| Project/Area Number |
06042020
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | National Cancer Center Research Institute, East |
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Principal Investigator |
TSUGANE Shoichiro National Cancer Center Research Institute, East Epidemiology and Biostatistics Division Director, 支所臨床疫学研究部, 部長 (40179982)
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| Co-Investigator(Kenkyū-buntansha) |
BRENTANI Ricardo University of Sao Paulo, Brazil, 医学部, 教授
HAMADA Gerson University of Sao Paulo, Brazil, 公衆衛生学部疫学教室, 助教授
LAURENTI Ruy University of Sao Paulo, Brazil, 公衆衛生学部疫学教室, 教授
WAKABAYASHI Kenji Biochemistry Division, 生化学部, 部長 (60158582)
KOWALSKI Lui A. C. Camargo病院, 部長
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥10,900,000 (Direct Cost: ¥10,900,000)
Fiscal Year 1995: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1994: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | Japanese immigrants / Brazil / Carcinogenic factors / Dietary Habitactor / Biological markers / Cross-sectional study / Case-control study / Stomach cancer / Genetic factors |
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| Research Abstract |
Epidemiological studies on diet and cancer have been conducted in Brazil, a multi-ethnic nation with 1.2 million residents of Japanese ancestry.A dietary record survey was applied to randomly selected Japanese Brazilians in Sao Paulo and a 3 day dietary record obtained from 191 subjects.Nutritional caluculation is on-going for these data.A cross-sectional study of dietary habits was conducted in 111 randomly selected Japanese Peruvians in Lima and food frequency data and blood samples obtained from them.
A case-control study of lung cancer in Brazil suggested that the risk of cigarette smoking interacted with the exon 7 polymorphism of CYP1A1.A case-control study of stomach cancer has also been done in Brazil.Questionnaire data blood components were collected from 101 Japanese (63 males and 38 females) and 248 non-Japanese (179 males and 69 females) cases of gastric cancer and their controls in the Sao Paulo area.The blood samples were used for laboratory assays such as pepsinogen measurement, Helicobactor pylori antibody analysis and DNA extraction for genotyping.Life-time cigarette consumption over 50 pack-years was significantly associated with increased risk of stomach cancer for non-Japanese Brazilians (OR=1.8 compared with never smoking), but not for Japanese Brazilians.Frequent consumption of fried food was associated with increased risk in both groups, while daily beef consumption increased the risk only in Japanese Brazilians (OR=3.7 compared with monthly consumption).In adittion, frequent fruit and vegetable intake was associated with reduced risk of stomach cancer and this association was remarkable in non-Japanese Brazilians who consumed less fruit and vegetables than Japanese Brazilians.These findings suggest that the risk factors vary among ethnic groups and may be related to genetic background and/or exposure levels of environmental factors.
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