| Project/Area Number |
05807167
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
小児外科
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHIDA Hideo CHIBA UNIVERSITY SCHOOL OF MEDICINE, 医学部付属病院, 助手 (60210712)
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Masahiro CHIBA UNIVERSITY SCHOOL OF MEDICINE, 医学部付属病院, 講師 (10207160)
OHNUMA Naomi CHIBA UNIVERSITY SCHOOL OF MEDICINE, 医学部, 助教授 (50125910)
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| Project Period (FY) |
1993
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | neuroblastoma / omega3 fatty acid / PGE 2 / procoagulant activity / hepatic metastasis |
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| Research Abstract |
In recent years, diet and nutritional factors are considered to be of major importance in the cancer developing with a multistage process and in the unregulated proliferation of malignant cells.
The lipid composition of cell membranes is dependent to a great extent on the composition of the diet. The membrane lipid structual changes may alter physicochemical characteristics of membrane and thereby alter cellular functios. We evaluated the in vivo antimetastatic activity of omega3 fatty acids in murine neuroblastoma.
Experimental hepatic metastasis of C-1300 neuroblastoma were markdly reduced by treatment with omega3 fatty acid.
Liver-carcass ratios were decreased. Histrogical findings showed that hepatic metastasis was suppressed. There was a decrease in levels of PGE2 and Procoagulant activity with omega3 fatty acid treatment. These results demonstrated that omega3 fatty acids have potent in vivo antimetastatic effects against neuroblastoma.
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