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がん診断治療の基礎研究

Research Project

Project/Area Number 06282113
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionOsaka University

Principal Investigator

濱岡 利之  大阪大学, 医学系研究科, 教授 (60028529)

Co-Investigator(Kenkyū-buntansha) 谷口 維紹  東京大学, 医学部, 教授 (50133616)
磨井 正義  金沢大学, がん研, 教授 (80092807)
平岡 真寛  京都大学, 医学部, 教授 (70173218)
今井 浩三  札幌医科大学, 医学部, 教授 (60117603)
鶴尾 隆  東京大学, 分子細胞生物学研究所, 教授 (00012667)
上田 龍三  名古屋市立大学, 医学部, 教授 (20142169)
杉町 圭蔵  九州大学, 医学部, 教授 (00038762)
鈴木 紀夫  東京大学, 医学部, 教授 (10010050)
Project Period (FY) 1994 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥69,000,000 (Direct Cost: ¥69,000,000)
Fiscal Year 1999: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1998: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1997: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1996: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1995: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsがんの早期診断法 / がんの質的診断法 / がん免疫 / がんの遺伝子治療 / がんの分子標的治療 / がん化学療法 / がんの放射線療法 / がん治療 / がん診断 / 免疫療法 / 放射線治療 / 遺伝子治療 / 分子標的治療
Research Abstract

平成6年度に成立したがん治療領域は、本年度は6年目の節目の年にあたる。本領域は、がんの適確な診断や有効な治療を実現するために必要な基礎的な知見を収集・集積することを目的としている。本総括班は、がん治療領域における研究推進の支援、研究成果の総括・研究計画の立案を行ってきた。がん治療領域においては、がんの早期診断法・質的診断法では、遺伝子、染色体、たんぱく分子のがんに伴う変化とその診断への応用のための基礎的研究、さらに、核医学診断の研究を、がん免疫の基礎と免疫療法では、腫瘍抗原ペプチド、各種抗腫瘍性サイトカイン、免疫制御に関わるシグナル伝達の解析を、がんの遺伝子治療では、遺伝子導入法や標的遺伝子についての研究を、がんの分子標的治療では、がん治療の標的分子についての基礎的情報の集積を、がん化学療法では、新規抗がん物質の検索、新規標的分子に対する化学療法の開発、薬剤耐性についての基礎的研究等を、がんの放射線療法では、照射法/照射装置、温熱療法等についての研究を行ってきた。これらの分野において、多くの基礎的研究成果が得られたが、それを平成12年度以降の特定領域研究に継続、発展させることで、がん診断治療に有用な、より一層の成果を得られるものと期待される。

