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Mechanism of accumulation of mitochondrial DNA mutations associated with aging and diseases

Research Project

Project/Area Number 06044103
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionNagoya University

Principal Investigator

OZAWA Takayuki  Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya professor, 医学部, 教授 (80022771)

小沢 高将 (1995)  名古屋大学, 医学部, 教授

Co-Investigator(Kenkyū-buntansha) NAGLEY Phillip  Department of Biochemistry, Monash University professor, 医学部, 教授
LINNANE W.An  モナッシュ大学, 理学部, 教授
HAYAKAWA Mika  Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya Le, 医学部, 講師 (10238090)
TANAKA Masashi  Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya As, 医学部, 助教授 (60155166)
LINNANE Anthony w.  Center for Molecular Biology and Medicine, Monash University professor
PHILLIP Nagl  モナッシュ大学, 医学部, 教授
ANTHONY Linn  モナッシュ大学, 理学部, 教授
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1995: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1994: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsmitochondrial DNA / electron transfer defects / mitochondrial myopathy / mutation / reactive oxygen species / deletion / aging / degenerative diseases / 電子伝達系酵素欠損 / 活性酸素ラジカル / 加齢現象 / 慢性疲労症候群
Research Abstract

To understand the molecular mechanisms underlying mitochondrial dysfunction in the aging process and diseases, we analyzed accumulation of oxidative damage and mutations in the mitochondrial DNA (mtDNA). 1) Hayakawa et al demonstrated an age-dependent increase in the number of deleted mtDNA was detected in skeletal muscle of human individuals of various ages. 2) Linnane et al used rat administered with AZT to demonstrate the correlation between the contractile function of skeletal muscle with mitochondrial membrane potential of heart submitochondrial particles. They also showed that coenzyme Q_<10> and several analogs can be used as potential therapeutics for the re-energization of affected tissues. 3) Vaillant and Nagley isolated mutants of human Namalwa cells, denoted rho d (mtDNA-depleted), which contain a very low mtDNA copy number. These cells may represent a useful model for human diseases in which severe depletion of cellular mtDNA levels in tissues is encountered. 4) Point mutations of mtDNA were significantly increased in a patient with encephalomyopathy MELAS.5) The amount of 8-hydroxydeoxyguanosine and detectable deleted mtDNA were increased in a patient with cardiomyopathy. 6) A total of 212 different deleted mtDNAs were detected in the heart of a 7-year-old patient who underwent heat transplantation. Thus, the accumulation of both deletions and point mutations contribute to the vicious cycle leading to tissue degeneration associated with aging and diseases.

Report

(2 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (73 results)

All Other

All Publications (73 results)

