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Basic Research of carcinogenesis and cancer prevention (carcinogenesis)

Research Project

Project/Area Number 06280110
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionInstitute for Virus Research, Kyoto University

Principal Investigator

ITO Yoshiaki  Professor, Institute for Virus Research, Kyoto University, ウイルス研究所, 教授 (80004612)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Mitsuaki  Professor, The Institute for Medical Science, The Tokyo University, 医科学研究所, 教授 (80012607)
TERADA Masaaki  Director, National Cancer Center Research Institute, 研究所, 所長 (10124421)
KITAGAWA Tomoyuki  Director, Japanese Foundation for Cancer Research, 研究所, 所長 (50085619)
YAMAMURA Ken-ichi  Professor, Kumamoto University, School of Mediciene, 医学部, 教授 (90115197)
NAKAMURA Yuusuke  Professor, The Institute for Medical Science, The Tokyo University, 医科学研究所, 教授 (70217909)
富永 祐民  愛知がんセンター, 研究所, 所長 (30124530)
Project Period (FY) 1994 – 1999
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥69,000,000 (Direct Cost: ¥69,000,000)
Fiscal Year 1999: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1998: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1997: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1996: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1995: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsgenomic stability / dysregulation of cell cycle regulation / histone acetylation / histone deacetylation / EBV and gastric cancer / Tsc-2 / gene trap method / Cajal cell / 発がん / がんの疫学 / 化学発がん / 放射線発がん / ウイルス発がん / がん遺伝子 / がん抑制遺伝子 / 発がん感受性 / 総括班会議 / 計画研究 / シンポジウム / 進捗状況報告会 / 肝炎ウイルス検討会 / 研究(1) / 研究(2) / 検討班 / 「発がん」領域 / 重点シンポジウム / ワークショップ / 総合がん総括班 / 計画研究設定 / 留保金の使途 / 将来検討会
Research Abstract

We found that dysregulation or breakdown of cell cycle regulation and so-called DNA transactions, such as DNA replication, repair and recombination, contribute to the genome instability in several specific areas. Since the discovery of oncogenes, it is a common belief that dysregnlation of transcription is also a basis of oncogenesis. A large body of transcription-related results have been accumulated showing a large number of molecules required for transcriptional regulation by forming a large protein complexes, assembly and remodeling of chromatin, histone acetylation and deacetylation by researchers in this research organization. Eleven most significant research accomplishments made in the past 6 ycars are listed below :
1. Identification of the genes responsible for Nijmegen syndrome, xeroderma pigmentosus type V and related frame shift mutator.
2. Identification of the roles of the Runt domain transcription factor PEBP2 in hematopoiesis, leukemogenesis and osteogenesis.
3. Involvement of EVB in gastric cancer.
4. Identification of Tsc-2 responsible for familial cancer of rat kidney.
5. Induction of liver cancer in transgenic mouse expressing HCV core gene.
6. Oncogenes ski and sno also act as tumor suppressors.
7. Development of a new gene trap method.
8. Identification of receptors for prostanoid involved in colon cancer.
9. Establishment of standard for risk assessment for environmental carcinogenesis.
10. Identification of the cell type of those involved in Cajal mesenteric tumors.
11. Significant advancement in epidemiology.

Report

(7 results)
  • 2000 Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (76 results)

All Other

All Publications (76 results)

