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Cooperation and information exchange with European countries.

Research Project

Project/Area Number 06042002
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionShowa University (1996)
The University of Tokyo (1994-1995)

Principal Investigator

KUROKI Toshio  Institute of Molecular Oncology, Showa University, 腫瘍分子生物学研究所, 所長 (90006073)

Co-Investigator(Kenkyū-buntansha) SONODA Toshio  Faculty of Medicine, Kagoshima University, 医学部, 教授 (40036463)
OKADA Masato  Institute of Protein Research, Osaka University, 蛋白質研究所, 助教授 (10177058)
TOMINAGA Akita  Kochi Medical School, 教授 (50172193)
MIYASAKA Masayuki  Osaka University School of Medicine, 医学部, 教授 (50064613)
TSUJIMOTO Yoshihide  Osaka University School of Medicine, 医学部, 教授 (70132735)
MATSUMOTO Kunihiro  Faculty of Science, Nagoya University, 大学院・理学研究科, 教授 (70116375)
NISHIKAWA Shin-ichi  Faculty of Medicine, Kyoto University, 大学院・医学研究科, 教授 (60127115)
ISHIBASHI Masahide  Research Institute, Aichi Cancer Center, 研究所, 部長 (70029776)
YASUMOTO Shigeru  Kanagawa Cancer Center Research Institute, 研究所, 室長 (00112342)
MURAKAMI Yoshinori  National Cancer Center Research Institute, 研究所, 室長 (30182108)
AIBA Atsushi  Institute of Medical Science, University of Tokyo, 医学科研究所, 助教授 (20271116)
SHIBUYA Masabumi  Institute of Medical Science, University of Tokyo, 医科学研究所, 教授 (10107427)
HIRAI Hisamaru  Faculty of Medicine, University of Tokyo, 医学部, 助教授 (90181130)
NAGATA Kyosuke  Dept.of Biomol.Engineering, Tokyo Institute of Technology, 生命理工, 助教授 (40180492)
NODA Tetsuo  Cancer Institute, 研究所, 部長 (10183550)
SUGAMURA Kazuo  Faculty of Medicine, Tohoku University, 医学部, 教授 (20117360)
TAKADA Kenzo  Faculty of Medicine, Hokkaido University, 医学部, 教授 (30133721)
豊島 久真男  大阪府立成人病センター, 総長 (90029760)
野村 慎太郎  大阪大学, 医学部, 助教授 (80159087)
菅野 晴夫  癌研究所, 癌化学療法センター, 所長 (10085615)
貝淵 弘三  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (00169377)
菊谷 仁  大阪大学, 細胞生体工学センター, 助教授 (80161412)
菅野 純夫  東京大学, 医科学研究所, 助教授 (60162848)
宮園 浩平  癌研究所, 部長 (90209908)
松居 靖久  東北大学, 加齢医学研究所, 助教授 (40241575)
小川 勝洋  旭川医科大学, 教授 (50045514)
山本 雅之  筑波大学, 基礎医学系 先端学際領域研究センター, 教授 (50166823)
藤永 恵  札幌医科大学, がん研究所, 教授 (10045338)
葛西 宏  産業医科大学, 産業生態科学研究所, 教授 (40152615)
沖 俊一  富山県立大学, 工学部, 教授 (40264676)
田中 亀代治  大阪大学, 細胞生体工学センター, 教授 (80144450)
関口 睦夫  九州大学, 生体防御医学研究所, 教授 (00037342)
斉藤 隆  千葉大学, 医学部, 教授 (50205655)
増井 徹  京都大学, 医学部, 助手 (50150082)
前田 浩  熊本大学, 医学部, 教授 (90004613)
千田 和弘  東京大学, 医科学研究所, 助手 (00192188)
大野 茂男  横浜市立大学医学部, 教授 (10142027)
西田 栄介  京都大学ウイルス研究所, 教授 (60143369)
秋山 徹  大阪大学微生物病研究所, 教授 (70150745)
田中 信之  大阪大学細胞生体工学センター, 講師 (80222115)
山本 雅  東京大学, 医科学研究所, 教授 (40134621)
清木 元治  金沢大学, がん研究所, 教授 (10154634)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥25,400,000 (Direct Cost: ¥25,400,000)
Fiscal Year 1996: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1995: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1994: ¥8,400,000 (Direct Cost: ¥8,400,000)
Keywordscell growth / cell differentiation / apoptosis / signal transduction / cell-cell interaction / cancer metastasis / human cancer / oncogene / tumor suppressor gene / がん細胞 / DNA修復 / ヒトゲノム / 2国間共同研究
Research Abstract