  • [Publications] Y.Mizuno,S.Ikebe,N.Hattori,Y.Nakagawa-Hattori,H.Mochizuki,M.Tanaka and T.Ozawa: "Role of Mitochondrial in the Etiology and Pathogendsis of Parkinson's Disease" Biochim.Biophys.Acta. 1271. 265-274 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Suzuki,Satoshi.Suzuki,Sanjeev.Kumar and T.Ozawa: "Human Nuclear and Mitochondrial Mt Element-Binding Proteins to Regulatory Regions of the Nuclear Respiratory Genes and to the Mitochondrial Promoter Region" Biochem.Biophys.Res.Commun.213. 204-210 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa,K.Sahashi,Y.Nakase,B.Chance: "Extensive Tissue Oxygenation Associated with Mitochondrial DNA Mutations" Biochem.Biophys.Res.Commun.213:2. 432-438 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Hayakawa,K.Katsumata,M.Yoneda,M.Tanaka,S.Sugiyama and T.Ozawa: "Mitochondrial DNA Minicircles, Lacking Replication Origins,Exist in the Cardiac Muscle of a Young Normal Subject" Biochem.Biophys.Res.Commun.215. 952-960 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Sugiyama,K.Yamada and T.Ozawa: "Preservation of Mitochondrial Respiratory Function by Coenzyme Q10 in Aged Rat Skeletal Muscle" Biochim.Mol.Biol.Int.37. 1111-1120 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sakai,T.Ishizaki,T.Ohnishi,F.Sakai,S.Ameshima,T.Nakai,S.Miyabo,S.Matsukawa,M.Hayakawa and T.Ozawa: "Leukotoxin,9,10-Epoxy-12-Octadecenoate Inhibits Mitochondrial Respiration of Isolated Perfused Rat Lung" Am.J.Physiol.269. L326-L331 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Tanaka,T.Obayashi,M.Yoneda,Sergey A.Kovalenko,S.Sugiyama and T.Ozawa: "Mitochondrial DNA Mutations in Cardiomyopathy : Combination of Replacements Yielding Cysteine Residues and tRNA Mutations" Muscle and Nerve. Suppl3. S165-S169 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Hayakawa,K.Katsumata and T.Ozawa: "Extensive Fragmentation of Mitochondrial DNA Detected Using a Novel Total Detection System." J.Mol.Cell Cardiol.27. A178 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa,K.Katsumata M.Hayakawa,M.Tanaka and S.Sugiyama: "Genotype and Phenotype of Severe Mitochondrial Cardiomyopathy" J.Mol.Cell Cardiol.27. A233 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Kumar,H.Suzuki,S.Onoue,S.Suzuki,N.Hattori,and T.Ozawa: "Rat Mitochondrial mtDNA-Binding Proteins to Inter-Specifically Conserved Sequences in the Displacement Loop Region of Vertebrate mtDNAs" Biochem.Mol.Biol,Int.36(5). 973-981 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Yoneda,T.Miyatake,G.Attardi: "Heteroplasmic Mitochondrial tRNA_<Lys> Mutation and Its Complementation in MERRF Patient-Derived Mitochondrial Transformants." Muscle and Nerve. Suppl3. S95-S101 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Sugiyama,K.Yamada,M.Hayakawa and T.Ozawa: "Approaches That Mitigate Doxorubicin-induced Delayed Adverse Effects on Mitochondrial Function in Rat Hearts ; Liposome-encapsulated Doxorubicin or Combination Therapy with Antioxidant" Biochem.Mol.Biol,Int.36(5). 1001-1007 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa,K.Katsumata,M.Hayakawa,M.Yoneda,M.Tanaka and S.Sugiyama: "Mitochondrial DNA Mutations and Survival Rate" Lancet. 345. 189 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Ikebe,M.Tanaka and T.Ozawa: "Point Mutations of Mitochondrial Genome in Parkinson's Disease" Mol.Brain.Res.28. 281-295 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa,K.Katsumata,M.Hayakawa ,M.Tanaka,S.Sugiyama,T.Tanaka,S.Itoyama,S.Nunoda and M.Sekiguchi: "Genotype and Phenotype of a Severe Mitochondrial Cardiomyopathy : a Recipient of Heart Transplantation and the Genetic Control" Biochem.Biophys.Res.Commun.207. 613-620 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Yoneda,K.Katsumata,M.Hayakawa ,M.Tanaka and T.Ozawa: "Oxygen Stress Induces an Apoptotic Cell Death Associated with Fragmentation of Mitochondrial Genome" Biochem.Biophys.Res.Commun.209:2. 723-729 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Mechanism of Somatic Mitochondrial DNA Mutations Associated with Age and Diseases" Biochem.Biophys.Acta. 1271. 177-189 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Mitochondrial DNA Mutations Associated with Aging and Degenerative Diseases" Experimental Gerontology. 30. 269-290 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Shimizu,H.Suzuki,Y.Nimura,S.Onoue,M.Nagino,M.Tanaka and T.Ozawa: "Elevated Mitochondrial Gene Expression During Rat Liver Regeneration After Portal Vein Ligation" Hepatology. 22. 1222-1229 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] N.Hattori,H.Suzuki,Y.Wang,S.Minoshima,N.Shimizu.H.Yoshino,R.Kurashima,M.Tanaka,T.Ozawa,and Y.Mizuno: "Structural Organization and Chromosomal Localization of the Human Nuclear Gene (NDUFV2) for the 24-kDa Iron-Sulfur Subunit of Complex I in Mitochondrial Respiratory Chain+" Biochem.Biophis.Res.Commun.216,No.3. 771-777 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Yamada,S.Sugiyama,K.Kosaka,M.Hayakawa and T.Ozawa,: "Early Appearance of Age-associated Deterioration in Mitochondrial Function of Diaphragm and Heart in Rats Treated with Doxorubicin" Exp.Gerontol.30:6. 581-593 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ishizaki,K.Shigemori,T.Nakai,S.Miyabo,T.Ozawa,Shin-Wen Chang,Norbert F Voelkel: "Leukotoxin,9,10-Epoxy-12-Octadecenoate Causes Edematous Lung Injury Via Activation of Vascular Nitric Oxide Synthase" Am.J.Physiol.269. L65-L70 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sakai,T.Ishizaki,T.Ohnishi,F.Sakai,S.Ameshima,T.Nakai,S.Miyabo,S.Matsukawa,M.Hayakawa and T.Ozawa: "Leukotoxin,9,10-Epoxy-12-Octadecenoate Inhibits Mitochondrial Respiration of Isolated Perfused Rat Lung" Am.J.Physiol.269. L326-L331 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ishizaki,K.Shigemori,T.Nakai,S.Miyabo,M.Hayakawa and T.Ozawa,N.F.Voelkel,S.W.Chang: "Endothelin 1 Potentiates Leukotoxin-Induced Edematous Lung Injury" J.Appl.Physiol.79. 1106-1111 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Suzuki,S.Suzuki,T.Sakurai,S.Kumar and T.Ozawa: "A Bovine mtDNA-Binding Protein to a Conserved Sequence Adjacent to the Termination Associated Sequence in the Vertevbrate Mitochondrial Displacement Loop Region" Biochem.Mol.Biol.Int.38:2. 275-283 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T Sakai,T.Ishizaki,T.Ohnishi,F.Sasaki,S.Ameshima,T.Nakai,M.Hayakawa and T.Ozawa: "The Effect of Leukotoxin,9,10-Epoxy-12-Octadecenoate on Mitochondrial Respiration of Isolated Perfused Rat Lung." Am.J.Respir.Cell Mol.Biol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T Sawano,M.Tanaka,k.Ohno,M.Yoneda,Y.Ota,H.Terasaki,S.Awaya and T.Ozawa: "Mitochondrial DNA Mutations Associated with the 11778 Mutation in Leber's Disease" Biochem.Mol.Biol.Int.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Genetic and Functional Changes in Mitochondria Associated with Aging" Physiological Review. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Akaza,T.Nonami,T.Kurokawa,H.Kobayashi,A.Harada,A.Nakao,S.Sugiyama,T.Ozawa and H.Takagi: "Doxorubicin-induced Disturbance of the Energy Metabolism after Hepatectomy" J.Surg.Res.