin, A New Sesquiterpene Enhancing Neurite Outgrowth in Primary Culture of Fetal Rat Cebrebral Hemisphere from Illicium tashiroi" Planta Medica. 59. 181-182 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiyasu Fukuyama: "Structure of Magnolianin,A Novel Triilignan Possessing 5-Lipoxygenase Inhibitory Activity" Tetrahedron Letters. 34. 1051-1054 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiyasu Fukuyama: "Belamcandaquinone A and B,Novel Dimeric 1,4-Benzoquinone Derivatives Possessing Cyclooxygenase Inhibitory Activity" Tetrahedron Letters. 34. 7633-7636 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiyasu Fukuyama: "New Chlorin-containing Prenylated C6-C3 Compounds Increasing Cholin Acetyltransferase Activity in Culture of the Postnatal Rat Septal Neurons from Illicium tashiroi" Chem. Pharm. Bull.42. 2199-2201 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiyasu Fukuyama: "Total Synthesis of Ardisiaquinone A,a Potent 5-Lipoxygenase Inhibitor,Isolated from Ardisia sieboldii and Degree of 5-Lipoxygenase Inhibitory Activitv of its Derivatives" Chem. Pharm. Bull.42. 2211-2213 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, Y.Otoshi, K.Miyoshi, K.Nakamura, M.Kodama, M.Nagasawa, T.Hasegawa, H.Okazaki, and M.Sugawara: "Neurotrophic Sesquiterpene-neolignans from Magnolia obovata : Structures and Neurotrophic Activity" Tetrahedron. 48. 377-392 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama: "Neurotrophic Natural Products" Kagaku to Kougyou. 67. 197-207 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, Y.Kiriyama, J.Okino, and M.Kodama: "Naturally Occurring 5-Lipoxygenase Inhibitor.II Structures and Syntheses of Ardisianones A and B,and Maesanin, Alkenyl-1,4-benzoquinones from the Phizome of Ardisia japonica" Chem.Pharm.Bull.41. 561-565 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, Y.Otoshi, K.Miyoshi, N.Hasegawa, and M.Kodama: "Structure of Magnolianin, A Novel Triilignan Possessing 5-Lioxygenase Inhibitory Activity" Tetrahedron Lett.34. 1051-1054 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, N.Shida, and M.Kodama: "Isodunnianin : A New Sesquiterpene Enhancing Neurite Outgrowth in Primary Culture of Fetal Rat Hemisphere from Illicium tashiroi" Plant Med.59. 181-182 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, Y.Kiriyama, J.Okino and M.Kodama: "Belamcandaquinones A and B,Novel Dimeric 1,4-Benzoquinone Derivatives Possessing Cyclooxygenase Inhibitory Activity" Tetrahedron Lett.34. 7637-7640 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Minami, M.Kinoshita, Y.Fukuyama, and M.Kodama: "Antioxidant Xanthones from Garcinia subelliptica" Phytochemistry. 36. 501-506 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, N.Shoda, Y.Hata, and M.Kodama: "Prenylated C6-C3 Compounds from Illicium tashiroi" Phytochemistry. 36. 1497-1503 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, K.Okamoto, Y.Kubo, N.Shida, and M.Kodama: "New Chlorine-containing Prenylated C6-C3 Compounds Increasing Choline Acetyltransferase (ChAT) Activity in culture of Postnatal Rat Septal Neurons from Illicium tashiroi" Chem.Pharm.Bull.42. 2199-23201 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, Y.Kiriyama, M.Kodama, H.Iwaki, S.Hosozawa, S.Aki, and K.Matusi: "Total Synthesis of Ardisiaquinone A,a Potent 5-Lipoxygenase Inhibitor, Isolated from Ardisia sieboldii, and Degree of 5-Lipxoygenase Inhibitory Activity of Its Derivatives" Chem.Pharm.Bull.42. 2211-2213 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama, N.Shida, and M.Kodama: "Tashironin, a Plausible Biosynthetic Precursor of Anisatin-type Sesquiterpenes" Tetrahedron Lett.36. 583-2586 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Fukuyama: "A Cardenolide from Anodendron affine" Phytochemistry. 35. 1077-1080 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Fukuyama: "Antioxidant Xanthones from Garcinia subelliptica" Phytochemistry. 36. 501-506 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Fukuyama: "Eight Prenylated C6-C3 Compounds from Illicium tashiroi" Phytochemistry. 36. 1497-1503 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Fukuyama: "Prenylated C6-C3 Compounds Related to Ellicinone E from Illicium tashiroi" Phytochemistry. 37. 1497-1503 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Fukuyama: "New Chlorine-Containing Prenylated C6-C3 Compounds Increasing Choline Acetyltransferase(ChAT)Activity in Culture of the Postnatal Rat Septal Neurons from Illicium tashiroi" Chem.Pharm.Bull.42. 2199-2201 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Fukuyama: "Toatl Synthesis of Ardisiaquinone A,a Potent 5-Lipoxygenase Inhibitor,Isolated from Ardisia sieboldii and Degree of 5-Lipoxygenase Inhibitory Activity of Its Derivatives" Chem.Pharm.Bull.42. 2211-2213 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 福山,愛保: "神経の突起伸展を促進する長然物質" 化学と工業. 67. 197-207 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Fukuyama: "Isoduniannin,A New Sesquiterpene Enhancing Neurite Outgrowth in Primary Culture of Felal Rat Cerebral Hemisphere from Illicium tashiroi" Planta Medica. 59. 181-182 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Fukuyama: "Naturally Occurring 5-Lipoxygenase Inhibitor.II Structures and Syntheses of Ardisiaquinones A and B.and Maesanin.Alkenyl-1,4-benzoquinones from the Rhizome of Ardisia japonica" Chem.Pharm.Bull.41. 561-565 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Fukuyama: "Structure of Magnolianin,A Novel Trilignan Possessing 5-Lipoxygenase Inhibitory Activity" Tetrahedron Letters. 34. 1051-1054 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Fukuyama: "Belamcandaquinones A and B,Novel Dimcric 1,4-Benzoquinone Derivatives Possessing Cyclooxygenase Inhibitory Activity" Tetrahedron Letters. 34. 7633-7636 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Fukuyama: "Concise Synthesis of Belamcandaquinones A and B by Palladium(0)Catalyzed Cross-Coupling Reaction of Bromoquinone with Arylboromic Acids" Tetrahedron Letters. 34. 7637-7640 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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