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Etiological and epidemiological study of Moyamoya disease or its equivqlents in the People's Republic of China

Research Project

Project/Area Number 06041137
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MATSUSHIMA Yoshiharu  Department of Neurosurgery, Asociate Professor, 医学部・脳外科助教授 (20134679)

Co-Investigator(Kenkyū-buntansha) 銭 亮  東京医科歯科大学, 医学部, 脳外科大学院生
AOYAGI Masaru  Department of Neurosurgery, Assistant Professor, 医学部, 脳外科講師 (40134704)
TIAN Quain  Postgraduate course, Student
Project Period (FY) 1994
Project Status Completed (Fiscal Year 1994)
KeywordsMoyamoya disease / Moyamoya syndrome / Moyamoya equivalents / leptospiral infection / hereditary factors / The People's Republic of China / Tonji Hospital in Wuhan / Beijing Neurosurgical Institute
Research Abstract

It was revealed that epidemiological differences between Moyamoya disease observed in Japan and Moyamoya disease and/or Moyamoya-like disease in the People's Republic of China were very much due to the differences in socioeconomic circumstances in both countries and that it was difficult to compare the differences just from medical point of view.
We ocmpared, therefore, the objective angiographical findings among Moyamoya disease in Japan, so-called Moyamoya disease in Beijing and Moyamoya syndrome in Wuhan and concluded that they were identical angiographically.
We, thus, hypothetically concluded that Moyamoya disease in Japan, so-called Moyamoya disease in Beijing and Moyamoya syndrome in Wuhan were on the same line of a disease entity and that the primary arterial lesion observed in these diseases seemed to be due to hereditary factors, ex-trinsic factors and anatominco-rheological factors.
Hereditary factors seems to take more part in Moyamoya disease in Japan and extrinsic factors of leptospiral angitis seems to take more part in Moyamoya syndrome in Wuhan in the development of primary arterial lesion observed in those diseases.

