• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation on molecular markers for assessment of biological activity in prostate cancer

Research Project

Project/Area Number 05807146
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

EGAWA Shin  Assistant Professor, Department of Urology, Kitasato University School of Medicine, 医学部, 講師 (60160347)

Co-Investigator(Kenkyū-buntansha) KOSHIBA Ken  Professor and Chairman, Department of Urology, Kitasato University, School of Me, 医学部, 教授 (40050380)
KUWAO Sadahito  Associate Professor, Department of Pathology, Kitasato University, School of Med, 医学部, 助教授 (70137925)
UCHIDA Toyoaki  Assistant Professor, Department of Urology, Kitasato University, School of Medic, 医学部, 講師 (70146489)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Keywordsprostate cancer / biological significance / genomic instability / DNA ploidy / Transforming growth factor beta 1 / 進行因子 / 分子生物学的マーカー / DNA-ploidy / microsatellite instability / 人種差 / 遺伝子 / 迫行性病変
Research Abstract

The frequent detection of clinically silent prostate cancer in autopsy studies suggests a benign natural history of the disease in some men, but more aggressive and potentially lethal cancers in others. In order to determine molecular markers for progression, genomic instability of microsatellites repeats, DNA ploidy status and serum transforming growth factor beta 1 levels were investigated for their usefulness to predict more aggressive phenotype. Sixty-six patients with prostate adenocarcinoma were screened for somatic instability at 8 microsatellite marker loci on 5 chromosomes. Genomic instability was detected in 13 (19.7%) patients. Extraglandular spread was found to show significant association with somatic instability after controlling for other clinicopathological variables. It was suggested that polymerase chain reaction based microsatellite instability assay may serve as a useful molecular prognostic marker in prostate cancer. DNA ploidy of each focus of a cancer in 70 radical prostatectomy specimens was determined by nuclear image analysis. Of the 103 individual cancers, 64 (62%) were nondiploid. DNA ploidy was weakly correlated with increase in tumor volume but not tumor grade. The relationship between DNA ploidy and extraprostatic spread was not statistically significant. Serum levels of transforming growth factor beta 1 were correlated with tumor grade and stage in 260 patients with prostate cancer. There was no correlation seen between these variables

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Shin Egawa et al.: "Genomic instability of micro satellite repeats in prostate cancer relationship to clinicopathological variables" Cancer Research. 55. 2418-2421 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shin Egawa et al.: "Deoxyribonucleic acid ploidy status as no basis for pathologic stage prediction in clinically resectable prostate cancer" Urology. 47(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shin Egawa et al.: "Risk of progression and dying of clinically localized prostate cancer in Japan" World J Urol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shin Egawa et al.: "Deoxyribonucleic acid ploidy ststus as no basis for pathologic stage prediction in clinically resectable prostate cancer" Urology. 47 (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shin Egawa et al.: "Risk of progression and dying of climically localized prostate cancer in Japan" World J Urol. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] 頴川 晋,他: "Stage Tlc前立腺癌の臨床的重要性。" 泌尿器外科. 8. 93-101 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Uchida T,Egawa S,et al: "Microsatellite instability in prostate cancer." Oncogene in press.

    • Related Report
      1994 Annual Research Report
  • [Publications] 頴川 晋,他: "直腸診,画像診断では検出できない前立腺癌(Tlc癌)の臨床病理学的検討" Jpn.Urol.(in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Toyoaki Uchida, Shin Egawa,et al.: "INFREQUENT IN VOLVEMENT OF p53 MUTATIONS ANDLOSS OF HETEROZYGOSITY OF 17p IN THE TUMORIGENESIS OF RENAL CELL CARCINOMA" THE JOURNAL OF UROLOGY. 150. 1298-1301 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Uchida,Shin Egawa et al.: "Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer." Br.J.Cancer. 68. 751-755 (1993)

    • Related Report
      1993 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi