Development of the concentration and separation system for multi-compornents by ion-pair phase separation phenomena with fluorosurfactant
| Project/Area Number |
05805068
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
工業分析化学
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| Research Institution | Ibaraki University |
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Principal Investigator |
IGARASHI Shukuro Ibaraki University Faculty of Engineering Assistant Professor, 工学部, 助教授 (70150258)
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| Project Period (FY) |
1993 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Fluoro surfactant / Ion-pair phase separation phenomena / Concentration and separation method for multi-compornents / Physiological activator / Metal chelate |
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| Research Abstract |
New two types of three-phase separation phenomena were found by the charge neutralization of perfluorooctanate ion ; they are amine type in the neutral pH to alkaline solution and that of polar organic solvent in the acidic solution.In this study, the concentration and separation of several kinds of metal-chelate and physiological active substrates have been discussed in detail based on fundamental findings obtained from these phase separation phenomena.In the amine type (e.g.the case in the presence of n-amylamine), threephase separation phenomenon was confirmed in the pH range of 7 to 8.Each phases were successively water phase and two kinds of water-immisible phase (second phase and first phase) from upper side.The homogeneous liquid-liquid extraction method using these phenomena was applied to three components such as L-ascorbic acid, hemogrobin and alpha, beta, gamma, delta-tetrakis (4-trimethylaminophenyl) porphine (TTMAPP) assuming that separate the medical substances in human b
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lood.As the results, they were able to be separated into water (L-ascorbic acid), second (hemoglobin) and first (TTMAPP) phases, respectively using only a one-step process with addition of amylamine to the perfluorooctanoic acid solution.On the other hand, in the polar organic solvent type (e.g.the case in the presence of dimethylsulfoxide), the three-phase separation phenomenon was confirmed in the pH range of 0.42 to 0.46.This extraction method was applied to eight kinds of synthetic water-soluble porphyrin.As the results, three kinds of water-soluble porphyrin was quantitatively extracted and separated in water phase, second phase and first phase, respectively.The structure and physico-chemical property of these solutes is an important as a model when this extraction method is applied to the separation for other solutes.
In conclusion, above-described valuable results for the development of new separation method "multi-compornents homogeneous liquid-liquid extraction"was obtained during the past two years.In the near future, the discovery of novel multi-phase separation phenomenon and the application to the extensive sample containing useful solute would be aggressively done. Less
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Report
(3 results)
Research Products
(6 results)
