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The molecular mechanism controlling the determination and differentiation of muscle lineage cells

Research Project

Project/Area Number 06304053
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionNational Institute of Neuroscience, NCNP

Principal Investigator

NABESHIMA Yo-ichi  Dep.of Mol.Genetics, Natl.Inst.of Neuroscience Director, 神経研究所・遺伝子工学, 部長 (60108024)

Co-Investigator(Kenkyū-buntansha) ENDO Takeshi  Dep.of Biology Faculty of Science Chiba University Associate, 理学部, 助教授 (30194038)
NOJI Sumihare  Dep.of Biological Science and Technology Faculty of Engineering Tokushima Univer, 工学部, 教授 (40156211)
MAKABE Kazuhiro  Dep.of Biology Faculty of Science Kyoto University Assistant, 大学院・理学研究科, 助手 (60222288)
OBINATA Takashi  Dep.of Biology Faculty of Science Chiba University Professor, 理学部, 教授 (40012413)
ASASHIMA Makoto  Dep.of Biology, Tokyo University Professor, 教養学部, 教授 (00090564)
佐藤 矩行  京都大学, 理学部, 助教授 (30025481)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥18,100,000 (Direct Cost: ¥18,100,000)
Fiscal Year 1995: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 1994: ¥9,900,000 (Direct Cost: ¥9,900,000)
KeywordsMyogenic Factors / Myogenin / Muscle development / Gene Targeting / Cell differentiation / Growth factor / Cell culture / bHLH / 筋分化 / アポトーシス / 形態形成 / MyoD family / アクチビン / 筋管形成
Research Abstract

From the co-operative research on the mechanisms controlling the determination and differentiation of muscle lineage cells, the followings were concluded.
1) Myogenin is critical for muscle cell differentiation from myoblasts to myotubes and for the maturation of muscle fibers. MRF4 is expressed rather intensively in residual myotubes of mutant embryos than in myotubes of wild type littermates. Majority of myogenin-/-myotubes degrade at late embryonic stage. Secondary myotubes are scarcely generated. However, some secondary myoblasts are seen at muscle forming regions.
2) The gene cascade required for the induction of muscle lineage cells from animal caps by the addition of actibin, was analyzed and cis regulatory elements regulating the initiation of myf-5 gene expression in early xenopus embryos, was detected.
3) FGF,Shh, BMP,HGF,and Wn't are involved in the induction of muscle cells in chick myotomes and limb buds and the ectopic expression of FGF in lateral mesoderm induces extra-limb.
4) Expression pattern of proteins regulating the polymerization of actin during embryogenesis and cytokinasis, was analyzed and revealed the importance of phosphorilation of cofilin.
5) A novel G-protein expressed in skeletal muscle cells was identified.
6) All actin genes were isolated from ascidian and examined their expressions in early embryos. Interestingly, some actin genes begin to express prior to the initial expression of MyoD.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (165 results)

All Other

All Publications (165 results)

  • [Publications] Hoshino M., Suzuki E., Nabeshima Y., and Hama C.: "Hikaru genki protein is secreted into clefts from an early stage of synapse formation in Drosophila" Development. (in press).

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      1995 Final Research Report Summary
  • [Publications] Yoshida S., Fujisawa-Sehara A., Arai K. and Nabeshima Y.: "Lysophosphatidec acid and bFGF control different modes in proliferating myoblasts" J. Cell Biol.(in press).

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  • [Publications] Yagami-Hiromasa T., Sato T., Kurisaki T., Kamijo K., Nabeshima Y. and Fujisawa-Sehara A.: "A metalloprotease-disintegrin participating in myoblase fusion" Nature. 377. 652-656 (1995)

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  • [Publications] Hirata J., Nakagoshi H., Nabeshima Y. and Matsuzaki F.: "Asymmetric segregation of the homeodomain protein Prospero during Drosophila development" Nature. 377. 627-630 (1995)

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  • [Publications] Kuro-o M., Hanaoka K., Noguchi T., Hiroi Y., Fujimori Y., Takewaki S., Hayashika M., Aikawa M., Katoh H., Miyagishi A., Nagai R., Yazaki Y., and Nabeshima Y.: "Overezpression of sodium-proton exchanger causes salt-sensitive blood pressure elevation in transgenic mice" Circulation Res.76. 148-153 (1995)

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  • [Publications] Nakano, H., Uchiyama, H., Fukui, A., Sugino, H., Asashima, M.: "Inhibin/Activin βA-subunit monomer has Xenopus mesoderm-inducing activity" Hormone Research. S2-991. 1-9 (1995)

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  • [Publications] Koike, H., Nakamura, K., Nishimura, K., Kashima, I., Wiederhold, M. L., Asashima, M.: "Non-invasive assessment of otolith formation during development of the Japanese red-bellied newt, Cynops pyrrhogaster." Hearing Reseaech. 88. 206-214 (1995)

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  • [Publications] Ariizumi, T., Asahshima, M.,: "Head and trunk-taik organizing effects of the gastrula ectoderm of Cynops pyrrhogaster after treatment with activin A" Roux' Archives Develop. Bilo.,. 204. 427-435 (1995)

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  • [Publications] Kinoshita, K., Bessho, T., Asashima, M.: "Onset of the competence to respond to activin A in isolated eight-cell stage Xenopus animal blastomeres." Develop. Growth Differ.37. 303-309 (1995)

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  • [Publications] Yokota, C., Mukasa, T., Higashi, M., Odaka, A., Muroya, K., Uchiyama, H., Eto, Y., Asashima, M. and Momoi, T.: "Activin Induces the Expression of the Xenopus Homologue of Sonic Hedgehog during Mesoderm Formation in Xenopus Explants." Biochem. Biophys. Res. Commun.207(1). 1-7 (1995)

