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General Studies on Special Cancer Research

Research Project

Project/Area Number 06042021
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

TOMINAGA Suketami  Aichi Cancer Center Research Institute, 所長 (30124530)

Co-Investigator(Kenkyū-buntansha) FUJIYAMA Chihaya  Kagoshima University School of Medicine, 医学部・公衆衛生学教室, 助手 (30274814)
IKEDA Noriaki  Department of Oral & Maxillofacial Surg. (II), Aichigakuin University, 歯学部・口腔外科学第2講座, 講師 (30150791)
SASAKI Ryuichiro  Department of Public Health, Aichi Medical University, 公衆衛生学教室, 教授 (80131241)
ICHIHASHI Masamitsu  Kobe University School of Medicine, 医学部・皮膚科学講座, 教授 (00030867)
SHIMIZU Hiroyuki  Department of Public Health, Gifu University School of Medicine, 医学部・公衆衛生学教室, 教授 (90073139)
TAJIMA Kazuo  Division of Epidemiology, Aichi Cancer Center Research Institute, 疫学部, 部長 (30150212)
YOSHIMURA Takesumi  Institute of Industrial Ecological Sciences University of Occupational and Envir, 産業生態科学研究所, 教授 (20037435)
OHNO Yoshiyuki  Department of Preventive Medicine, Nagoya University School of Medicine, 医学部・予防医学教室, 教授 (10160590)
FUJIKI Hirota  Saitama Cancer Center Research Institute, 所長 (60124426)
HIROHASHI Setsuo  National Cancer Center Research Institute, 副所長 (70129625)
YOSHIDA Mitsuaki  Institute of Medical Science, University of Tokyo, 医科学研究所, 所長 (80012607)
YAMAMOTO Tadashi  Institute of Medical Science, University of Tokyo, 制癌研究部, 教授 (40134621)
KUROKI Toshio  Institute of Molecular Oncology, Showa University, 腫瘍分子生物学研究所, 所長 (90006073)
KITAGAWA Tomoyuki  The Cancer Institute, 所長 (50085619)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 1996: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1995: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1994: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsCancer / Stomach cancer / Esophageal cancer / Liver cancer / Skin cancer / China / South-East Asia / Central-South America / 大腸がん / EBウイルス / フランス / ギリシャ / 口腔がん / マレーシア / インドネシア / 肺がん / ホンコン
Research Abstract

This study group has been functionning as a planning and coordinating group of all the Special Cancer Research. The major activities of this study group is as follows :
1) To conduct pilot studies on cancer research in both developed and developing countries and to evaluate the feasibility and prospects of future studies on cancer. In fiscal years 1994-1996,5 pilot sutdies have been conducted ;
(1) Comparative epidemiology on stomach and esophageal cancers in China.
(2) Epidemiological study on nutrition and oral cancer in Malaysia.
(3) Study on risk factors of skin cancer in Indonesia.
(4) Epidemiological study on EB virus infection an stomach cancer in Hong Kong, Thailand and Malaysia.
(5) Epidemiological study on nutrition (especially, fat intake) and cancer in Mediterranean countries (Greece and France).
All of the 5 pilot studies were regarded as feasible and fruitful and (1) and (2) were graded up to regular planned studies. (3) is expected to be feasible and will be graded up to a planned regular study nexy year. (4) and (5) were regarded as feasible, but more information and preparations were needed to be graded up to regular planned studies. Thus, the two pilot studies will be continued in the next year.
2) To select and propose priority planned studies on cancer considering the results of pilot studies. In fiscal year 1994-1996,15 planned studies were were selected and proposed.
3) To hold meetings of chief investigators to review progress of each study and to discuss problems in conducting international collaborative studies.
The meeting was held once a year in the end of fiscal year (middle of March).
4) To hold a symposium to report major results of the selected topics once a year in conjunction with the meeting of chief investigators.
5) To distribute information on special cancer research through news letters to all related investigators. The news letter was published three times a year.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (234 results)

All Other

All Publications (234 results)