(accepted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T Ozawa: "Role of Mitochondrial DNA in Disease,Apotosis and aging" Proceedings of the Society for Experimental Biology and Medicine. (accepted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa, K.Katsumata, M.Hayakawa, M.Yoneda, M.Tanaka and S.Sugiyama: "Mitochondrial DNA Mutations and Survival Rate" Lancet. 345. 189 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Ikebe, M.Tanaka and T.Ozawa: "Point Mutations of Mitochondrial Genome in Parkinson's Disease" Mol.Brain.Res.28. 281-295 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa, K.Katsumata, M.Hayakawa, M.Tanaka, S.Sugiyama, T.Tanaka, S.Itoyama, S.Nunoda and M.Sekiguchi: "Genotype and Phenotype of a Severe Mitochondrial Cardiomyopathy : a Recipient of Heart Transplantation and the Genetic Control" Biochem.Biophys.Res.Commun.207. 613-620 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Yoneda, K.Katsumata, M.Hayakawa, M.Tanaka and T.Ozawa: "Oxygen Stress Induces an Apoptotic Cell Death Associated with Fragmentation of Mitochondrial Genome" Biochem.Biophys.Res.Commun.209 : 2. 723-729 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Mechanism of Somatic Mitochondrial DNA Mutations Associated with Age and Diseases" Biochem.Biophys.Acta. 1271. 177-189 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Mitochondrial DNA Mutations Associated with Aging and Degenerative Diseases" Experimental Gerontology. 30. 269-290 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Mizuno, S.Ikebe, N.Hattori, Y.Nakagawa-Hattori, H.Mochizuki, M.Tanaka and T.Ozawa: "Role of Mitochondrial in the Etiology and Pathogendsis of Parkinson's Disease" Biochim.Biophys.Acta. 1271. 265-274 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hiroshi Suzuki, Satoshi.Suzuki, Sanjeev.Kumar and T.Ozawa: "Human Nuclear and Mitochondrial Mt Element-Binding Proteins to Regulatory Regions of the Nuclear Respiratory Genes and to the Mitochondrial Promoter Region" Biochem.Biophys.Res.Commun.213. 204-210 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa, K.Sahashi, Y.Nakase, B.Chance: "Extensive Tissue Oxygenation Associated with Mitochondrial DNA Mutations" Biochem.Biophys.Res.Commun.213 : 2. 432-438 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Hayakawa, K.Katsumata, M.Yoneda, M.Tanaka, S.Sugiyama and T.Ozawa: "Mitochondrial DNA Minicircles, Lacking Replication Origins, Exist in the Cardiac Muscle of a Young Normal Subject" Biochem.Biophys.Res.Commun.215. 952-960 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Sugiyama, K.Yamada and T.Ozawa: "Preservation of Mitochondrial Respiratory Function by Coenzyme Q_<10> in Aged Rat Skeletal Muscle" Biochem.Mol.Biol.Int.37. 1111-1120 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sakai, T.Ishizaki, T.Ohnishi, F.Sakai, S.Ameshima, T.Nakai, S.Miyabo, S.Matsukawa, M.Hayakawa and T.Ozawa: "Leukotoxin, 9,10-Epoxy-12-Octadecenoate Inhibits Mitochondrial Respiration of Isolated Perfused Rat Lung" Am.J.Physiol.269. L326-L331 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Tanaka, T.Obayashi, M.Yoneda, Sergey A.Kovalenko, S.Sugiyama and T.Ozawa: "Mitochondrial DNA Mutations in Cardiomyopathy : Combination of Replacements Yielding Cysteine Residues and tRNA Mutations" Muscle and Nerve. Suppl 3. S165-S169 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Hayakawa, K.Katsumata and T.Ozawa: "Extensive Fragmentation of Mitochondrial DNA Detected Using a Novel Total Detection System." J.Mol.Cell Cardiol.27. A178 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa, K.Katsumata, M.Hayakawa, M.Tanaka and S.Sugiyama: "Genotype and Phenotype of Severe Mitochondrial Cardiomyopathy" J.Mol.Cell Cardiol.27. A233 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Kumar, H.Suzuki, S.Onoue, S.Suzuki, N.Hattori, and T.Ozawa: "Rat Mitochondrial mtDNA-Binding Proteins to Inter-Specifically Conserved Sequences in the Displacement Loop Region of Vertebrate mtDNAs" Biochem.Mol.Biol.Int.36 (5). 