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Ageing mechanisms of hemopoietic system in senescence accelerated (SAM-P) mice.

Research Project

Project/Area Number 05834004
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 老化(加齢)
Research InstitutionNiigata University

Principal Investigator

MORI Kazuhiro  Niigata University, Faculty of Science, Professor, 理学部, 教授 (90025635)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Kenkichi  Niigata University, Faculty of Science, Associate Prof., 理学部, 助教授 (20240765)
Project Period (FY) 1993 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAgeing / SAM-P mice / Hemopoiesis / Spleen / Cytokines / Hemopoietic microenvironment / Hemopoietic Stem Cells / 異系骨髄移植 / IL-6
Research Abstract

Senescence accelerated (SAM-p) mice show a significant decrease in the number of peripheral blood cells with age. Mutual bone marrow transplantation between young and old mice of this strain revealed that the differentiation-supporting function of the spleen of the old mice was less active than that in the young mice.
To elucidate the possible decrease in cytokine production by the hemopoietic microenvironmet of the old mice, we have assayd the production of granulocyte-macrophage colony stimulating factor (GM-CSF) in the young and old SAM-P mice.
Old mice produced much less GM-CSF compared to young mice. Degree of the response to IL-E stimulation, which is known to induce GM-CSF production by the murine bone marrow cells, was not different between young and old mice, although the total amount of GM-CSF was less in the old mice than that in the young mice in this case, as well.
There was no difference in the level of interleukin-6 production between young and old mice.
These results suggest that age-related decrease in cytokine production is responsible for the decreased production of peripheral blood cells in the old SAM-P mice.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report

Research Products

(21 results)

All Other

All Publications (21 results)

  • [Publications] Hisha-Izumi,H.: "Age-related decrease in the number of hemopoietic stem cells in senescence accelerated (SAM-P) mice." Mech.Ageing Dev.56. 89-97 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuboi,T.: "Age-related changes in various hemopoietic progenitor cells in senescence accelerated (SAM-P) mice." Exp.Hematol.19. 874-877 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuji,T.: "Induction of GM-CSF and G-CSF expression in bone marrow and fractionated marrow cell populations by IL-3." Growth Factors. 11. 77-79 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yanai,T.: "Constitutive production of IL-6 in the anemic mice of W/W^v genotype." Leuk.Res.18. 123-131 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sakuma,A.: "Age-related decreases in the reconstituting ability of hemopoietic cells and the ability of hemopoietic microenvironment......." Mech.Ageing Dev.73. 127-135 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森和博: "老化モデルマウス(SAM-P)における幹細胞老化と癌化" 基礎老化研究. 18. 10-22 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hisha-Izumi, H.: "Age-related decrease in the number of hemopoietic stem cells in senescence accelerated (SAM-P) mice." Mech.Ageing Dev.56. 89-97 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuboi, T.: "Age-related changes in various hemopoietic progenitor cells in senescence accelerated (SAM-P) mice." Exp.Hematol.19. 874-877 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuji, T.: "Induction of GM-CSF and G-CSF expression in bone marrow and fractionated marrow cell populations by IL-3." Growth Factors. 11. 77-79 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yanai, T.: "Constitutive production of IL-6 in the anemic mice of W/W^v genotype." Leuk.Res.18. 123-131 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sakuma, A: "Age-related decreases in the reconstituting ability of hemopoietic cells and the ability of hemopoietic microenvironment to support hemopoietic reconstitution in senes-cence accerlerated (SAM-P) mice." Mech.Ageing Dev. 73. 127-135 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hisha-Izumi,H.: "Age-related decrease in the number of hemopoietic stem cells in senescence accelerated (SAM-P)mice." Mech.Ageing Dev.56. 89-97 (1990)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsuboi,T.: "Age-related changes in various hemopoietic progenitor cells in senescence accelerated (SAM-P)mice" Exp.Hematol.19. 874-877 (1991)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsuji,T.: "Induction of GM-CSF andG-CSF expression in bone marrow and fractionated marrow cell populations by IL-3." Growth Factors. 11. 77-79 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yanai,T.: "Constituive production of IL-6in the anemic mice of W/W genotype." Leuk.Res.18. 123-131 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sakuma,A.: "Age-related decresases in the reconstituting ability of hemopoietic cells and the ability of hemopoietic microenvironment....." Mech.Ageing Dev.73. 127-135 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森 和博: "老化モデルマウス(SAM-P)における幹細胞老化と癌化" 基礎老化研究. 18. 10-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroko Hisha-Izumi: "Age-related decrease in the number of hemopoietic stem cells in senescence accelerated(SAM-P)mice." Mech.Ageing Dev.56. 89-97 (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isao Tsuboi: "Age-related changes in various hemopoietic progenitor cells in senescence accelerated(SAM-P)mice." Exp.Hematol.19. 874-877 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Atsushi Sakuma: "Age-related decreases in the reconstituting ability of hemoopoietic cells and the ability of hemopoietic microenvironment to support hemopoietic reconstitution in senescence accelerated(SAM-P)mice." Mech.Ageing Dev.(in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] 森和博: "老化モデルマウス(SAM-P)における幹細胞老化と癌化" 基礎老化研究. (in press).

    • Related Report
      1993 Annual Research Report

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Published: 1993-03-31   Modified: 2016-04-21  

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