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A prospective study on the mother-to-infant transmission of hepatitis C virus and the prognosis of the infected infants.

Research Project

Project/Area Number 06304031
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTottori University

Principal Investigator

SHIRAKI Kazuo  Professor, Department of Pediatics, Tottori University, 医学部, 教授 (60010229)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Hiroshi  Prof., Dept.of Hygene, Hiroshima Univ., 医学部, 教授 (30109954)
KUROKI Tetsuo  Assos.Prof., Div.of Blood Transfusion, Osaka City Univ., 医学部, 助教授 (30047328)
MORISHIMA Tsuneo  Assist.Prof., Dept.of Pediat., Nagoya Univ., 医学部, 講師 (90157892)
FUJISAWA Tomoo  Assist.Prof., Dept.of Pediat., National Defense Medical College, 講師
MATSUI Akira  Assoc.Prof., Dept.of Pediat., Jichi Med.College, 助教授 (00159146)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1995: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsHepatitis C / Mother-to-infants infection / Hepatitis C virus / HCV RNA / Vertical transmission / Breast feeding / HCV genotype / Anti-HCV
Research Abstract

Mother-to-infant transmission of hepatitis C virus (HCV) is suspected as one of the most important routes of natural infection of this virus, but its frequency nor factors affecting this infection are not known. Since the carrier status develops even when adults are infected by HCV,which is rare by hepatitis B virus, the retrospective study of the families of HCV carriers cannot elucidate the above mentioned problems. In this research we conducted a prospective follow-up study of the infants born to HCV carrier mothers found by screening or pregnant women.
Pregnant women in six different districts of Japan were screened for serum antibody for HCV (second generation, anti-HCV) and if it was positive the serum HCV RNA was examined using polymerase chain reaction. 0.45 to 1.5% (mean 1%) of the pregnant women were positive for anti-HCV,and 71 to 76% of anti-HCV positive women were also positive for serum HCV RNA.Infants born to anti-HCV positive pregnant women were followed after birth with intervals of one to three months for more than one year after birth, examining their sera for anti-HCV,HCV RNA,as well as transaminase levels. Until now 325 infants had been followed for more than six months after birth, and seventeen of them developed chronic HCV carrier status, all of whom were the products of HCV-RNA positive mothers, and none of the infants born to HCV RNA negative mothers showed the sign of HCV infection. The mean percentage of the development of HCV carrier status was 5.4% among the infants born to HCV RNA positive mothers. There were seven other infants who showed transient infection by HCV before six months of age.
Close evaluation of various factors regarding mother-to-infant infection disclosed that 1) the mothers of HCV infected infants showed higher serum HCV RNA level, but 2) no difference of infection rate was found between HCV genotypes, 3) between the density gradient status of virus particles in sera, nor 4) between breast-fed and bottle-fed infants.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] 梶俊策,飯塚俊之,長田郁夫,原田友一郎,田中雄二,白木和夫: "HCV感染小児におけるbranched DNA probe assayを用いた血清中HCVRNA量の検討" 肝臓. 36. 115-116 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 長田郁夫,梶俊策,白木和夫: "C型肝炎ウイルス母子感染の実体" 小児内科. 27. 549-555 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 長田郁夫,岡本学,梶俊策,飯塚俊之,白木和夫: "C型肝炎ウイルスの感染経路-小児期を中心に-" 肝胆膵. 30. 815-823 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 長田郁夫,梶俊策,飯塚俊之,白木和夫: "C型肝炎ウイルス母子感染のProspective study" 小児科診療. 58. 1381-1387 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 長田郁夫,白木和夫: "HCV母子感染におけるHCV-RNA,HCV-RNA genotype" 日本臨床. 53. 413-418 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 長田郁夫,白木和夫: "C型肝炎感染小児における臨床的病理学的特徴" 日本臨床. 53. 834-840 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 白木和夫,藤沢知雄,森島恒雄,松本脩三他: "小児のC型慢性肝炎に対するインターフェロン-α(BALL-1)の臨床効果について" 小児科臨床. 48. 2067-2094 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 松井 陽: "C型肝炎ウイルス母子感染予防の可能性" Neonatal Care. 8. 1061-1064 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 尾上昌弘,乾あやの,大川貴司,藤澤知雄: "小児C型慢性肝炎の臨床・病理学的検討-基礎疾患別の自然経過を中心として-" 日本小児科学会雑誌. 100. 31-38 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomoo Fujizawa, Ayano Inui, et al.: "Clinical and laboratory observations" Journal of Pediatrics. 127. 660-662 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomoo Fujisawa, Takashi Ohkawa, et al.: "Effects of interferon therapy on serum hepatitis C virus RNA levels in children with chronic hepatitis C" International Hepatdogy Communications. 2. 316-320 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ayano Inul, Tomoo Fujisawa, et al.: "Rapid detection of hepatitis C rirus by direct reverse transcription-polymerase chain reaction" International Hepatology Communications. 3. 126-130 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ayano Inui, Tomoo Fujisawa, et al.: "Histologic activity of the liver in children with transfusion-associated chronic hepatitis C" Journal of Hepatology. 21. 748-753 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西口修平,黒木哲夫,福田勝彦,萩田幸雄,他: "C型肝炎ウイルス感染児の自然経過" 日本臨床. 53. 828-833 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Moriya, F, Sasaki, H, Yoshizawa: "Transmission of hepatitis C virus from mothers to in fants: its frequency and risk factor revisited" Biomed & Pharmacother. 49. 59-64 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 守屋尚,吉澤浩司他: "C型肝炎の経路をめぐるアプローチ-母子感染" Infection Contror. 4. 164-169 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 守屋尚,吉澤浩司他: "C型肝炎ウイルスの母子感染" Neonatal Care. 8. 1044-1049 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomoo Fujisawa, Takashi Ohkawa, Ayano Inui, et al.: "Effects of interferon therapy on serum hepatitis C virus RNA levels in children with chrinic hepatitis C." International Hepatology Communications. Vol.2. 316-320 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomoo Fujisawa, Ayano Inui, Takashi Ohkawa, et al.: "Response to interferon therapy in children with chronic hepatitis C." Journal of Pediatrics. Vol.127, No.4. 660-662 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ayano Inui, Tomoo Fujisawa Haruki Komatus: "Rapid detection of hepatitis C virus by direct reverse transcription-polymerase chain reaction." International Hepatology Communications. Vol.3. 126-130 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 梶俊策,飯塚俊之,長田郁夫,原田友一郎,田中雄二,白木和夫: "HCV感染小児におけるbranched DNA probe assayを用いた血清HCV・RNA量の検討" 肝臓. 36. 115-116 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 長田郁夫,梶俊策,白木和夫: "C型肝炎ウイルス母子感染の実体" 小児内科. 27. 549-555 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 長田郁夫,岡本学,梶俊策,飯塚俊之,白木和夫: "C型肝炎ウイルスの感染経路-小児期を中心に-" 肝胆膵. 30. 815-823 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 長田郁夫,梶俊策,飯塚俊之,白木和夫: "C型肝炎ウイルス母子感染のprospective Study" 小児科診療. 58. 1381-1387 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 長田郁夫,白木和夫: "HCV母子感染におけるHCV-RNA,HCV-RNA genotype" 日本臨牀. 53. 413-418 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 長田郁夫,白木和夫: "C型肝炎感染小児における臨床的病理学的特徴"