To promote exchange of information, materials and expertise in cancer research, 15 to 20 scientists are sent to reputed institutes or universities in European countries. In particular, this program has supported the Japanese-German and the Japanese-French Collaborative programs in cancer research and organized workshops every year.
In the fiscal year of 1996, the German-Japanese Workshop was held on 26-27 September 1996 at the German Cancer Center, Heidelberg, Germany. The workshop was entitled "Viral contributions to human cancer". From Japan, following scientists participated by the support of this grant : K.Takada (Hokkaido Univ.), K.Sugamura (Tohoku Univ.), K.Nagata (Tokyo Inst.Technology), M.Ishibashi (Aichi Cancer Center) and T.Sonoda (Kagoshima Univ.).
The French Japanese workshop was held on September 17-20,1996 at the Pasteur Institute, Lille, under the title of "Molecular and cellular basis for tumor-host relationship", in which the follwing Japanese scientists participated : T.Kuroki (Showa Univ.), H.Hirai, M.Shibuya, A.Aida (Univ.of Tokyo), K..Matsumoto (Nagoya Univ.), S.Nishikawa (Kyoto Univ.), M.Miyasaka, Y.Tsujimoto, and M.Okada (Osaka Univ.).
In addition to the above collaborative programs, follwing four scientists were sent to Europe to exchange information and materials : T.Noda (Cancer Inst.), Y.Murakami (Nat.Cancer Center Res.Inst.), S.Yasumoto (Kanagawa Cancer Center Res.Inst.), and A.Tominaga (Kochi Med.Univ.).

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (46 results)

All Other

All Publications (46 results)

