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Mechanism of epileptogenesis of the Mongolian gerbil, a gnetical animal model of epilepsy.

Research Project

Project/Area Number 05680748
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

SETO Akiko  Department of Morphology, Institute for Developmental Research Aichi Prefectural Colony, Senior Researcher, 形態学部, 主任研究員 (50142170)

Co-Investigator(Kenkyū-buntansha) ITO Muneyuki  Department of Physiology, Institute for Developmental Research Aichi Prefectural, 生理学部, 部長 (80100155)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsGerbil / Epileptogenesis / Vestibular cortex / P70
Research Abstract

The Mongolian gerbil (Meriones unguiculatus), a genetical animal model of epilepsy, shows the epileptic motor manifestations elicited by several kinds of stimulation. We found that the rhythmical movement of the pinnae occurring after posture change, a strong inducer of the seizure, was the first detectable sign of the stimulus-induced behaviors which would develop into adult-type seizure manifestations. Electrophysiological study showed that the movement of the pinnae was induced when an area of the sensorimotor cortex was stimulated electrically. This area was overlapped spatially with the vestibular cortex determined by electrical stimulation of the vestibular organ. Neurotracing analysis showed that the thalamic area projecting to the cortical area for the movement of the pinnae seemed to correspond to that thought to project to the vestibular cortex in other animal species. Since vestibular stimulation is a presumptive extrinsic factor involved in the posture change, these results and other electrophysiological and morphological observations seem to support our hypothesis that the vestibular stimulation induces progressively increasing number of afterdischarge in a cortical area which is responsible to the formation of epileptic manifestations starting from the movement of the pinnae. In the neurons of the gerbil, there was a protein like P70, a70 kDa protein considered to be involved in the epiletogenesis of cobalt-treated rat. This protein may be a genetically determined factor to lower the threshold of the neurons of this animal species.

Report

(3 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Seto-Ohshima,A.,Aoki,E.,Omori,A.,Mizutani,A.,Murashima,M.&Heizmann,C.W.: "Parvalbumin immunoreactivity and cytochrome oxidase activity in the brain of the gerbil." Acta Histochem.Cytochem.27. 309-321 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ito,M.: "Barrel field of the prenatally X-irradiated rat somatosensory cortex:A histochemical and electrophysiological study." J.Comp.Neurol.352. 248-262 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seo-Hiraiwa,M.L.,Seto-Ohshima,A.& Kato,K.: "The surface evoked potential and parvalbumin immunoreactivity in the somatosensory cortex of the developing rat." Develop.Psychobiol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seto-Ohshima,A.: "Review:Calcium-binding proteins in the central nervous system." Acta Histochem.Cytochem.27. 93-106 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seto-Ohshima, A., Aoki, E., Omori, A., Mizutani, A.Murashima, M.and Heizmann, C.W.: "Parvalbumin immunoreactivity and cytochrome oxidase activity in the brain of the gerbil." Acta Histochem.Cytochem. 27. 309-321 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ito, M.: "Barrel field of the prenatally X-irradiated rat somatosensory cortex : A histochemical and electorphysiolgical study." J.Comp.Neurol.352. 248-262 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seo-Hiraiwa, M.L., Seto-Ohshima, A.and Kato, K.: "The surface evoked potential and parvalbumin-immunoreactivity in the somatosensory cortex of the developing rat." Develop. Psychobiol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seto-Ohshima, A.: "Review : Calcium-binding proteins in the central nervous system." Acta Histochem.Cytochem.27. 93-106 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seto-Ohshima,A.,Aoki,E.,Omori, A.,Mizutani,A.,Murashima,M.& Heizmann,C.W.: "Parvalbumin immunoreactivity and cytochrome oxidase activity in the brain of the gerbil." Acta Histochem.Cytochem.27. 309-321 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ito,M.: "Barrel field of the prenatally X-irradiated rat somatosensory cortex:A histochemical and electrophysiological study." J.Comp.Neurol.352. 248-262 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Seo-Hiraiwa,M.L,Seto-Ohshima,A.& Kato,K.: "The surface evoked potential and parvalbummin immunoreactivity in the somatosensory cortex of the developing rat." Develop.Psychobiol.(in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Seto-Ohshima,A.: "Review:Calcium-binding proteins in the sentral nervous system." Acta Histochem.Cytochem.27. 93-106 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山田裕一: "ヒト赤血球型AMP deaminase cDNAのクローニングと酵素欠損の遺伝子解析" プリン・プリミジン代謝. 17. 25-32 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yasukazu YAMADA: "A point mutation responsible for human erythrcyte AMP deaminase deficiency." Human Molecular Genetics. 3. 331-334 (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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