| Project/Area Number |
06042005
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Niigata University |
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Principal Investigator |
WATANABE Hidenobu Niigata University School of Medicine Professor, 医学部, 教授 (70037381)
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| Co-Investigator(Kenkyū-buntansha) |
ROA Ivan Temuco Hospital, Chief La.Furontera University School of Medicine Professer, フロンテラ大学, 部長教授
SERRA Ivan Chile University School of Medicine Professer, 医学部, 教授
CALVO Alfonso Sotero del Rio Hospital Chief, デル・リオ病院, 部長
SUGANUMA Masami Saitama Cancer Center Department of Immunology and Virology Research Associate, 血清ウイルス, 主任 (20196695)
TAJIMA Kazuo Aichi cancer Resarch Institute. Division of Epidemiology, Chief, 疫学部, 部長 (30150212)
YAMAMOTO Masaharu Niigata University School of Medicine Professor, 医学部, 教授 (40018693)
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| Project Period (FY) |
1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1994: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | Gallbladder / Cancer / Japan / Chile / p53 protein / Carcinogens / Pathology / Epidemiology / Biochemistry |
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| Research Abstract |
We have been doing comparative study on gallbladder cancer from 1992 between Japanese (in Niigata) and Chilean (in Santiago or Temuco).
In the past two-year research, we found a significant difference in p53 immunoreactive protein overexpression between carcinomas from two countries.
In 1994 we put a focus of our research on other gene alterations to know what kinds of gene abnormalities are developing in carcinogenesis of the two different pathways ; de novo carcinoma or adenoma-carcinoma sequence.
It is suggested from our data (Table) that de novo carcinoma of the gallbladder, regardless of intramucosal size and depth of invasion, develops by p53 alteration at 60-70%, and that K-ras mutation does not play an important role in the development of de novo cancer because of as low as 10% incidence, and that apc mutation has no relation to the cancer-development.
On the contrary, carcinoma arising from adenoma and also adenoma did not indicate p53 abnormalities as well as apc and K-ras mutation.
This is the first report to indicate that genetic alteration in gallbladder carcinogenesis is different between de novo carcinoma and carcinoma arising from adenoma.
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