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Effects of prostaglandin and noradrenalin on sleep-related neurons in the preoptic area.

Research Project

Project/Area Number 05807006
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionOSAKA BIOSCIENCE INSTITUTE

Principal Investigator

OSAKA Toshimasa  Osaka Bioscinece Institute, Research Scientist, 第2研究部, 研究員 (30152101)

Co-Investigator(Kenkyū-buntansha) HAYAISHI Osamu  Osaka Bioscinece Institute, Director, 所長 (40025507)
MATSUMURA Hitoshi  Osaka Bioscience Institute, Vice Head, 第2研究部, 副部長 (50173886)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
KeywordsSleep / Neuron / Prostaglandin / Noradrenaline / Preoptic area / ラット / 多連微小ピペット / クロニジン
Research Abstract

Electrical stimulation of noradrenergic cells in the locus coeruleus and ventrolateral medulla inhibited sleep-active neurons and excited waking-active neurons in the preoptic area of the rat. Noradrenaline applied through a multibarrel micropipette also inhibited sleep-active neurons and excited waking-active neurons. Application of antagonists and agonists for adrenoceptors revealed that inhibition was mediated by alpha_2-and excitation by alpha_1-receptors.
During wakefulness, prostaglandin D_2 (PGD_2) excited sleep-active neurons and inhibited waking-active neurons. Continuous application of PGD_2 attenuated neuron activity during wakefulness. However, PGD_2 was less effective in eliciting a response during sleep. PGD_2 also attenuated noradrenaline-induced responses of sleep-related neurons.
These results suggest (1) noradrenaline promotes wakefulness by inhibiting sleep-active neurons through alpha_2-receptors and by exciting waking-active neurons through alpha_1-receptors, (2) PGD_2 promotes sleep by exciting sleep-active neurons and by inhibiting waking-active neurons, (3) most important action of PGD_2 is the attenuation of activity during wakefulness, and (4) PGD_2 attenuates the noradrenaline-mediated arousal influence.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Osaka,T.: "Noradrenergic inputs to sleep related neurons in the preoptic area from the locus coeruleus and the ventrolateral medulla in the rat." Neuroscience Research. 19. 39-50 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumura,H.: "Prostaglandin D_2-sensitive,sleep-promoting zone defined in the ventral surface of the rostral basal forebrain." Proceedings of the National Academy of Sciences USA. 91. 11998-12002 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Osaka,T.: "Noradrenaline inhibits preoptic sleep-active neurons through α_2-receptors in the rat." Neuroscience Research. (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Osaka, T.and Matsumure, H.: "Noradrenergic inputs to sleep related neurons in the preoptic area from the locus coeruleus and the ventrolateral medulla in the rat." Neuroscience Research. 19. 39-50 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S.S., Kasahara, K.and Hayaishi, O.: "Prostaglandin D_2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain." Proceedings of the National Academy of Sciences USA. 91. 11998-12002 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Osaka, T.and Matsumura, H.: "Noradrenaline inhibits preoptic sleep-active neurons through alpha_2-receptors in the rat." Neuroscience Research.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Toshimasa Osaka: "Norddrenaline inhibits preoptic sleep-actiue neurons through α2-receptors in the rat" Neuroscience Research. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Toshimasa Osaka: "Noradrenergic inputs to sleep‐nelated neurans in the preoptic area from the locus coeruleus and the ventrolateral medalla in the rat" Neuroscience Research. (1994)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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