| Project/Area Number |
06303014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 総合 |
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| Research Field |
Chemical pharmacy
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
YAMAZAKI Mikio CHIBA UNIVERSITY,FAC.PHARM.SCI., PROFESSOR, 薬学部, 教授 (70089598)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Yoshimitsu TOKUSHIMA UNIVERSITY,FAC.PHARM.SCI., PROFESSOR, 薬学部, 教授 (40027074)
NAKAGAWA Akira TEIKYO UNIVERSITY,SCH.SCI.ENGIN., PROFESSOR, 理工学部, 教授 (60050548)
TANAKA Haruo KITASATO UNIVERSITY,FAC.PHARM.SCI., PROFESSOR, 薬学部, 教授 (40118823)
IWASAKI Shigeo UNIVERSITY OF TOKYO,INST.MOL.CELL.BIOS., PROFESSOR, 分子細胞生物学研究所, 教授 (00013326)
OHTA Tomihisa TOHOKU UNIVERSITY,FAC.PHARM.SCI., ASSOC.PROFESSOR, 薬学部, 助教授 (50108560)
野副 重男 東北大学, 薬学部, 教授 (50013305)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 1996: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1995: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1994: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | DRUG DEVELOPMENTAL RESEARCH / MICROORGANISM PRODUCT / BIOFUNCTIONAL CONTROL / IMMUNOSUPPRESSIVE ACTIVITY / ANTITUMOR ACTIVITY / MICROTUBULE ASSEMBLY INHIBITION / GP120-CD4 BINDING INHIBITION / ION CHANNEL FORMATION / 生体機能制御活性 / 微生物由来薬品開発 / 微小管機能制御活性 / gp120-CD4結合阻害活性 / 緑膿菌薬剤耐性阻害活性 / イオンチャネル形成機構 / 不斉合成 / 子のう菌 / 担子菌 / 放線菌 / 不完全菌 / 抗微小管活性 / イオン輸送 |
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| Research Abstract |
YAMAZAKI ISOLATED 13 IMMUNOSUPPRESSIVE COMPONENTS INCLUDING 12 NEW ONES,3 MONOAMINE OXIDASE INHIBITORY COMPONENTS,AND 3 NEUROTROPIC COMPONENTS FROM SOME ASCOMYCETES INCLUDING GELASINOSPORA MULTIFORIS,MYCELIA STERILIA DERIVED FROM GELASINOSPORA PSEUDORETICULATA,AND SO ON.OHTA ISOLATED SOME ANTITUMOR AND cAMP PHOSPHODIESTERASE-INHIBITORY COMPONENTS FROM SOME BASIDIOMYCETES INCLUDING RUSSULA SUBNIGRICANS,AND SO ON.IWASAKI INVESTIGATED STRUCTURE-ACTIVITY RELATIONSHIP AND FUNCTIONAL MECHANISM OF SOME NATURAL PRODUCTS HAVING POTENCY TO INHIBIT MICROTUBULE ASSEMBLY,USTILOXIN A FROM A FUNGUS USTILAGINOIDEA VIRENS,ARENASTATIN A FROM A SPONGE DYSIDEA ARENARIA,AND SO ON.TANAKA ISOLATED 4 NOVEL INHIBITORS AGAINST GP120-CD4 BINDING INCLUDING ISOCHROMOPHILONES I AND II FROM PENICILLIUM MULTICOLOR.NAKAGAWA ISOLATED ALGINATELYASE FROM BACILLUS SP.AND PENICILLIC ACID FROM A FILAMENTOUS FUNGUS AS AN INHIBITING PRINCIPLE AGAINST ALGINATE PRODUCTION.IIDA ELUCIDATED THAT THE INFLUX OF Ca^<++> INTO CELLS THROUGH ION CHANNELS FORMED FROM STIMULATION OF TRICHOSPORINS,PEPTAIBOLS FROM A FUNGI IMPERFECTI TRICHODERMA POLYSPORUM,INDUCED CATECHOLAMINE RELEASE.NAGAO ACCOMPLISHED ASYMMETRIC TOTAL SYNTHESIS OF A POTENT IMMUNOSUPPRESSIVE PRINCIPLE FROM AN ASCOMYCETE,ISARIA SINCLAIRII BY MEANS OF A NEWLY DEVELOPED SYNTHETIC METHOD.NAKATA WAS SUCCESSFUL IN TOTAL SYNTHESIS OF MICALAMIDE A,AN ANTITUMOR COMPONENT FROM A MICALE SPONGE,AND HEMIBREVETOXIN B,A TOXIC PRINCIPLE OF A RED TIDE MICROORGANISM,GYMNODIUM BREVE.
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