  • [Publications] Kuroki, T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Int.J.Cancer. 66. 1-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, N.: "Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cells." Journal of Virology. 70. 7260-7263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kawase, H.: "NAP-I is a functional homologue of TAF-I that is required for replication and transcription of the adenovirus genome in a chromatin-like structure." Genes to Cells. 1. 1045-1056 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yasumoto, S.: "Telomerase activity in normal human epithelial cells." Oncogene. 13. 433-439 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, S.: "Bcl-1 expression prevents activation of the ICE protease cascade." Oncogene. 12. 2251-2257 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takayama, Y.: "Role of Csk in neural differentiation of the embryonic carcinoma cell line P19." FEBS Letters. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, H.: "Dopamine D2 receptor plays a critical role in cell proliferation and pro-opiomelanocortin expression in the pituitary." Genes to Cells. 1. 253-268 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wakiya, K.: "A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (Vascular endothelial growth factor receptor 1) gene." J.Biological Chemistry. 271. 30823-30828 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujita, M.: "hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase." J.Biological Chemistry. 271. 4949-4954 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroki,T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Int.J.Cancer. 66. 1-5 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu,N.: "Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cells." Journal of Virology. 70. 7260-7263 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawase,H.: "NAP-I is a functional homologue of TAF-I that is required for replication and transcription of the adenovirus genome in a chromatin-like structure." Genes to Cells. 1. 1045-1056 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yasumoto,S.: "Telomerase activity in normal human epithelial cells." Oncogene. 13. 433-439 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu,S.: "Bcl-2 expression prevents activation of the ICE protease cascade." Oncogene. 12. 2251-2257 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takayama,Y.: "Role of Csk in neural differentiation of the embryonic carcinoma cell line.P19." FFBS Letters. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamaguchi,H.: "Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary." Genes to Cells. 1. 253-268 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Wakiya,K.: "A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (Vascular endothelial growth factor receptor 1) gene." J.Biological Chemistry. 271. 30823-30828 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujita,M.: "hCDC47,a human member of the MCM family. Dissociation of the nucleus-bound form during S phase." J.Biological Chemistry. 271. 4949-4954 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Chida,K.: "Cholesterol sulfate,a second messenger for the eta isoform of protein kinase C,inhibits promotional phase in mouse skin carcnogenesis." Cancer Res.55. 4865-4869 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kakuma,T.: "Mouse MTH1,protein with 8-oxo-7,8-dihydro-2-deoxyquanosine 5-triphosphatase activity that prevents transversion mutation." J.Biol.Chem.270. 25942-25948 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakane,H.: "High incidence oof ultraviolet-B-or chemical-carcinogen-induced skin tymours in mice lacking the xeroderma pigmentosum group A gene." Nature. 377. 165-168 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakai,S.: "The POU domain transcription factor Brn-2 is required for the determi-nation of specific neuronal lineages in the hypothalamus of the mouse." Genes & Development. 9. 3109-3121 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamamoto,S.: "Screening and production of aryl-sulfatases for target therapy with etoposide 4-sulfate,an antitumor prodrug." Biosci.Biotech.Biochem.59. 1057-1061 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kamiya,H.: "Formation of 2-hydroxydeoxyadenosine triphosphate,an oxidatively damaged nucleotide,and its incorporation by DNA polymerases." J.Biol.Chem.270. 19446-19450 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shimizu,S.: "Prevention of hypoxia-induced celldeath by Bcl-2 and Bcl-xl." Nature. 374. 811-813 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kaya,M.: "A single ets-related transcription factor,ElAF,confers invasive phenotype on human cancer cells." Oncogene. 12. 221-227 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Igarashi,K.: "Conditional expression of the ubi-quious transcription factor MafK induces erythroleukemia cell differentiation." Proc.Natl.Acad.Sci.USA. 92. 7445-7449 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Saito,Y.: "Wild type p53 and c-myc co-opera-tion in generating apoptosis of a rat hepatocellular carcinoma cell line (FAA-HTCl)." Oncogene. 11. 1013-1018 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kuroda,S.: "Purification and characterization of REKS from Xenopus eggs. Identi-fication of reks as a Ras-dependent mitogen-activated protein kinase kinase kinase." J.Biol.Chem.270. 2460-2465 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokoyama-Kobayashi,M.: "A signal sequence detection systemusing secreted protease activity as an indicator." Gene. 163. 193-196 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsubara,N.: "Murine polo like kinase l gene is expressed in meiotic testicular germ cells and oocytes." Molecular Reproduction and Development. 41. 407-415 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawabata,M.: "Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-α." J.Biol.Chemistry. 270. 29628-29631 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takebayashi,K.: "Recessive phenotype displayed by adominant negative microphthalmia-associated transcri ption factor mutant is a result of impaired nu-clear localization potential." Mol.Cell.Biol.in-press (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yukawa,K.: "Regulation of human papillomavirus transcription by the differentiation-dependent epithelial factor Epoc-l/skn-la." J.Virol.70. 10-16 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takeshima,H.: "Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene." Nature,. 369. 556-559 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Chida,K.: "The η isoform of protein kinase C is localized on rough endoplasmic reticulum." Mol.Cell.Biology. 14. 3782-3790 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirai,S.: "Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP-l/Jun by PKCδ." EMBO J.13. 2331-2340 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Maeda,H.: "Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthetase inhibitor." Jpn.J.Cancer Res.85. 331-334 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohno,H.: "Targeted disruption ofthe CD3η locus causes high lethality in mice: modulation of Oct-l transcription on the opposite strand." Embo J.13. 1157-1165 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masui,T.: "Establishment of an outgrowth culture system to study growth regulation of normal human epithelium." In Vitro Cell.& Animal Developmental Biology. (in press). (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohara,R.: "Identification of the cells expressing cot proto-oncogene mRNA." J.Cell Science. 108. 97-103 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fujimoto,M.: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentially expressed in the brain." Oncogene. 9. 693-698 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tanaka,N.: "Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-l." Cell. 77. 829-839 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sato,H.: "A matrix metalloproteinase expressed on the surface of invasive tumor cells." Nature. 370. 61-65 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kamada,S.: "Serum-independent phosphorylation of c-Jun and alterations in AP-l components bytransformation with various oncogenes." J.Biol.Chemistry. 269. 4565-4570 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kosako,H.: "Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation." EMBO J.13. 2131-2138 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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