    • Related Report
      1995 Annual Research Report
  • [Publications] 白木和夫,藤沢知雄,森島恒雄,松本脩三他: "小児のC型慢性肝炎に対するインターフェロン-α(BALL-1)の臨床効果について" 小児科臨床. 48. 2067-2094 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松井 陽: "C型肝炎ウイルス母子感染予防の可能性" Neonatal Care. 8. 1061-1064 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 尾上昌弘,乾あやの,大川貴司、藤澤知雄: "小児C型慢性肝炎の臨床・病理学的検討-基礎疾患別の自然経過を中心として-" 日本小児科学会雑誌. 100. 31-38 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomoo Fujisawa,Ayano Inui,et al.: "Clinical and laboratory observations" Journal of Pediatrics. 127. 660-662 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomoo Fujisawa,Takashi Ohkawa,et al.: "Effects of interferon therapy on serum hepatitis C virus RNA levels in children with chronic hepatitis C" International Hepatdogy Communications. 2. 316-320 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ayano Inui,Tomoo Fujisawa,et al.: "Rapid detection of hepatitis C virus by direct reverse transcription-polymerase chain reaction" International Hepatology Communications. 3. 126-130 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ayano Inui,Tomoo Fujisawa,et al.: "Histologic activity of the liver in children with transfusion-associated chronic hepatitis C" Journal of Hepatology. 21. 748-753 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 西口修平,黒木哲夫,福田勝彦,荻田幸雄,他: "C型肝炎ウイルス感染児の自然経過" 日本臨牀. 53. 828-833 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Moriya,F.Sasaki,H.Yoshizawa: "Transmission of hepatitis C virus from mothers to infants : its frequency and risk factor revisited" Biomed & Pharmacother. 49. 59-64 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 守屋尚,吉澤浩司他: "C型肝炎の経路をめぐるアプローチ-母子感染" Infection Contror. 4. 164-169 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 守屋尚,吉澤浩司他: "C型肝炎ウイルスの母子感染" Neonatal Care. 8. 1044-1049 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Inui,Tomoo Fujisawa et al: "Histologic activity of the liver in children with transfusion-associated chronic hepatitis C" Journal of Hepatotogy. 21. 748-753 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tomoo Fujisawa,et al: "Effect of Interferon therapy on serum hepatitis C virus RNA Ievels in children with chronic hepatitis C" Int.Hepatol.Commun.2. 316-320 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 乾あやの,藤沢知雄: "直接RT-PCR法による血清からのHCV RNA迅速検出" 肝臓. 35. 399-400 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小松陽樹,藤沢知雄他: "自然経過にて寛解した小児のC型慢性肝炎の検討" 日本小児科学会雑誌. 99. 688- (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohto H.,Matsui A.et al: "Transmlssion of hepatitis C virus from mothers to in fants" New England J.Med.330. 744-750 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梶俊策,長田郁夫,白木和夫他: "HCV感染小児におけるbranched DNA probe assayを用いた血清中HCV RNA量の検討" 肝臓. 36. 115-116 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikuo Nagata,Kazuo Shiraki,et al: "Viral Hepatitis and Liver Disease" Springer-Verlag, 188 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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