  • [Publications] 富永祐民: "日本の癌,世界の癌-最近の動向" 癌と化学療法. 22. 1-8 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kawabuchi,B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse strain conaining an albumin promoter-fused simian virus 40 large T angigen gene." Jpn.J.Cancer Res.85. 601-609 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamamoto,N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyasaka,K.: "Frequent loss of haterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikuta,T.: "Cholesterol sulfate,a novel activator for the η isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroki,T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.J.Cancer Res.85. 1320-1321 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Umemori,H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujimoto,J.: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki,T.: "Tax protein of HTLV-1 interacts with the Re1 homology domain of NF-κB p65 and c-Re1 proteins bound to the NF-κB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirai,H.: "Tax pretein of human T-cell leukemia virus type 1 binds to the ankyrin motifs of inhibitory factor κB and induces nuclear translocation of transcription factor NF-κB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa,Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kihana,T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsuda,H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extend of spread." Cancer Res.54. 513-517 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsuda,H.: "Association among p53 gene mutation,nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki,H.: "Tumor necrosis factor-α,a new tumor promoter,enegendered bybiochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki,H.: "A new tumor promotion pathway and its inhibitors." Cencer Detection and Prevention. 18. 1-7 (1994)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohta,T.: "Nodularin,a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tamakoshi,A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wakai,K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉村健清: "もう1つの大久野島-旧毒ガス弾製造工場従事者の慢性気管支炎有病率-" 医学のあゆみ. 170. 950-951 (1994)

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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Washio,M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka,Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Zaninovic,V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia" AIDS Res Human Reroviruses. 10. 97-101 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 柳生聖子: "女性における血清βカロチン値の変動に関する縦断的研究" 医学と生物学. 129. 29-33 (1994)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] 伊藤宜則: "南北海道住民における血清カロチノイド、レチノール及びα-トコフェロール値と血清過酸化脂質値との関連性" ビタミン. 68. 351-363 (1994)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga,S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyasaka,K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki,T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Chida,K.: "Cholesterol sulfate,a second messenger for the η isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koike,M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki,T.: "Tax protein of HTLV-1 destabilizes the complexs of NF-κB and 1κB-α and induces nuclear translocation NF-κB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa,Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood.85. 1865-1870 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kanai,Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)

    • Description
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      1996 Final Research Report Summary
  • [Publications] Shimoyama,Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshimura,K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Rroc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sueoka,E.: "Activation of protein kinase C by mycobacterian cord necrosis factor-α release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suganuma,M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno,Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia.4. 131-134 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Budiningsih,S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa,Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saku,M.: "Mortality in psychiatric patients,with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogura,C.: "Prevalence of senile dementia in Okinawa,Japan." International Journal of Epidemiology. 24. 373-380 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takezaki,T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue,M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue,M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex,age,and season." J.Clin.Epidemiol.50. 69-77 (1997)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koo,L.C.: "Dietary and lifestyle correlates of passive smoking in Hong Kong,Japan,Sweden,and USA." Social Science and Medicine. in press (1997)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsunashima,K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koyama,Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human α-fetoprotein isoforms produced in transgenic mice." Biocehmical and Biiophysical Research Communications. 223. 757-761 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishida,T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroki,T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koike,M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes,but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Jia,L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.in press (1997)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Murakami,A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest.Dermatol.106. 790-794 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujimoto,J.: "Characterization of the transforming activity of p80,a hyperphosphorylated protein in a ki-1 lymphoma cell line with t (2;5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwahara,T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tezuka,T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase,p53/56 lyn,in the B cell antigen recoptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)

    • Description
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      1996 Final Research Report Summary
  • [Publications] Yoshida,M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<INK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)

    • Description
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      1996 Final Research Report Summary
  • [Publications] Baffa,R.: "Loss of heterozygosity for chromosome II in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ochiai,A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Taylor,C.: "Inhibition of Protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Quinn,R.J.: "Inhibition of Protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Priharutono,J.: "Breast cancer case control study : conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)