Report

(6 results)
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Ogawa, M., et al.: "A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression"Cancer Res.. 59. 1531-1538 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishimura, Y., et al.: "External beam radiation therapy with or without high-dose-rate intraluminal brachytherapy for patients with superficial esophageal carcinoma"Cancer. 86. 220-228 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mai, M., et al.: "A late phase II clinical study of RP56976 (docetaxel) in patients with advanced or recurrent gastric cancer : a cooperative study group trial (group B)"Gan To kagaku Ryoho. 26. 487-496 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takaoka, A., et al.: "Protein tyrosine kinse Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling"EMBO-J. 18. 2480-2488 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chen, Z., et al.: "ASK1 mediates apoptotic cell death induced by genotoxic stress"Oncogene. 18. 173-180 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okuda, H., et al.: "Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage"Oncogene. 18. 5604-5609 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogawa,M.,et al.: "Multiple roles of IFN-γ in the mediation of IL-12-induced tumor regression." Cancer Research. 58. 2426-2432 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Guo,G.Z.,et al.: "Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines." Int.J.Radiat.Biol.73. 297-302 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamashita,K.,et al.: "Expression and tissue localization of matrixmetalloproteinase 7 (Matrilysin)in human gastric carcinomas.Implications for vesselinvasion and metastasis" Int.J.Cancer. 79. 187-194 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miyazaki,T.,et al: "Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak-signaling Pathway." Genes & Dev.12. 770-775 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Seimiya H.et al.: "Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells." J.Biol.Chem.273. 21187-21193 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takaoka,A.,et al.: "Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene." Oncogene. 16. 1443-1453 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ogawa,M., et.al.: "Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12" Cancer Res.57. 2216-2222 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yang,Y.-F., et.al.: "Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte associated molecule-4 blockade : The effect is manifested only at the restricted tumor-bearing stages." Cancer Res.57. 4636-4041 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata R., et.al.: "An anti-angiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma" J.Radiat.Oncol.Biol.Phys..37. 1107-1113 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fujimoto,T., et.al.: "Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state" J.Immunol.158. 5619-5626 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Penninger,J.M., et.al.: "The interferon refulatory transcription factor IRF-1 controls positive and negative selection of CD8^+ thymocytes" Immunity. 7. 243-254 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Seimiya,H., et.al.: "c-Jun NH2-terminal kinase mediated activation of interleukin-1b converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis" J.Biol.Chem.272. 4631-4636 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maruo,S.: "B Cells Regulate CD40 Ligand-Induced IL-12 Production in Antigen-Presenting Cells(APC)During T Cell/APC Interactions." J.Immunol.158. 120-126 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Maruo,S.: "IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones." J.Immunol.156. 1748-1755 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Morimatsu,A.: "Identification and characterization of a protein found after X-irradiation in human T cell leukemia." J.Radiat.Res.37. 1-11 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,N.: "Cooperation of the tumor suppressors IRF-1 and p53 in response to DNA damage." Nature. 382. 816-818 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mikami,K.: "DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines." Cancer Res.56. 2823-2826 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hangaishi,A.: "Inactivation of multiple tumorsuppressor genes involved in negative regulation of the cell cycle,MTS1/p16INK4A/CDKN2,MTS2/p15INK4B,p53,and Rb gnes primary lymphoid" Blood.87. 4949-4958 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto,N., et al.: "Regulatory mechanisms for production of IFN-γ and TNF by anti-tumor T cells or macrophages in the tumor-bearing state." J. Immunol.154. 2281-2290 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakata,K., et al.: "Further application and evaluation of critical cell number and modifying factors in radiocurability of multicellular spheroids." J. Radiat. Res.36. 17-30 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugimachi,K., et al.: "Carcinogenesis and histogenesis of esophageal carcinoma." Cancer. 75. 1440-1445 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Seimiya,H., et al: "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents." Oncogene.10. 1731-1738 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Washimi,O., et al: "In vivo occurrence of p16 (MTS1) and p15 (MTS2) altercations preferentially in non-small cell lung cancers." Cancer Res.55. 514-517 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamamoto,H., et al: "Suppresion of matrilysin inhibits colon carcinoma cell invasion in vitro." Int. J. Cancer. 61. 218-222 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Zou,J.P.: "Recovery of antitumor CD4^+ T cell responsiveness,suppressed in the tumor-bearing state,by release from tumor burden." J.Cancer Res.Clin.Oncol.120. 279-285 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugimachi,K.: "Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination;a prospective randomized study." Cancer Chemother Pharmacol.33. 336-370 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tanaka,N.: "Cellular commitment to oncogege-induced transformation or apoptosis is dependent on the transcription factor IRF-1." Cell.77. 289-389 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Lee,J.: "Nonenzymatic reductive activation of 7-N-{{2-{[2-(g-L-Glutamylamino)ethyl]dithio}ethyl}}mitomycin C by thiol molecules:a novel mitomycin C derivative on mitomycin C-resistant tumor cells." Cancer Res.54. 2398-2403 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hida,T.: "Ectopic expression of c-kit in small-cell lung cancer." Int.J.Cancer.8. 108-109 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takahashi,A.: "Markedly increased amounts of messenger RNAs for vascular endothelialgrowth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis." Cancer Res.54. 4233-4237 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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