Report

(1 results)
  • 1994 Final Research Report Summary
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] Nariai T,Suzuki R,Matsushima Y,Ichimura Y,Hirakawa K,Ishii K,Senda M: "Surgically induced angiogenesis to compensate for hemodynamic cerebral ischemia." Stroke. 25. 1014-1021 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、脇本浩明 成相直、高田義章、長島悟郎 鈴木龍太、大野喜久郎、平川公義: "小児モヤモヤ病にたいするEncephaloduro-arterio-synangiosisの手術手技に付いて-II.統計学的観察" 小児の脳神経. 19. 277-284 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、長岡司 成相直、平川公義: "小児モヤモヤ病においてdual EDASが必要な症例はどの様な症例か" 小児の脳神経. 19. 299-304 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 青柳傑、深井直実、尾上和夫 松島善治、山本満里、山本清高: "モヤモヤ病患者由来血管平滑筋細胞のTGF-β1に対する増殖反応性" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 平成5年. 45-47 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、鈴木龍太 成相直、平川公義: "一側性小児モヤモヤ病の存在と片側性ウィリス動脈輪閉塞症にたいする間接的血管吻合術の手術適応について" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 平成5年. 57-64 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukai N,Aoyagi M,Yamamoto M,Sakamoto H,Ogami K,Matsushima Y,Yamamoto K: "Human arterial smooth muscle cell strains derived from patints with moyamoya disease: Changes in biological characteristics and proliferative response during cellular aging in vitro" Mechanism of Aging and Development. 75. 21-33 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、長岡司 成相直、前原健寿、高田義章 鈴木龍太、大野喜久郎、平川公義: "Encephalo-duro-arterio-synangiosis(EDAS)の術後に追加間接的血管吻合術を要した小児モヤモヤ病症例の検討" 小児の脳神経. 19. 403-410 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高田義章、松島善治、青柳傑、太田禎久、大野喜久郎、平川公義: "先天性毛細血管拡張性大理石皮膚を伴ったモヤモヤ病の2症例" 小児の脳神経. 19. 423-427 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治: "モヤモヤ病に対する最近の手術法" Clinical Neuroscience. 13. 242-243 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Aoyagi M,Ogami K,Matsushima Y Shikata M,Yamamoto M & K: "Moyamoya disease is associated with human leukocyte antigen-B51" Stroke. 26(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、山口武兼、高田義章、有光佳子: "レプトスピラ症の血清学的診断法-マイクロ・カプセル凝集反応-によるモヤモヤ病患者血清の検討" 平成6年度科学研究費補助金(国際学術調査)研究成果報告書:中国におけるモヤモヤ病または類似疾患の病因並びに疫学的調査. 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Li B,Sun YL,Li GL,Li DZ,Wang CC,Matsushima Y: "A Histopathological,ultrastructural and immunohistochemical study on superficial temporal aeteries in children with Moyamoya disease" 平成6年度科学研究費補助金(国際学術調査)研究成果報告書:中国におけるモヤモヤ病または類似疾患の病因並びに疫学的調査. 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Qian L,Aoyagi M: "Comparison of Moyamoya disease in Japan and Moyamoya disease(or syndrome)in China" 平成6年度科学研究費補助金(国際学術調査)研究成果報告書:中国におけるモヤモヤ病または類似疾患の病因並びに疫学的調査. 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y: "Surgical procedure of encephalo-duro-arterio-synangiosis in the treatment of Moyamoya disease in childhood" 平成6年度科学研究費補助金(国際学術調査)研究成果報告書:中国におけるモヤモヤ病または類似疾患の病因並びに疫学的調査. 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治、青柳傑、成相直: "EDASを施行後10年以上経過した小児モヤモヤ病患者の知能予後" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大沢真木子、今泉友一、松島善治: "小児ウィリス動脈輪閉塞症の知能予後に関する研究-外科的治療群と内科的治療群の比較" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 青柳傑、松島善治、成相直: "小児モヤモヤ病の浅側頭動脈内膜肥厚の特徴像" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 成相直、松島善直、青柳傑: "成人モヤモヤ病に対する間接的血行再建術の適応と効果" 厚生省特定疾患ウィリス動脈輪閉塞症調査研究班平成5年度研究報告書、(福井仁士編). 1994(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木龍太、平塚秀雄 松島善治、稲葉穣: "Xenon-enhanced CTによる局所脳 血流(rCBF)測定(脳神経CT最近の進歩)" にゅ-ろん社、東京, 111-115 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 松島善治: "モヤモヤ病(ウィリス動脈輪閉塞症)-脳神経外科から(亀山正邦、高倉公明(編)今日の神経疾患治療指針)" 医学書院、東京, 214-216 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nariai T,Suzuki R,Matsushima Y,Ichimura Y,Hirakawa K,Ishii K,Senda M: "Surgically induced angiogenesis to compensate for hemodynamic cerebral ischemia." Stroke. 25. 1014-1021 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Wakimoto H,Nariai T,Takada Y,Nagashima G,Suzuki R,Ohno K,Hirakawa K: "Operative procedures of encephalo-duro-arterio-synangiosis (EDAS) for the treatment of Moyamoya disease in children-2. Statistical observation." Child Nerve Syst (Kobe). 19. 277-284 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Nagaoka T,Nariai T,Hirakawa K: "Pediatric Moyamoya patients that need dual EDAS" Child Nerve Syst (Kobe). 19. 299-304 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Aoyagi M,Fukai N,Onogami K,Matsushima Y,Yamamoto M & K: "Prolifertive reactivity of arterial smooth muscle derived from pediatric Moyamya patients to TGF-beta1" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1993. 45-47 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Suzuki R,Nariai T,Hirakawa K: "Entity of unilateral pediatric Moyamoya patients and indications of indirect anastomosis for the treatment of one sided Moyamoya disease" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1993. 57-64 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukai N.Aoyagi M,Yamamoto M,Sakamoto H,Ogami K,Matsushima Y,Yamamoto K: "Human arterial smooth muscle cell strains derived from patients with moyamoya disease : Changes in biological characteristics and proliferative response during cellular aging in vitro" Mechanism of Aging and Development. 75. 21-33 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Nagaoka T,Nariai T,Maehara T,Takada Y,Suzuki R,Ohno K,Hirakawa K: "Pediatric Moyamoya patients who needed additional indirect anastomoses after encephalo-duro-arterio-synangiosis" Child Nerve Syst (Kobe). 19. 403-410 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takada Y,Matsushima Y,Aoyagi M,Ohta Y,Ohno K,Hirakawa K: "Two pediatric Moyamoya cases with congenital cutis marmorata" Child Nerve Syst (Kobe). 19. 423-427 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y: "Recent surgery to treat Moyamoya disease" Clinical Meuroscience. 13. 242-243 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Aoyagi M,Ogami K,Matsushima Y,Shikata M,Yamamoto M & K: "Moyamoya disease is associated with human leukocyte antigen-B51" Stroke. 26 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Yamaguchi T,Takada Y,Arimitu Y: "Leptospiral serum examination of Moyamoya patients by microcapsular agglutination test" Report of International Field Research Program, 1994 Etiological and epidemiological study of Moyamoya disease or its equivqlents in the People's Republic of China. 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Li B,Sun YL,Li GL,Li DZ,Wang CC,Matsushima Y: "A Histopathological, ultrastructural and immunohistochemical study on superficial temporal aeteries in children with Moyamoya disease" Report of International Field Research Program, 1994 Etiological and epidemiological study of Moyamoya disease or its equivqlents in the People's Republic of China. 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Qian L,Aoyagi M: "Comparison of Moyamoya disease in Japan and Moyamoya disease (or syndrome) in China" Report of International Field Research Program, 1994 Etiological and epidemiological study of Moyamoya disease or its equivqlents in the People's Republic of China. 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y: "Surgical procedure of encephalo-duro-arterio-synangiosis in the treatment of Moyamoya disease in childhood" Report of International Field Research Program, 1994 Etiological and epidemiological study of Moyamoya disease or its equivqlents in the People's Republic of China. 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y,Aoyagi M,Nariai T: "Inntelligence of pediatric Moyamoya patients who have had EDAS more than 10 years" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohsawa M,Imaizumi Y,Matsushima Y: "Study of intelligence prognosis in pediatric Moyamoya patients -Comparison between surgical and medical treatments-" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Aoyagi M,Matsushima Y,Nariai T: "Characteristics of arterial epithelial thickening in superficial temporal arteries of pediatric Moyamoya patients" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nariai T,Matsushima Y,Aoyagi M: "Indications and effects of indirect nanstomosis on adult Moyamoya patients" Annual report of national committee of spontaneous occlusion of the circle od Willis (edited by Fukui H). 1994 (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suzuki R,Hiratsuka H,Matsushima Y,Inaba Y: Neuron Co., Tokyo. Regional cerebral blood flow examination by Xenon-enhanced CT, 111-115 (1994 (1985))

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsushima Y: Igakushoin Tokyo. Moyamoya disease (Spontaneous occlusion of Willis's arterial ring) -from neurosurgicsl point of view-, 214-216 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary

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Published: 1996-04-15   Modified: 2016-04-21  

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