    • Description
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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki,S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal of Indonesia. 4. 169-176 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wakai,K.: "A case-control study of breast cancer among Japanese women in Tokyo" Medical Journal of Indonesia. 4. 177-182 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 徳井 教孝: "萎縮性胃炎とHelicobacter pylori感染の血清疫学研究" 産業医科大学雑誌. 18. 133-140 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西阪 眞一: "地域住民における健康度自己評価とその後の死亡 -7年間の追跡研究-" 作業医科大学雑誌. 18. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Utoguchi,K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). 119-131 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima,K.: "Research activities of epidemiology in Japan : Infectious disease,epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima,K.: "Ethnoepidemiology,a new paradigm,for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima,K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu,H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hu,Y.H.: "Association of body mass index,physical activity and reproductive histories with breast cancer : A case control study in Gifu,Japan." Breast Cancer Research and Treatment. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagata,C.: "Choice of response scale for health measurement : Comparison of 4,5,and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-1297 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroishi,T.: "Gann Monograph on Cancer Research No.41 : Cancer Mortality and Morbidity Statistics" Japan Scientific Societies Press,Tokyo,(1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga,S.: "Cancer Surveys Vol.19/20 : Trends in Cancer Incidence and Mortality" Cold Spring Harbor Laboratory Press, 583 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga,S.: "Can they be controlled? In Proceedings of the International Cancer Congress. Plenary and Special Lectures" Monduzzi Editore,Bologna, (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno,Y.: "Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH" Adenine Press, (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima,K.: "Adult T-cell leukemia" Oxford Univ.Press, 230 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki,H.: "Toxic Microcystits" CRC Press, 203-212 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kawabuch, B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse n strain conaining an albumin promoter-fused simian virus 40 large T angige gene." Jpn.J.Cancer Res.85. 601-609 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamamoto, N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4- dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine- induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikuta, T.: "Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroki, T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.j.Cancer Res.85. 1320-1321 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujimoto, J.: "brt, a mouse gene encoding a novel recepter-type protein-tyrosine kinase, is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki, T.: "Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappaB P65 and c-Rel Proteins bound to the NF-kappaB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirai, H.: "Tax pretein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappaB and induces nuclear translocation of transcription factor NF-kappaB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa, Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kihana, T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsuda, H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread." Cancer Res.54. 513-517 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsuda, H.: "Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki, H.: "Tumor necrosis factor-alpha, a new tumor promoter, enegendered by biochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki, H.: "A new tumor promotion pathway and its inhibitors." Cancer Detection and prevention. 18. 1-7 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohta, T.: "Nobdlarin, a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tamakoshi, A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wakai, K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Washio, M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka, Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
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      1996 Final Research Report Summary
  • [Publications] Zaninovic, V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia." AIDS Res Human Reroviruses. 10. 97-101 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga, S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki, T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Chida, K.: "Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koike M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki, T.: "Tax protein of HTLV-1 destabilizes the complex of NF-kappaB and I kappaB-alpha and induces nuclear translocation NF-kappaB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa, Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood. 85. 1865-1870 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kanai, Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimoyama, Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshimura, K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Proc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sueoka, E.: "Activation of protein kinase C by mycobacterial cord necrosis factor-alpha release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suganuma, M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno, Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia. 4. 131-134 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Budiningsih, S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa, Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saku, M: "Mortality in psychiatric patients, with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogura, C.: "Prevalence of senile dementia in Okinawa, Japan." International Journal of Epidemiology. 24. 373-380 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takezaki, T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1996 Final Research Report Summary