973-981 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Yoneda, T.Miyatake, G.Attardi: "Heteroplasmic Mitochondrial tRNALys Mutation and Its Complementation in MERRF Patient-Derived Mitochondrial Transformants" Muscle and Nerve. Suppl3. S95-S101 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Sugiyama, K.Yamada, M.Hayakawa and T.Ozawa: "Approaches That Mitigate Doxorubicin-induced Delayd Adverse Effects on Mitochondrial Function in Rat Hearts ; Liposome-encapsulated Doxorubicin or Combination Therapy with Antioxidant" Biochem.Mol.Biol.Int.36 (5). 1001-1007 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Shimizu, H.Suzuki, Y.Nimura, S.Onoue, M.Nagino, M.Tanaka and T.Ozawa: "Elevated Mitochondrial Gene Expression During Rat Liver Regeneration After Portal Vein Ligation" Hepatology. 22. 1222-1229 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] N.Hattori, H.Suzuki, Y.Wang, S.Minoshima, N.Shimizu, H.Yoshino, R.Kurashima, M.Tanaka, T.Ozawa, and Y.Mizuno: "Structural Organization and Chromosomal Localization of the Human Nuclear Gene (NDUFV2) for the 24-kDa Iron-Sulfur Subunit of Complex I in Mitochondrial Respiratory Chain+" Biochem.Biophis.Res.Commun.216, No.3. 771-777 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Yamada, S.Sugiyama, K.Kosaka, M.Hayakawa and T.Ozawa: "Early Appearance of Age-associated Deterioration in Mitochondrial Function of Diaphragm and Heart in Rats Treated with Doxorubicin" Exp.Gerontol.30 : 6. 581-593 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ishizaki, K.Shigemori, T.Nakai, S.Miyabo, T.Ozawa, Shih-Wen Chang, Norbert F Voelkel: "Leukotoxin, 9,10-Epoxy-12-Octadecenoate Causes Edematous Lung Injury Via Activation of Vascular Nitric Oxide Synthase" Am.J.Physiol.269. L65-L70 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sakai, T.Ishizaki, T.Ohnishi, F.Sakai, S.Ameshima, T.Nakai, S.Miyabo, S.Matsukawa, M.Hayakawa and T.Ozawa: "Leukotoxin, 9,10-Epoxy-12-Octadecenoate Inhibits Mitochondrial Respiration of Isolated Perfused Rat Lung" Am.J.Physiol.269. L326-L331 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ishizaki, K.Shigemori, T.Nakai, S.Miyabo, M.Hayakawa and T.Ozawa, N.F.Voelkel, S.W.Chang: "Endothelin 1 Potentiates Leukotoxin-Induced Edematous Lung Injury" J.Appl.Physiol.79. 1106-1111 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Shimizu, H.Suzuki, Y.Nimura, S.Onoue, M.Nagino, M.Tanaka and T.Ozawa: "Elevated Mitochondrial Gene Expression During Rat Liver Regeneration After Portal Vein Ligation" Hepatology. 22. 1222-1229 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] N.Hattori, H.Suzuki, Y.Wang, S.Minoshima, N.Shimizu, H.Yoshino, R.Kurashima, M.Tanaka, T.Ozawa and Y.Mizuno: "Structural Organization and Chromosomal Localization of the Human Nuclear Gene (NDUFV2 for the 24-kDa Iron-Sulfur Subunit of Complex I in Mitochondrial Respiratory Chain+" Biochem.Biophis.Res.Commun.216 No.3. 771-777 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Yamada, S.Sugiyama, K.Kosaka, M.Hayakawa and T.Ozawa: "Early Appearance of Age-associated Deterioration in Mitochondrial Function of Diaphragm and Heart in Rats Treated with Doxorubicin" Exp.Gerontol.30 : 6. 581-593 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Suzuki, S.Suzuki, T.Sakurai, S.Kumar and T.Ozawa: "A Bovine mtDNA-Binding Protein to a Conserved Sequence Adjacent to the Termination Associated Sequence in the Vertebrate Mitochondrial Displacement Loop Region" Biochem.Mol.Biol.Int.38 : 2. 