Cathepsin E- hydrolytic specificity for biologically active peptides and gene expression during development
| Project/Area Number |
05680638
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KAGEYAMA Takashi Kyoto Univ., Primate Res.Inst., Associate Professor, 霊長類研究所, 助教授 (20027501)
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| Co-Investigator(Kenkyū-buntansha) |
ASAOKA Kazuo Kyoto Univ., Primate Res.Inst., Instructor, 霊長類研究所, 助手 (10089138)
YONEZAWA Satoshi Aichi Prefectural Colony, Leader, 発達障害研究所, 所長 (90001867)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | cathepsin E / procathepsin E / substance P / FGF / tachykinin / development / カテプソンE |
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| Research Abstract |
1. Procathepsin E was detected at high levels in various fetal tissues.
2. Procathepsin E has unique structural and enzymatic features.
3. Cathepsin E hydrolyzed various biologically active peptides, such as substance P,neurokinin A,and FGF fragments, at around pH 5.
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Report
(3 results)
Research Products
(6 results)