  • [Publications] Tsukamoto,Y., Kato,J. and Ikeda,H.: "Silencing factors participate in DNA repair and recombination in S. cerevisiae."Nature. 388. 900-903 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshiyama,H., Shimizu,N. and Takada,K.: "Persistent Epstein-Barr virus infection in a human T-cell line : Unique program of latent virus expression."EMBO J.. 14. 3706-3711 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Cheong,J.-H., Yi,M-K. and Murakami,S.: "Human RPB5, a subunit shared by eukaruotic nuclear polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation."EMBO J.. 14. 143-150 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagata,K., Kawase,H., Handa,H., Yano,K., Yamasaki,M., Ishimi,Y., Okuda,A., Kikuchi,A. and Matsumoto,K.: "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis."Proc.Natl.Acad.Sci.USA. 92. 4279-4283 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagata,T., Gupta,V., Kim,W.-Y., Sali,A., Chait,B., Shigesada,K., Ito,Y. and Werner,M.: "Immunoglobulin motif DNA recognition and heterodimerization for the PEBP2/CBF Runt-domain."Nature Struct.Biol.. 6. 615-619 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura,T., Yamzaki,Y., Hatano,Y. and Miura,I.: "NUP98 is fused to PMX1 homeobox gene in human AML with chromosome translocationt (1 ; 11)(q23 ; p15)."Blood. 94. 741-747 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wada,T., Takagi,T., Yamaguchi,Y., Ferdous,A., Hirose,S., Sugimoto,S., Yano,K., Hartzog,G.A., Winston,F., Buratowski,S., and H handa.: "DSIF, a novel negative transcription elongation factor that regulates RNA polymerase processivity, is composed of human Spt4 and Spt5 homologs."Genes Dev.. 12. 343-356 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kong,D., Suzuki,A., Zou,T.-T., Sakurada,A., Kemp,L.W., Wakatsuki,S., Yokoyama,T., Yamakawa,H., Furukawa,T., Sato,M., Ohuchi,N., Sato,S., Yin,J., Wang,S., Abraham,J.M., Souza,R.F., Smulinski,K.N., Meltzer,S.J. and Horii,A.: "PTEN1 is frequently mutated in primary endometrial carcinoma."Nature Genetics. 17. 143-144 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirota,S., Isozaki,K., Moriyama,Y., Hashimoto,K. Nishida,T., Ishiguro,S., Kawano,K., Hanada,M., Kurata,A., Takeda,M., Turlio,G.M., Matsuzawa,Y., Kanakura,Y., Shimoura,Y. and Kitakura,Y.: "Gain-of function mutations of c-kit in human gastrointestinal stromal tumors."Science. 279. 577-580 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Li,Y., Yokoi,T., Katsuki,M., Wang,J.S., Groopman,J.D. and Kamataki,T: "In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus- specific CYP3A7 gene."Cancer Res.. 57. 641-645 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawate,H., Sakumi,K., Tsuzuki,T., Nakatsuru,Y., Ishikawa,T., Takahashi,S., Takano,H., Noda,T. and Sekiguchi,M.: "Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repeir gene."Proc.Natl.Acad.Sci.USA. 95. 5116-5120 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushijima,T., Yamamoto,M., Suzui,M., Kuramoto,T., Yoshida,Y., Nomoto,T., Tatematsu,M., Sugimura,T., and Nagao,M.: "Chromosomal mapping of genes controlling development, histological grade, depth of invasion and size of rat stomach carcinomas."Cancer Res.. 60. 1092-1096 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsukamoto, Y., Kato, J.and Ikeda, H.: "Silencing factors participate in DNA repair and recombination in S.cerevisiae."Nature. 388. 900-903 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshiyama, H., Shimizu, N.and Takada, K.: "Persistent Epstein-Barr virus infection in a human T-cell line : Unique program of latent virus expression."EMBO J.. 14. 3706-3711 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Cheong, J.-H., Yi, M-K.and Murakami, S.: "Human RPB5, a subunit shared by eukaruotic nuclear polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation."EMBO J.. 14. 143-150 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A.and Matsurnoto, K.: "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis."Proc.Natl., Acad.Sci.USA. 92. 4279-4283 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagata, T., Gupta, V., Kim, W.-Y., Sali, A., Chait, B., Shigesada, K., Ito, Y.and Werner, M.: "Immunoglobulin motif DNA recognition and heterodimerization for the PEBP2/CBF Runt-domain."Nature Struct, Biol.. 6. 615-619 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura, T., Yamzaki, Y., Hatano, Y.and Miura, I.: "NUP98 is fused to PMX1 homeobox gene in human AML with chromosome translocationt (1 ; 11)(q23 ; p15)."Blood. 94. 741-747 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S., and H Handz.: "DSIF, a novel negative transcription elongation factor that regulates RNA polymerase processivity, is composed of human Spt4 and Spt5 homologs."Genes Dev.. 12. 343-356 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sakurada, A., Kemp.L.W., Wakatsuki, S., Yokoyama, T., Yarnakawa, H., Furukawa, T., Sato.M., Ohuchi, N., Sato, S., Yin, J., Wang, S., Abraham, J.M., Souza, R.F., Smolinski, K.N., Meltzer.: "PTEN1 is frequently mutated in primary endometrial carcinoma."Nature Genetics.. 17. 