| Project/Area Number |
06042009
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMASHITA Shunichi Nagasaki University, School of Medicine, Professor, 医学部, 教授 (30200679)
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| Co-Investigator(Kenkyū-buntansha) |
FOFANOVA Olga Moscow Endocrinology Research Center, 小児科, 医長
ASHTAKHOVA Larisa Minsk Radiation Research Center, 甲状腺部門, 教授
DIMETCHIK Eugen Minsk Thyroid Oncology Center, 内分泌外科, 教授
SHIBATA Yoshisada Radiation Effects Research Center, Nagasaki, 疫学生物統計部, 部長
HOSHI Masaharu Hiroshima University Radiation Research Cneter, 医学部, 教授 (50099090)
NAMBA Hiroyuki Nagasaki University, School of Medicine, 医学部, 助教授 (80237635)
ITO Masahiro Nagasaki University, School of Medicine, 医学部, 助教授 (30184691)
KOTOVA AL ゴメリ診断センター, 細胞診病理部門, 部長
ASHATAKNOVA エルエヌ ミンクス放射線医学研究所, 甲状腺部門, 教授
DEMETCHIK EP ミンスクがんセンター, 内分泌外科, 教授
ASHTAKNOVA L ミンスク放射線医学研究所, 甲状腺部門, 教授
DEMETCHIK E. ミンスクがんセンター, 内分泌外科, 教授
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥17,200,000 (Direct Cost: ¥17,200,000)
Fiscal Year 1996: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1995: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1994: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Chernobyl / Childhood Thyroid Cancer / Epidemiology / Belarus / Gene analysis / Radiation |
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| Research Abstract |
Thyroid cancer was the first solid tumor that demonstrated an increased incidence among the Japanese atomic bomb survivors. In recent studies conducted around the Chernobyl, an increasing incidence of childhood thyroid cancer has been reported. However, no studies have yet been able to answer the question on the casual relationship between the precise radiation exposure by the Chernobyl accident and the thyroid diseases. We, therefore, started to establish the data-collecting system and obtain the data from accurate and unbiased radiation-related childhood thyroid screening studies.
Despite the difficult situation of Belarus, we have clarified the clinical and histological characteristics of childhood thyroid cancer on a basis of good relationship with the Belarussian Ministry of Hhealth and related Institutes. The establishment of fine-needle aspiration biopsy and cytological diagnosis revealed the malignant potential of thyroid nodules detected around Chernobyl. The role of p53 and TSH receptor has been investigated using a molecular biology method with a couple of new findings. The further study is, however, needed to clarify the direct evidence of radiation-induced thyroid diseases and the molecular mechanism of thyroid tumorigenesis.
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