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Endothelin Research and Treatment of Cardiovascular Diseases

Research Project

Project/Area Number 05807060
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

KOHNO Masakazu  Osaka City University Medical School, Assistant Professor, 医学部, 講師 (20153489)

Co-Investigator(Kenkyū-buntansha) HIRATA Kazuto  Osaka City University Medical School, Assistant, 医学部, 助手 (50173232)
YASUNARI Kenichi  Osaka City University Medical School, Assistant, 医学部, 助手 (90231646)
KURIHARA Naotsugu  Osaka City University Medical School, Associate Professor, 医学部, 助教授 (00047127)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
KeywordsEndothelin / Hypertension / kidney / Endothelin receptor antagonist / Mesangial cells / Angiotensin II / Spontaneously hypertensive rats / メザンギウム細胞 / トロンビン / PDGF / パゾプレッシン / 心房性Na利尿ペプチド / プロテインカイネースC
Research Abstract

We have previously demonstrated that plasma endothelin levels are increased in human hypertension with renal dysfunction and in experimental models of malignant hypertension. In this study, we found that rat glomerular mesangial cells produce endothelin and angiotensin II or arginine-vasopressin stimulates this production. In addition, we found that glomerular mesangial cells derived from spontaneously hypertensive rats produce a lot of endothelin. Finally, we found that endothelin receptor antagonist reduces blood pressure and improves renal function in experimental models of malignant hypertension. These data suggest that endothelin may be involved in the pathology of malignant hypertension. Endothelin receptor antagonist may be useful or the treatment of malignant hypertension or the treatment for renal dysfunction associated with the development of hypertension.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Kohno M et al.: "Heparine Tnhibits endothelin-1 production in cultured rat mesangial cells" Kidney International. 45. 137-141 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kohno M et al.: "Endothelin modulates the mitogenic effect of PDGF on glomerular mesangial cells" American Journal of Physiology. 266. F894-F900 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kohno M et al.: "Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells" Hypertension. 25. 1185-1190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ikeda M, Kohno M et al.: "Endothelin production in cultured mesangial cells of spontaneously hypertensive rats" Hypertension. 25. 1196-1201 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kohno M et al: "Cardiac natriuretic peptide inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells" Metabolism. 44. 404-409 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ikeda M,Kohno M et al.: "Effect of thrombin and PDGF on endothelin production in cultured mesangial cells derived from spontaneously hyperensive rats." Clinical and Experimental Pharmacology and Physiology. Suppl 1. S197-S198 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 河野雅和: "現代医療" 中尾一和, 6 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 河野雅和: "現代医療" 眞崎知生, 13 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, T Horio, M Ikeda, N Kurihara, AK Mandal, T Takeda: "Heparin inhibits endothelin-1 production in cultured rat mesangial cells" Kidney International. 45. 137-142 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Kohno, T Horio, K Yokokawa, K Yasunari, N Kurihara, T Takeda: "Endothelin modulates the mitogenic effect of PDGF on glomerular mesangial cells" American Journal of Physiology. 266. F894-F900 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Kohno, H Kano, T Horio, K Yokokawa, K Yasunari, T Takeda: "Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cell migration" Hypertension. 25. 1185-1190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Ikeda, M Kohno, T Takeda: "Endothelin production in cultured mesangial cells of spontaneouslyhypertensive rats" Hypertension. 25. 1196-1201 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, AK Mandal, T Horio, K Yasunari, T Takeda: "Cardiac natriuretic peptide inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells" Metabolism. 44. 404-409 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M Ikeda, Kohno M,T Horio, K Yasunari, H Kano, M Minami, T Hanehira, T Fukui, T Takeda: "Effect of thrombin and PDGF on endothelin production in cultured mesangial cells derived from spontaneously hypertensive rats" Clinical and Experimental Pharmacology and Physiology. Suppl.1. S197-S198 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kohno M et al.: "Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells" Hypertension. 25. 1185-1190 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeda M,Kohno M et al: "Endothelin production in cultured mesangial cells of Spontanecusly hypertensive rats" Hypertension. 25. 1196-1201 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kohno M et al: "Cardiac natriuretic peptide innibit cyclosporine-induced production of endothelin in cultured rat mesangial cells" Metabolism. 44. 404-409 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeda M,Kohno M et al.: "Effect of thrombin and PDGF on endcthelin production in cultured mesangial cells derived from spontaneously hypertensive rats" Clinical and Experimental Pharmacology and Physiology. Suppl.1. S197-S198 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 河野 雅和: "現代医療" 中尾一和, 6 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 河野 雅和: "現代医療" 眞崎知生, 13 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Masakazu Kohno et al.: "Endothelin modulates the mitogenic effect of PDGF on glomeralar mesangl ceii" Am J Physiol.266. F894-F900 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masakazu Kohno et al.: "Heparin inhibit endothelin-i production in cultured rat mesangial cells." Kidney Int.45. 137-142 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masakazu Kohno et al.: "Stimulation of cydic adencsine monohosphate formation by the novelvasorelaxant peptide adrenomedullin cultured rat mesangial cells" Metabolism. 44(i). 10-12 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 河野雅和: "エンドセリンと血圧" 最新医学. 49(3). 8-16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Miwako Ikeda,Masakazu Kohno et al.: "Endcthelin production cultured mesangial cells of sportanecusly nypertensive rats" Hypertension. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Masakazu Kohno et al.: "Inhibition of endothelin production by adrenomedullin in the vascular smooth muscie cells" Hypertension. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Kohno M, Horio T, Ikeda M et al.: "Natriuretic peptides inhibit mesangiul cell production of endothelin induced by arginine vasopressin" Am. J. physiol.33. F678-F683 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kohno M. Ikeda M, Horio T et al.: "Interaction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretion" Am. physiol. physiol.265. E673-E679 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kohno M, Yokokawa K, Horio T et al.: "Effect of endothelin receptor antagonist, Balpha-123, on. Ca^<2+> signaling in cultured rat mesangial cells" Life Sciences. 53. 1631-1641 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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