143-144 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Tunio, G.M., Matsuzawa, Y., Kanakura, Y., Shimoura, Y.and Kitakura, Y.: "Gain-of function mutations of c-kit in human gastrointestinal stromal tumors."Science. 279. 577-580 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Li, Y., Yokoi, T., Katsuki, M., Wang, J.S., Groopman, J.D.and Kamataki, T: "In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene."Cancer Res.. 57. 641-645 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawate, H., Sakumi, K., Tsuzuki, T., Nakatsuru.Y., Ishikawa, T., Takahashi, S., Takano, H., Noda, T.and Sekiguchi, M.: "Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repeir gene."Proc.Natl.Acad.Sci.U.S.A.. 95. 5116-5120 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushijima, T., Yamamoto, M., Suzui, M., Kuramoto, T., Yoshida, Y., Nomoto, T., Tatematsu, M., Sugimura, T., and Nagao, M.: "Chromosomal mapping of genes controlling development, histological grade, depth of invasion and size of rat stomach carcinomas."Cancer Res.. 60. 1092-1096 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kim, W. -Y.: "Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains"EMBO J.. 18. 1609-1620 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wada, I.: "Failure to detect genetic alteration of the manes-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene in hepatocellular carcinomas in Japan"Hepatology. 29. 1718-1721 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ochiya, T.: "New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material : the Minipellet"Nature Med.. 5. 707-710 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki, T.: "Down-regulation of INK4 family of cyclin-dependent kinase inhibitors by Tax protein of HTLV-1 through two distinct mechanisms"Virology. 259. 384-391 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Araki, K.: "Exchangeable gene trap using the Cre/mutated lox system"Cell. Mol. Biol.. 45. 737-750 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagasawa, Y.: "Transformation and morphological changes of murine L cells by transfection with a mutated form of β-catenin"Cancer Res.. 59. 3539-3542 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suganuma, M.: "Green tea and cancer chemoprevention"Mutation Res.. 428. 339-344 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwaki,H.: "A modified McMullen's staining for Helicobacter pylori : A high-contrast, visibly prominent method." Helicobacter. 3. 45-48 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inoue,M.: "Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides." J.Biol.Chem.273. 11069-11074 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ahn,M.-Y.: "Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dc13 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AMLI/ETO(MTG8)." Proc.Natl.Acad.Sci.USA. 95. 1812-1817 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanno,T.: "Intrinsic transcriptional activation/inhibition domains of the PEBP2/CBF a subunit revealed in the presence of the β subunit." Mol.Cell.Biol.18. 2444-2454 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ushikubi,F.: "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP_3." Nature. 359. 281-284 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kapadia,G.J.: "Cancer chemopreventive activity of synthetic colorants used in foods, pharmaceuticals and cosmetic preparations." Cancer Lett.129. 87-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ahn M.-Y.: "Negative regulation of granuloytic defferentiation in the myeloid precursor cell line 32Dc13 by ear-2,a mammalian homolog of Drosophila seven-up,and a chimeric leukemogenic gene,AMLIETO(MTG8)." Proc.Natl.Acad.Sci.USA. 95. 1812-1817 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitagawa T.: "The concept of Tenju-gann or Natural-end cancer." Cancer. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahama,Y.: "Molecular cloning and functional anaysis of cDNA encoding a rat leukemia inhibitory factor : towards generation of pluripotent rat embryonal stem cells." Oncogene. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoshida M.: "Molecular biology of HTLV-1 : Deregulation of host cell gene expression and cell cycle." Leukemia. 11. 14-15 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tominaga S.: "An ecological study on diet/nutrition and cancer." Int.J.Cancer. 10. 2-6 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Araki K.: "Targeted integration of DNA using mutant lox sites in embryonic stem cells." Nucleic Acid Res.25. 868-872 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shibata H.: "Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene." Science. 278. 120-123 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito,K.: "c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen." EMBO J.16. 5636-5646 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,Y.: "The Runt domain transcription factor,PEBP2/CBF,and its involvement in human leukemia." Progress in Gene Expression. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,Y.: "Structural alterations of a transcription factor PEBP2/CBF linked to 4 different types of leukemia." J.Cancer Res.Clin.Oncol.122. 