  • [Publications] Inoue, M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue, M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex, age, and season." J.Clin.Epidemiol.50. 69-77 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koo, L,C.: "Dietary and lifestyle correlates of passive smoking in Hong kong, Japan, Sweden, and USA." Social Science and Medicine. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsunashima, K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koyama, Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human alpha-fetoprotein isoforms produced in transgenic mice." Biocemical and Biophysical Research Communications. 223. 757-761 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishida, T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroki, T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koike, M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes, but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Jia, L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Murakami, A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest, Dermatol.106. 790-794 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fijimoto, J.: "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with (2 ; 5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwahara, T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tezuka, T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase, p53/561yn, in the B cell antigen receptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1996 Final Research Report Summary
  • [Publications] Yoshida, M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki, T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<1NK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Baffa, R.: "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ochiai, A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Teylor, C.: "Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Quinn, R.J.: "Inhibition of protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Priharutono, J.: "Breast cancer case control study ; conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Suzuki, S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal Indonesia. 4. 169-176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Wakai, K.: "A case-control study of breast cancer among Japanese women in Tokyo." Medical Journal of Indonesia. 4. 177-182 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Utoguchi, K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima, K: "Research activities of epidemiology in Japan : Infectious disease, epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima, K.: "Ethnoepidemiology, a new paradigm, for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima, K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hu, Y.H.: "Association of body mass index, physical activity and reproductive histories with breast cancer : A case control study in Gifu, Japan." Breast Cancer Research and Treatment. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagata, C.: "Choice of response scale for health measurement : Comparison of 4,5. and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-197 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroishi, T.et al.: Japan Scientific Societies Press, Tokyo. Gann Monograph on Cancer Research No.41 : Cancer Mortality and Morbidity Statistics, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga, S.et al.: Cold Spring Harbor Laboratory Press. Cancer Surveys Vol.19/20 : Trends in Cancer Incidence and Mortality, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tominaga, S.et al.: Monduzzi Editore, Bologna. Can they be controlled? In Proceedings of the International Cancer Congress. Plenary and Special Lectures, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohno, Y.et al.: Adenine Press. Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tajima, K.et al.: Oxford Univ.Press. Adult T-cell leukemia, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fujiki, K.: CRC Press. Toxic Microcystis, 203-232 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue,M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66 ・3. 309-314 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Inoue,M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex,age,and season." J.Clin.Epidemiol.50・1. 69-77 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koo,L.C.: "Dietary and lifestyle correlates of passive smoking in Hong kong,Japan,Sweden,and USA." Social Science and Medicine. in press (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsunashima,K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koyama,Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human α-fetoprotein isoforms produced in transgenic mice." Biocehmical and Biiophysical Research Communications. 223. 757-761 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ishida,T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kuroki,T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koike,M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes,but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Jia,L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Murakami,A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest.Dermatol.106. 790-794 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujimoto,J.: "Characterization of the transforming activity of p80,a hyperphosphorylated protein in a Ki-1 lymphoma cell line with t (2;5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwahara,T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tezuka,T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase,p53/56 lyn,in the B cell antigen recoptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshida,M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7・5. 349-360 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<INK4A> and counteracts its inhibitory activity towards CDK4." The ENBO J.15・7. 1607-1614 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Baffa,R.: "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer Research. 56・2. 268-272 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ochiai,A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69・1. 28-33 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Taylor,C.: "Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Quinn,R.J.: "Inhibition of protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Priharutono,J.: "Breast cancer case control study : conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4・3. 143-147 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Suzuki,S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal of Indonesia. 4・3. 169-176 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Wakai,K.: "A case-control study of breast cancer among Japanese women in Tokyo." Medical Journal of Indonesia. 4・3. 177-182 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 徳井教孝: "萎縮性胃炎とHelicobacter pylori感染の血清疫学研究" 産業医科大学雑誌. 18・2. 133-140 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 西阪眞一: "地域住民における健康度自己評価とその後の死亡-7年間の追跡研究-" 産業医科大学雑誌. 18・2. 119-131 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Utoguchi,K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tajima,K.: "Research activities of epidemiology in Japan : Infectious disease,epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tajima,K.: "Ethnoepidemiology,a new paradigm,for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tajima,K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu,H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hu,Y.H.: "Association of body mass index,physical activity and reproductive histories with breast cancer : A case control study in Gifu,Japan." Breast Cancer Research and Treatment. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nagata,C.: "Choice of response scale for health measurement : Comparison of 4,5,and 7-point scales and visual analog scale." Journal of Epidemiology. 6・4. 192-197 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujiki,H.: "Toxic Microcystits" CRC Press, 203-232 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tominaga,S.et al.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Miyasaka,K.et al.: "Frequent loss of heterozygosity on chromosome 4 in dietyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suzuki,T.et al.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Prince Masahito et al.: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Chida,K.et al.: "Cholesterol sulfate,a second messenger for the η isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koike M.et al.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suzuki,T.et al.: "Tax protein of HTLV-1 destabilizes the complexs of NF-κ B and IκB-α and induces nuclear translocation NF-κB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Furukawa,Y.et al.: "HTLV-1 Tax expressed at the same level infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood.85. 1865-1870 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kanai,Y.et al.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochm.Biophys.Res.Commun.208. 1067-1072 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shimoyama,Y.et al.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshimura,K.et al.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Proc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sueoka,E.,et.al.: "Activation of protein kinase C by mycobacterial cord necrosis factor-α release in mouse lung tissues.mor" Jpn. J. Cancer Res.86. 746-755 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suganuma,M.et al.: "Tautomycin:an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular atomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohno,Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia. 4. 131-134 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Budiningsih,S et al.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohno Y.et al.: "Tea consumption and lung cancer risk:A case-control study in Okinawa,Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Saku,M.et al.: "Mortality in psychiatric patients,with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogura,C.et al.: "Prevalence of senile dementia in Okinawa,Japan." International Journal of Epidemiology. 24. 373-380 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takezaki,T.et al.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 富永祐民: "日本の癌,世界の癌-最近の動向" 癌と化学療法. 22. 1-8 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawabuchi,B.et al.: "Subcu taneous sarcomas of probable neuronal origin in a transgenic mouse strain conaining an albumin promoter-fused simian virus 40 large T angigen gene." Jpn.J.Cancer Res.85. 601-609 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamamoto,N.et al.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Miyasaka,K.et al.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikuta,T.et al.: "Cholesterol sulfate,a novel activator for the η isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kuroki,T.: "Evaluation of carcinogenic risks to humans:A list of the IARC." Jpn.J.Cancer Res.85. 1320-1321 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Umemori,H.et al.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fujimoto,J.et al.: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,T.et al.: "Tax protein of HTLV-1 interacts with the Rel homology domain of NF-κ B p65 and c-Rel proteins bound to the NF-κ B binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirai,H.et al.: "Tax pretein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor κ B and induces nuclear translocati on of transcription factor NF-κ B proteins for transcriptional activat ion." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Furukawa,Y.et al.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Cancer Res.(in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Kihana,T.et al.: "Pregnostic significance of the overexpression of cerbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsuda,H.et al.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread." Cancer Res.54. 513-517 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsuda,H.et al.: "Association among p53 gene mutation,nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fujiki,H.et al.: "Tumor necrosis factor-α,a new tumor promoter, enegendered bybiochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fujiki,H.et al.: "A new tumor promotion pathway and its inhibitors." Cancer Detection and Prevention. 18. 1-7 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta,T.et al.: "Nodularin,a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tamakoshi,A.et al.: "Serum cholesterol and cancer mortality in Japanese civil service workers:Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Wakai,K.et al.: "Risk factors for breast cancer among Japanese women in Tokyo:A case-control study." J.Epidemiol.4. 65-71 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 吉村健清,他: "もう1つの大久野島-旧毒ガス弾製造工場従事者の慢性気管支炎有病率-" 医学のあゆみ. 170. 950-951 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Washio,M.et al.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka, Japan:A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Zaninovic,V.et al.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia" AIDS Res Human Reroviruses. 10. 97-101 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 柳生聖子,他: "女性における血清βカロチン値の変動に関する縦断的研究" 医学と生物学. 129. 29-33 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 伊藤宜則,他: "南北海道住民における血清カロチノイド、レチノール及びα-トコフェロール値と血清過酸化脂質値との関連性" ビタミン. 68. 351-363 (1994)

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      1994 Annual Research Report
  • [Publications] Tominaga,S.et al.: "Can they be controlled? In Proceedings of the International Cancer Congress.Plenary and Special Lectures" Monduzzi Editore,Bologna, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tominaga,S.et al.: "Cancer Surveys 19/20:Trends in Cancer Incidence and Mortality" Cold Spring Harbor Laboratory Press, 583 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohno,Y.et al.: "Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH" Adenine Press, (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tajima,K.et al.: "Adult T-cell leukemia" Oxford Univ.Press, 230 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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