• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

c-kit Mutant Rats as a Tool for Mast Cell Research-Development and Function

Research Project

Project/Area Number 06044144
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionOsaka University

Principal Investigator

KATAMURA Yukihiko  Osaka University Professor, 医学部, 教授 (70028520)

Co-Investigator(Kenkyū-buntansha) PERDUE Mary h.  McMaster University Associate Professor, 準教授
MARTIN Thomas r.  Harvard University Associate Professor, 助教授
WERSHIL Berry k.  Harvard University Associate Professor, 助教授
GALL Stepham  Harvard大学, 教授
MILLER Hugh r.p.  Edinburgh University Professor, 教授
ARIZONO Naoki  Kyoto Prefectural University of Medicine Professor, 教授
JIPPO Tomoko  Osaka University Assistant, 医学部, 助手 (70252658)
TSUJIMURA Tohru  Osaka University Assistant, 医学部, 助手 (20227408)
HIROTA Seiichi  Osaka University Assistant, 医学部, 助手 (50218856)
GALLI Stephen j.  Harvard University Professor
MARTIN Thomo  Harvard大学, 講師
GALLI Stepha  Harvard大学, 準教授
MILLER Hagh  Edinburgh大学, 教授
有園 直樹  京都府立医科大学, 教授
春日井 務  大阪大学, 医学部, 助手 (80214310)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1995: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1994: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsMast cell / Basophil / Immediate hypersensitivity / C-kit / Stem cell factor / Rat / Mouse / Mast cell-deficient rat / c-kitレセプター / アレルギー / 寄生虫 / アレルギーショック / 近交系ラット / マスト細胞プロテアーゼ
Research Abstract

Mast cells play an important role for immediate hypersensitivity reaction as an effector cell. Deseases that are induced as a result of immediate hypersensitivity reaction such as allergic rhinitis, infantile asthma and atopic dermatitis are increasing in industrialized countries. To analize the role of mast cells in immediate hyper-sensitivity reaction, mast cell-deficient animals are useful. Since we recently found mast cell-deficient Ws/Ws rats, we attempted to colaborate with mast cell researchers of various counties by using Ws/Ws rats. Since the original Ws/Ws rats are not inbred. we attempted to introduce the Ws mutant gene into certain inbred strains. However, we cound not find any suitable inbred strains, under which genetic background appreciable number of Ws/Ws rats could be raised. Therefore, we cleaned Ws/Ws rats of closed colony into specific pathogen-free (SPF) condition. SPF condition is required to send experimental animals to foreign countires. Since production of such Ws/Ws rats in the SPF condition appeared to be satisfactory, we are now planning to send these Ws/Ws andcontrol +/+ rats to Harvard, MaMaster and Edingurgh Universities. We recognized that it took rather long period to obtain useful experimental animals that can be transported to the foreign countires. Tsujimura visited Edinburgh Univeirsty to learn about an infection experiment with Shistomsoma mansoni. Kitamura visited Harvard University to explain the delay of the production of Ws/Ws rats in SPF condition. Galli, Perdue and Westling (on behalf of Miller) visited Osaka University to learn the characters and the breeding method of Ws/Wsrats. We all to gether discussed future colaboration by using Ws/Ws rats.

Report

(2 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Kitamura,Y.: "Regulation of development,survival and neoplastic growth of mast cells through c-kit receptor" International Archives of Allergy and Immunology. 107. 54-56 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kasugai,T.: "Infection of Nippostrogylus brasiliensis induces invasion of mast cell precursors from periptheral blood to small intestine" Blood. 85. 1334-1340 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsujimura,T.: "Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven aminoacids at the juxtamembrane domain" Blood. 87. 273-283 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Rodewald,H.R.: "Identification of a committed precursor for the mast cell lineage" Science. 271. 818-821 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Wershil,B.K.: "Dexamethasone or cyclosporin A suppress mast cell-leukocyte cytomine cascades. Multiple mechanisms of inhibition of IgE-and mast cell-" dependent cutaneous inflamation in the mouse Journal of Immunology. 154. 1391-1398 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Wang,L.: "Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells" American Journal of Physiology. 269. G85-G92 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kitamura,Y.: "Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function" Raven Press, New York, 270 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kitamura,Y.: "Hematopoietic Leneages : Regulat on of cell Production and Development" marcel dekker,New York (in press),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Galli,S.J.: "Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function" Raven Press, 270 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Scudamore,C.L.: "Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function" Raven Press,New York, 270 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kitamura, Y.: "Regulation of development, survival and neoplastic growth of mast cells through c-kit receptor" International Archeves of Allergy and Immunology. 107. 54-56 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kasugai, T.: "Infection of Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine" Blood. 85. 1334-1340 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsujimura, T.: "Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain" Blood. 87. 273-283 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Rodewald, H.R.: "Identification of a committed precursor for the mast cell lineage" Science. 271. 818-821 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Wershil, B.K.: "Dexamethasone of cyclosporin A suppress mast cell-leukocyte cytokine cascades. Multiple mechanisms of inhibition of IgE-and mast cell-" dependent cutaneous inflammation in the mouse Journal of Immunology. 154. 1391-1398 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Wang, L.: "Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells" American Journal of Physiology. 269. G85-G92 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kitamura, Y.: Raven Press, New York. Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function, 91-103 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kitamura, Y.: marcel dekker, New York (in press). Hematopoietic Lineages : Regulation of Cell Production and Development,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Galli, S.J.: Raven Press, New York. Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function, 1-11 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Scudamore, C.L.: Raven Press, New York. Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function, 211-224 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tei,Hideki: "Characterization of mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit." Blood. 83. 916-925 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsujimura,Tohru: "Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation." Blood. 83. 2619-2626 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamasaki,Masaru: "c-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice:age-dependent abolishment of c-kit gene expression" Blood. 83. 3509-3516 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Isozaki,Koji: "Cell type-specific deficiency of c-kit gene expression in mutnat mice of mi/mi geneotype." American Journal of Pthology. 145. 827-836 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Jippo,Tomoko: "Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor." Blood. 84. 2977-2983 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Adachi,Shiro: "Inhibition of attachment between cultured mast cells and fibroblasts by phorbol 12-myristate 13 acetate and stem cell factor" Experimental Hematology. 23. 58-64 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kitamura,Yukihiko: "Gann Mongraph on Cancer Research.Growth Factors in Cell Growth,Morphogenesis and Transformation." Japan Scietific Societies Press, 178 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kitamura,Yukihiko: "Hematopoietic Lineages:Requlation of Cell Production and Development" marcel dekker(in press),

    • Related Report
      1994 Annual Research Report
  • [Publications] Kitamura,Yukihiko: "Immunobiology in Otorhinolaryngology" Kugler Publications, 674 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kitamura,Yukihiko: "Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function" Raven Press(in press),

    • Related Report
      1994 Annual Research Report

URL: 

Published: 1994-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi