| Project/Area Number |
05680653
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
OYANAGI Kiyomitsu Niigata University, Brain Research Institute, Associate Professor, 脳研究所, 助教授 (00134958)
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Fusahiro Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (20018592)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Amyotrophic lateral sclerosis / Degeneration / Spinal cord / Anterior horn / Intermediate zone / Intermediolateral nucleus / Transneuronal degeneration / Guam ALS / 運動ニューロン / 肢切断 |
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| Research Abstract |
Was the degeneration in the extra-motor neuron system of the amyotrophic lateral sclerosis (ALS), induced secondarily to the loss of motor neurons? In relation to this, loss of neurons was found not only in the anterior horn but also in the intermediate zone of the cervical spinal cord in a 56-year-old man who had suffered accidental amputation of the right upper arm 38 years prior to death. This finding indicates that the loss of neurons in the intermediate zone of the spinal cord in ALS patients is sequentially induced at least partly by loss of the anterior horn cells.
The neurons in the intermediolateral nucleus at the thoracic segment of the ALS patients, were involved primarily in the disease process without the formation of Bunina bodies, and were more severely decreased in the respirator-supported patients than non-respirator-supported patients.
We elucidated that the mechanism of neuronal degeneration of Guam ALS is basically different from that of the parkinsonism-dementia complex of Guam, and that Guam ALS occurs initially as classic ALS.
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