| Project/Area Number |
06045029
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | TOTTORI UNIVERSITY |
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Principal Investigator |
MATSUHASHI Akira FACULTY OF AGRICULTURE,TOTTORI UNIVERSITY,Professor, 農学部, 教授 (00001529)
松橋 皓 (1995) 鳥取大学, 農学部, 教授
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| Co-Investigator(Kenkyū-buntansha) |
NORRDIN R.w FACULTY OF VETERINARY MEDICINE AND BIOMEDICAL SCIENCES,COLORADO STATE UNIVERSITY, 獣医学部, 教授
STASHAK Ted s FACULTY OF VETERINARY MEDICINE AND BIOMEDICAL SCIENCES,COLORADO STATE UNIVERSITY, 獣医学部, 教授
NELSON A.W. コロラド州立大学, 獣医学部, 教授
TANIGAWA Takahiko FACULTY OF MEDICINE,TOTTORI UNIVERSITY,Research Assistant, 医学部, 助手 (80135863)
TANAKA Yoshinori FACULTY OF MEDICINE,TOTTORI UNIVERSITY,Professor, 医学部, 教授 (70029809)
SASHIWA Hitoshi FACULTY OF ENGINEERING,TOTTORI UNIVERSITY,Associate Professor, 工学部, 助教授 (20205884)
SAIMOTO Hiroyuki FACULTY OF ENGINEERING,TOTTORI UNIVERSITY,Associate Professor, 工学部, 助教授 (20186977)
SHIGEMASA Yoshihiro FACULTY OF ENGINEERING,TOTTORI UNIVERSITY,Professor, 工学部, 教授 (00032029)
OKAMOTO Yoshiharu FACULTY OF AGRICULTURE,TOTTORI UNIVERSITY,Research Assistant, 農学部, 助手 (50194410)
MINAMI Saburo FACULTY OF AGRICULTURE,TOTTORI UNIVERSITY,Associate Professor, 農学部, 助教授 (70032307)
NELSON A.wendell FACULTY OF VETERINARY MEDICINE AND BIOMEDICAL SCIENCES,COLORADO STATE UNIVERSITY
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Mucopolysaccharide / Chitosan / Chitin / Wound Healing Accelerataion / Polymorphonuclear / Chemotactic / Chemiluminescence / Granulation |
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| Research Abstract |
1. Development of biomedical materials : beta-chitin which was purified from the soft bone of cuttlefish was utilized for implant materials by freeze drying of it's dope or by vacuum filtration of it's dope to the non-woven fabric of polyester (PNWF). alpha-chitin which was purified from the shell of snow crab was deacetylated by a caustic soda and was utilized for the wound covering material by the treatment of mixer on chitosan threads. (Shigemasa, Saimoto, Sashiwa)
2. Veterinary application of these materials : Chitin sponge was applied to large tissue defects or skin defect, and chitin-PNWF composite was applied to subcutaneous tissue defect, tendon injury, defect of diaphragm, Many wondering effects were noted in many clinical cases. (Matsuhashi, Minami, Okamoto)
3. Investigation of wound healing acceleration mechanism : Many bioactive agents were induced by chitin subcutaneous implantation such as FGF like factor, IL-1, PGE2 and activated compliment. It was clearly demonstrated that chitin and chitosan were a chemotactic factor of PMNs. (Tanaka, Tanigawa, Minami, Okamoto)
4. Investigation of wound healing acceleration on experimental created tendon gap : It was clearly demonstrated that chitin accelerated gap healing in the experimental tendon injury model by the histomorphometric and mechanical testing results. (Nelson, Stashak, Norrdin, Okamoto)
5. Joint seminar : Three times Joint seminars were held. The first joint seminar was herd in CSU (Sept.12-19, '94), the second one was herd in Tottori (Nov.2-9, '94), and final seminar was herd in CSU (Jul.14-24, '95).
6. Publication to the International Congress : The 6th International Congress on Chitin and Chitosan (Gdynia, Poland, 16-19, Aug., '94), World Veterinary Congress '96 (Yokohama, Japan, 3-9, Sept, '95)
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