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Epidemiological Study on Diet and Cancer among Japanese Brazilian

Research Project

Project/Area Number 06042020
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionNational Cancer Center Research Institute, East

Principal Investigator

TSUGANE Shoichiro  National Cancer Center Research Institute, East Epidemiology and Biostatistics Division Director, 支所臨床疫学研究部, 部長 (40179982)

Co-Investigator(Kenkyū-buntansha) BRENTANI Ricardo  University of Sao Paulo, Brazil, 医学部, 教授
HAMADA Gerson  University of Sao Paulo, Brazil, 公衆衛生学部疫学教室, 助教授
LAURENTI Ruy  University of Sao Paulo, Brazil, 公衆衛生学部疫学教室, 教授
WAKABAYASHI Kenji  Biochemistry Division, 生化学部, 部長 (60158582)
KOWALSKI Lui  A. C. Camargo病院, 部長
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥10,900,000 (Direct Cost: ¥10,900,000)
Fiscal Year 1995: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1994: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsJapanese immigrants / Brazil / Carcinogenic factors / Dietary Habitactor / Biological markers / Cross-sectional study / Case-control study / Stomach cancer / Genetic factors
Research Abstract

Epidemiological studies on diet and cancer have been conducted in Brazil, a multi-ethnic nation with 1.2 million residents of Japanese ancestry.A dietary record survey was applied to randomly selected Japanese Brazilians in Sao Paulo and a 3 day dietary record obtained from 191 subjects.Nutritional caluculation is on-going for these data.A cross-sectional study of dietary habits was conducted in 111 randomly selected Japanese Peruvians in Lima and food frequency data and blood samples obtained from them.
A case-control study of lung cancer in Brazil suggested that the risk of cigarette smoking interacted with the exon 7 polymorphism of CYP1A1.A case-control study of stomach cancer has also been done in Brazil.Questionnaire data blood components were collected from 101 Japanese (63 males and 38 females) and 248 non-Japanese (179 males and 69 females) cases of gastric cancer and their controls in the Sao Paulo area.The blood samples were used for laboratory assays such as pepsinogen measurement, Helicobactor pylori antibody analysis and DNA extraction for genotyping.Life-time cigarette consumption over 50 pack-years was significantly associated with increased risk of stomach cancer for non-Japanese Brazilians (OR=1.8 compared with never smoking), but not for Japanese Brazilians.Frequent consumption of fried food was associated with increased risk in both groups, while daily beef consumption increased the risk only in Japanese Brazilians (OR=3.7 compared with monthly consumption).In adittion, frequent fruit and vegetable intake was associated with reduced risk of stomach cancer and this association was remarkable in non-Japanese Brazilians who consumed less fruit and vegetables than Japanese Brazilians.These findings suggest that the risk factors vary among ethnic groups and may be related to genetic background and/or exposure levels of environmental factors.

Report

(2 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Hamada,G.S.,et al.: "The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1),rather than RsaI polymorphism of IIE1 (CypIIE1),is associated with lung cancer in Rio de Janeiro." Cancer Epidemiolgr Biomarkers & Prevention. 4. 63-67 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugimura,H.,et al.: "CYP1A1 and CYP2E1 polymorphism and lung cancer,case-control study in Rio de Janeiro." Pharmacogenetics. 5. S145-S148 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsugane,S.,et al.: "The second Brazil-Japan Cancer Meeting." Acta Oncologica Brasileira. 15. 61-66 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsugane,S.,et al.: "Lifestyle and health related factors among randomly selected Japanese residents in the city of Sao Paulo,Brazil,and their comparisons with Japanese in Japan" Journal of Epidemiology. 4. 37-46 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Karita,K.,et al.: "Serum selenium levels in middle-aged Japanese men in Sao Paulo,Brazil and in five areas in Japan." Biomedical Research on Trace Elements. 5. 77-84 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suzuki,I.,et al.: "Risk factors for lung cancer in Rio de Janeiro : a case-control study." Lung Cancer. 11. 179-190 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugimura,H.,et al.: "Cytochrome P450 IA1 genotype in lung cancer patients and controls in Rio de Janeiro,Brazil" Cancer Epidemiolgr Biomarkers & Prevention. 3. 145-148 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugimura H., et al.: "Cytochrome P450 IA1 genotype in lung cancer patients and controls in Rio de Janeiro, Brazil" Cancer Epidemiology Biomarkers & Prevention. 3. 145-148 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suzuki I., et al.: "Risk factors for lung cancer in Rio de Janeiro : a case-control study" Lung Cancer. 11. 179-190 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Karita K., et al.: "Serum selenium levels in middle-aged Japanese men in Sao Paulo, Brazil and in five areas in Japan" Biomedical Research on Trace Elements. 5. 77-84 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsugane S., et al.: "Lifestyle and health related factors among randomly selected Japanese residents in the city of Sao Paulo, Brazil, and their comparisons with Japanese in Japan" Journal of Epidemiology. 4. 37-46 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsugane S., et al.: "The second Brazil-Japan Cancer Meeting" Acta Oncologica Brasileira. 15. 61-66 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugimura H., et al.: "CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro" Pharmacogenetics. 5. S145-S148 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hamada GS., et al.: "The heme-binding region polymorphism of cytochrome P450IA1(CypIA1), rather than RsaI polymorphism of IIE1(CypIIE1), is associated with lung cancer in Rio de Janeiro" Cancer Epidemiology Biomarkers & Prevention. 4. 63-67 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsugane,S.,et al.: "Lifestyle and health related factors among randomly selected Japanese residents in the city of Sao Paulo,Brazil,and their comparisons with Japanese in Japan" Journal of Epidemiology. 4. 37-46 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Karita,K.,et al.: "Serum selenium levels in middle-aged Japanese men in Sao Paulo,Brazil and in five areas in Japan." Biomedical Research on Trace Elements. 5. 77-84 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,I.,et al.: "Risk factors for lung cancer in Rio de Janeiro:a case-control study." Lung Cancer. 11. 179-190 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugimura,H.,et al.: "Cytochrome P450 IAI genotype in lung cancer patients and controls in Rio de Janeiro,Brazil" Cancer Epidemiolgr Biomarkers & Prevention. 3. 145-148 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hamada,G.S.,et al.: "The heme-binding region polymorphism of cytochrome P450IA1(CypIA1),rather than RsaI polymorphism of IIEl(CypIE1),is associated with lung cancer in Rio de Janeiro." Cancer Epidemiolgr Biomarkers & Prevention. 4. 63-67 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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