275-283 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sakai, T.Ishizaki, T.Ohnishi, F.Sasaki, S.Ameshima, T.Nakai, M.Hayakawa and T.Ozawa: "The Effect of Leukotoxin, 9,10-Epoxy-12-Octadecenoate on Mitochondrial Respiration of Isolated Perfused Rat Lung." Am.J.Respir.Cell Mol.Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Sawano, M.Tanaka, K.Ohno, M.Yoneda, Y.Ota, H.Terasaki, S.Awaya and T.Ozawa: "Mitochondrial DNA Mutations Associated with the 11778 Mutation in Leber's Disease" Biocchem.Mol.Biol.Int.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Genetic and Functional Changes in Mitochondria Associated with Aging" Physiological Review. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Akaza, T.Nonami, T.Kurokawa, H.Kobayashi, A.Harada, A.Nakao, S.Sugiyama, T.Ozawa and H.Takagi: "Doxorubicin-induced Disturbance of the Energy Metabolism after Hepatectomy" J.Surg.Res.(accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ozawa: "Role of Mitochondrial DNA in Disease, Apotosis and aging" Proceedings of the Society for Experimental Biology and Medicine. (accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Onoue, H.Suzuki, Y.Nimura, Y.Shimizu, M.Nagino, M.Tanaka and T.Ozawa: "Increase of mtDNA-binding proteins and mitochondrial mRNAs in regenerating liver" J.Surg.Res.(accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] W.Sato,M.Tanaka,S.Sugiyama,T.Nemoto,K.Harada,Y.Miura,Y.Kobayashi,A.Goto,G.Takada and T.Ozawa: "Cardiomyopathy and Angiopathy in Patients with Mitochondrial Myopathy,Lactic Acidosis and Stroke-like Episodes" Am.Heart J.128. 733-741 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Hayakawa,K.Katsumata,M.Tanaka,S.Sugiyama, and T.Ozawa: "Fragmentation of human heart mitochondrial DNA associated with premature aging" J.Mol.Cell.Cardiol.26. CCXXI (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sergei,A.Kovalenko,M.Tanaka,Harm-Jan W.Borgeld and T.Ozawa: "A common hot spot for somatic and germline mutations in rat mitochondrial DNA:Analysis by fluorescence-based sscp" Biochem.Mol.Biol.Int.34. 1205-1214 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Furui,O.Kurauchi,M.Tanaka,S.Mizutani,T.Ozawa and Y.Tomoda: "Decrease in Cytochrome c Oxidase and Cytochrome Oxidase Subunit I Messenger Ribonucleic Acid Levels in Preeclamptic Pregnancies" Obstet.Gynecol.84. 283-288 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.A.Kovalenco,M.Tanaka and T.Ozawa: "Simple methods for preparation of plasmid DNA yielding long and accurate sequence data" Nucleic Acids Research. 22. 5771-5772 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ozawa,K.Katsumata,M.Hayakawa,M.Yoneda,M.Tanaka and S.Sugiyama: "Mitochondrial DNA mutations and survival rate" Lancet. 345. 189 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Ikebe,M.Tanaka and T.Ozawa: "Point Mutations of Mitochondrial Genome in Parkinson's Disease" Mol.Brain.Res.28. 281-295 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ozawa,K.Katumata,M.Hayakawa,M.Tanaka,S.Sugiyama,T.Tanaka,S.Itoyama,S.Nunoda and M.Sekiguchi: "Genotype and phenotype of a severe mitochondrial cardiomyopathy; a recipient of heart transplantation and the genetic control" Biochem.Biophsy.Res.Commun.207,. 613-620 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Tanaka,T.Obayashi,M.Yoneda,Sergey A.Kovalenko,S.Sugiyama and T.Ozawa: "Mitochondrial DNA mutations in cardiomyopahty:combination of replacements yielding cysteine residues and tRNA mutations" Muscle and Nerve. (in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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