| Project/Area Number |
06042014
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Nagoya City University Medical School |
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Principal Investigator |
TOKUDOME Shinkan Department of Public Health, Nagoya City Univ., Medical School, Professor, 医学部, 教授 (00037441)
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| Co-Investigator(Kenkyū-buntansha) |
陳 公超 海門市衛生防疫局, 局長
陳 剛 上海医科大学, 公衆衛生学院, 講師
兪 順章 上海医科大学, 予防医学研究所, 教授
OHNO Tomoyoshi Department of Public Health Nagoya City University, Medical School, 医学部, 助手 (90264712)
MIZOKAMI Masashi Department of Second Internal Medicine Nagoya City University, Medical School, 医学部, 助手 (40166038)
SUEOKA Eizaburo Department of Serology and Virology, Research Institute, Saitama Cancer Center, 研究員 (00270603)
ODA Hideaki Department of Pathology, Faculty of Medicine, University of Tokyo, 医学部, 助教授 (40214142)
TASHIRO Fumio Department of Biological Science and Technology, Faculty of Engineering, Science, 基礎工学部, 教授 (70089332)
UENO Yoshio Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Scie, 薬学部, 教授 (00084418)
HARADA Ken-ichi Dept.of Instrumental Analytical Chemistry, Faculty of Pharmacy, Meijo University, 薬学部, 助教授 (90103267)
CHEN Gong-chao Haimen City Health and Anti-Epidemic Station Jiang-Su Province
CHEN Gang Department of Epidemiology, School of Public Health, Shanghai Medical University
YU Shun-zhang Institute of Preventive Medicine Shanghai Medical University
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 1995: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1994: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | Haimen, China / Hepatocellular carcinoma / Host factors / Environmental factors / Hepatitis B virus / Mycotoxins / Microcystins / Epidemiology / HCV / AFB_1 |
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| Research Abstract |
In order to prevent hepatocellular carcinoma (HCC) in Haimen, China, where the incidence of HCC is the highest in the world, an international multidisciplinary research is now underway sponsored by the Mombusho International Scientific Research Project, Special Cancer Research during 1995-1996.
Microcystins, toxins produced by the algae in the creek, river and pond water and recently alleged to be promoters of hepatocarcinogenesis, were detected in the drinking water.
Mycotoxins, such as aflatoxin B_1 and fumonisins, were detected in staple food, such as peanuts and corns.
So far, 134 pairs of cases and controls were collected. Past history and family history of chronic hepatic diseases in cases were more frequent than controls. HCCs in Haimen were mainly associated with hepatitis B virus (HBV) but not hepatitis C virus. Both vertical infection and horizontal transmission of HBV may be responsible for the onset of HCCs. Neither smoking nor alcohol drinking were related to the onset of HCCs. Genetic polymorphisms of ALDH2 and CYP2E1 were not associated with HCCs. The activity of TNFalpha in cases was highter than controls.
HCCs in Haimen were not necessarily related to liver cirrhosis or fibrosis. Aflatoxin B_1-associated specific mutations in p53 were observed.
To prevent HCCs in Haimen, prevention of HBV infection seems most important and reduced intake of mycotoxin-polluted food are advised. In this study, a possible association between drinking water or microcystins and HCCs were not detected in this study.
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