| Project/Area Number |
06044208
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
NISHIOKA Kusuki Institute of Medical Science St.Marianna University School of Medicine, Professor, 難病治療研究センター, 教授 (60049070)
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| Co-Investigator(Kenkyū-buntansha) |
GAY Steffen チューリッヒ大学, リウマチ科, 教授
STEFFEN Gay Division of Rheumatology, Zurich University, Professor
STEFFEN Gay チューリッヒ大学, リウマチ科, 教授
森本 幾夫 ハーバード大学, 癌研究所, 準教授
KRIEG Arthur アイオワ大学, 医学部, 教授
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | rheumatoid arthritis / apoptosis / Human T cell leukemia virus type-1 / Fas / Fas L / flavivirus / 滑膜増殖 / Fas抗原 / 骨関節破壊 / HTLV-Itax遺伝子 |
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| Research Abstract |
We have identified the pathogenic component from Human T cell leukemia virus type-1 (HTLV-1) which strongly suggested the association of rheumatoid arthritis (RA). This gene product is HTLV-1 env-P40X and contributed in the synovial proliferation and alternation of T cell recognition process in tissue lesion. These findings are confirmed by either experimental animal models carrying this virus gene or in vitro intransfection to synovial cells.
More, recently, we have several data which suggest the flavivirus family takes some role in the pathogenesis in RA.
On the other hand, we have identified apoptotic process which takes an important role in the RA synovium proliferating and withdrawing process molecular interaction of Fas/Fas L abnormality. This process also takes an important role in the pathophysiology and disease progression of RA.
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