| Co-Investigator(Kenkyū-buntansha) |
辛 祐源 東亜大学校, 医科大学, 助教授
李 孝錫 ソウル大学, 医科大学, 助教授
辛 海林 東亜大学校, 医科大学, 助教授
金 丁竜 ソウル大学, 医科大学, 教授
安 允玉 ソウル大学, 医科大学, 教授
KAMIMURA Seiichiro Dept of Internal Med, School of Medicine, Fukuoka University, Assistant Professo, 病院, 講師 (20258544)
WATANABE Hiroshi Dept of Internal Med, School of Medicine Osaka University, Assistant Professor, 医学部, 講師 (40220917)
HAYASHI Norio Dept of Internal Med, School of Medicine Osaka University, Assistant Professor, 医学部, 講師 (00144478)
YAMANO Hajime Dept of Reagent Production & Development, Osaka Red Cross Blood Cancer, Director, 部長
OKUBO Yasuto Osaka Red Cross Blood Cancer, President, 所長
HEN Hidetoshi Kyouwa Hospital, President, 院長
TANAKA Hideo Dept of Epidemiology, Osaka Medical Center for Cancer and Cardiovasclar Diseases, 調査部, 係長
TSUKUMA Hideaki Dept of Epidemiology, Osaka Medical Center for Cancer and Cardiovasclar Diseases, 調査部, 課長
KONO Suminori Dept of public Health, School of Medicine, Kyusyu University, Professor, 医学部, 教授 (70128015)
UNE Hiroshi Dept of Hygiene, School of Medicine, Fukuoka University, Professor, 医学部, 教授 (40122676)
AHN Yoon-Ok Dept of Preventive Med, College Medicine, Seoul National University, Professor
LEE Hyo-Suk Dept of Internal Med, College of Medicine, Seoul National University, Associate
SHIN Hai-Rim Dept of Preventive Med, College Medicine, Dong-A University, Associate Professor
SHIN Woo-Won Dept of Internal Med, College of Medicine, Dong-A University, Associate Professo
KIM Chung-Yong Dept of Internal Med, College of Medicine, Seoul National University, Professor
田中 秀夫 大阪府立成人病センター, 調査部, 係長
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 1996: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1995: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1994: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Research Abstract |
In order to clarify the reasons why Koreans in Japan demonstrate a high risk for developing liver cancer, we have been carrying out epidemiological studies, while focusing on the distribution of hepatitis C virus (HCV) genotypes and cytochrome P-450 2E1 (CYP2E1) genotypes, and the relationships between the development of hepatocellular carcinoma (HCC) and the genotypes to HCV and CYP2E1 among 3 groups ; Koreans in Korea, Koreans in Japan and Japanese in this 3-year Korea-Japan Joint Study.
HCV genotype 3 was found to be prevalent among HCC patients and blood donors of Koreans in Korea. On the other hand, HCV genotype 2 was prevalent among both HCC patients and blood donors of both Japanese and Koreans in Japan. Koreans in Japan thus demonstrated a similar distribution of HCV genotypes to that lof Japanese.
We next conducted a case-control study on the association between the development of HCC and HCV genotypes at the Osaka Medical Center for Cancer and Cardiovascular Diseases, and Osaka University. As a result, HCV genotype 2 was found to show a higher risk for the development of liver cirrhosis and HCC than HCV genotypes 3 and 4.
CYP2E1 is the only enzyme that metabolizes N-nitrosodimethylamine, a potent hepatocarcinogen. CYP2E1 genotype is related to individual susceptibility to diethlnitrosamine-induced liver cancer, and this susceptibility was observed to be accelerated by long-term administration of ethanol.
No difference was observed in the distribution of CYP2E1 genotypes between HCC Koreans and Japanese patients. CYP2E1 genotype c1/c2 and c1/c2 showed a somewhat higher risk for the development of HCC than CYP2E1 genotype c1/c1, but the difference was not statistically significant.
In conclusion, HCV genotype 2 was prevalent among Koreans in Japan, which may thus play a role in their increased risk for developing HCC.
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