266-274 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kagoshima,H.: "Functional dissection of the α and β subunits of transcription factor PEBP2 and the Redox susceptibility of its DNA binding activity." J.Biol.Chem.271. 33074-33082 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ahn,M.-Y.: "Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBFα gene family." Gene. 168. 279-280 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsunashima,K.: "A novel clonality assay for the mouse : Application to hepatocellular carcinomas induced with diethylnitrosamine." Mol.Carcinogenesis. 15. 33-37 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Katoh,M.: "Overexpression of bone morphogenic protein(BMP)-4 mRNA in gastric cancer cell lines of poorly differentiated type." J.Gastroenterol.31. 137-139 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4." EMBO J.15. 1607-1614 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Inoue,M.: "Protective factor against progression from atrophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Miki,M.: "Mutatiaon analysis in the BRCA2 gene in primary breast cancers." Nature Genetics. 13. 245-247 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Qhdo,K.: "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain." Blood. 87. 956-967 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,Y.: "Structural alterations of a transcription factor PEBP2/CBF linked to 4 different types of leukemia." J.Cancer Res.Clin.Oncol.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ahn,M.-Y.: "Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBFα gene family." Gene. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Takahashi,A.: "Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor,PEBP2." Blood. 86. 607-616 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Bae,S.C.: "Cloning,mapping and expression of PEBP2αC,a third gene encoding the mammalian Runt domain." Gene. 159. 245-248 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Lu,J.: "Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF." Mol.Cell.Biol.15. 1651-1661 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Satake,M.: "Expression of the Runt domain-coding PEBP2α genes in T cell during thymic development." Mol.Cell.Biol.15. 1662-1670 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,S.: "Granulocyte macrophage-colony stimulating factor-dependent replication of polyoma virus replicon in hematopoietic cells." J.Biol.Chemi.270. 9615-9621 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Prince M.: "Frequent development of pancreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ishii,H.: "A truncated K-sam product lacking the distal carboxyl-terminal portion provides a reduced level of autophosphorylation and greater resistance against induction of differentiation." Mol.Cell.Biol.15. 6664-3671 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tominaga,S.: "Epidemiology of breast cancer in Japan." Cancer Lett.90. 75-79 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity to CDK4." The EMBO J.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Miura,K.: "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to abut 200 kb on distal chromosome 9q." Cancer Res.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiramatsu,R.: "The 3' enhancer region determines the B/T slpecificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining." Cell. 83. 1113-1123 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakakura,C.: "Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide." Proc.natl.Acad.Sci.USA. 91. 11723-11727 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Bae,S.-C.: "PEBP2αB/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials." Mol.Cell.Biol.14. 3242-3252 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kanda,T.: "Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA binding site." Mol.Cell.Biol.14. 2651-2663 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Inuzuka,M.: "The viral and cellular Rel oncoproteins induce the differentiation of p19 embryonal carcinoma cells." Oncogene. 9. 133-140 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Miyasaka,K.: "Frequent loss of heterozygosity on chromosome 4 in diethylnitrosamine-induced C3H/MSM mouse hepatocellular carcinomas." Mol.Carcinogenesis. (in press). (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hayashi,N.: "Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method." Cancer Res.54. 3853-3856 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirai,H.: "Tax protein of human T-cell leukemia virus type 1 binds to the ankyrin motifs of inhibitory factor kB and induces nuclear translocation of transcription factor NF-kB proteins for transcriptional activation." Proc.natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hayashi,S.-I.: "Interindividual difference in expression of human Ah receptor and related p450 genes." Carcinogeneis. 15. 8101-806 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2019-02-15  

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