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  • [Publications] M. L. Wiederhold, M. Yamashita, K. A. Larsen, J. S. Batten,H. Koike, M. Asashima: "Development of the otolith and semicircular canalsin the Japanese red-bellied newt, Cynops pyrrhogaster" Hearing REsearch. 84. 41-51 (1995)

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  • [Publications] K. Sekiguchi, C. Yokota, T. Kaname, Q.-Wen-Fan, K. Kadomatsu, M. Asashima, T. Muramatsu: "Restricted expression of Xenopus midkine gene during early development" J. Bilchemistry. 188. 94-100 (1995)

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  • [Publications] T. Yamagishi, S.-I. Nishimatsu, S. Nomura, M. Asashima, K. Murakami and N. Ueno: "Expression of BMP-2,4 genes during Xenopus early development" Zool. Science. 12. 353-358 (1995)

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  • [Publications] C. J. Pfeiffer, M. Asashima, M. Yamashita: "Ultrastructural cytology of the primitive lung of the newt, Cynops pyrrhogaster" J. Submic. Cytol. Path.27. 491-500 (1995)

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  • [Publications] C. J. Pfeffer, M. Yamashita, A. Izumi-Kurokawa, H. Koike, and M. Asashima: "Cytopathologic observation of the lung of adult newts(Cynops pyrrhogaster)on-board the space shuttle, Columbia, During the second international microgravity labolatory experiments" J. Submic. Cytol. Path.27. 501-509 (1995)

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  • [Publications] Y. Mogami, M. Imamizo, M. Yamasita, A. Izumi-Kurotani, M. L. Wiederhold, H. Koike, M. Asashima: "Astronewt: Early development of newt in space" Adv Space Res. 17. 257-263 (1995)

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  • [Publications] S. Hatada, M. Kinoshita, M. Noda, M. Asashima: "Indentification of a Xenopus glutamine synthetase gene abundantly expressed in the embryunic nervous system but not in adult brain" FEBS Letters. 371. 287-292 (1995)

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  • [Publications] T. Ariizumi, M. Asashima: "Control of the embryonic body plan by activin during amphibian development." Zool. Science. 12. 509-521 (1995)

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  • [Publications] C. J. Pfeiffer, M. Asashima: "Ultrastructure of Rhabdias tokyoensis, the Parasitic Nematode of the Japanese Newt Lung." Diseases of Aquatic Organisms. (in press).

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  • [Publications] K. Kinoshita, M. Asashima: "Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition." Development. 121. 1581-1589 (1995)

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  • [Publications] Uchiyama, H., Komazaki, S., Asashima, M., and Kikuyama, S: "Occurrance of immunoreactive actisin B in gonadtrophs, thyrotrophs, and somatotrophs of the Xenopus pituitary" Gen. Comp. Endocrinol.(in press).

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  • [Publications] Ariizumi, T., Komazaki, S., Asashima, M., and G. M. Malacinski: "Activin treated urodele ectoderm: A model experomental system for cardiogenesis." Int. J. Develop. Biol.(in press).

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      1995 Final Research Report Summary
  • [Publications] H. Koike, K. Nakamura, K. Nishimura, I. Kashima, M. L. Wiederhold, M. Asashima: "Non0invasive assessment of otolith formation during development of the Japanese red-vellied newt, Cynops pyrrhogaster." Hearing REsearch. 88. 206-214 (1995)

    • Description
      「研究成果報告書概要(和文)」より
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      1995 Final Research Report Summary
  • [Publications] Nakano, H., Uchiyama, H., Fukui, A., Sugino, H., Asashima, M.: "Comparison of Mesoderm-Inducing Activity with Monomeric and Dimeric Inhibin Alpha and Beta-A Subunits on Xenopus Ectoderm" Hormone Research. 44(suppl2). 15-22 (1995)

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  • [Publications] F. Myokai, N. Washio, Y. Asahara, Yamaai, N. Tanda, T. Ishikawa, S. Aoki, H. Kurihara, Y. Yamamura, T, Saito, K. Matsuo, T. Nakamura, S. Noji, and T. Nohno: "Expression of the hepatocyte growth factor gene during chick limb development" Dev. Dyn.202. 80-90 (1995)

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  • [Publications] T. Takebayashi, M. Iwamoto, A. Jikko, T. Matsumura, M. Enomoto-Iwamoto, F. Myokai, E. Koyama, T. Yamaai, K. Matsumoto, T. Nakamura, K. Kurisu, and S. Noji.: "Hepatocyte growth factor/scatter factor modulates cell motility proliferation, and proteoglycan sysnthesis of chondrocytes" J. Cell Biol.,. 129. 1411-1419 (1995)

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  • [Publications] H. Ohuchi, T. Nakagawa, M. Yamauchi, T. Ohata, H. Yoshioka, T. Kuwana, T. Mima, T. Mikawa, T. Nohno, and S. Noji: "An additional limb can be induced from the flank of the chick embryo by FGF4" Biochem. Biophys. Res. Commun. 209. 809-816 (1995)

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  • [Publications] T. Mima, H. Ohuchi, S. Noji, and T. Mikawa: "FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions" Dev. Bilo.167. 617-620 (1995)

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  • [Publications] T. Nohno, T. Ishikawa, K. Hosokawa, T. Saito, S. Noji, B. B. Koenig, S. R. Klise, D. H. Wolsing, J. S. Rosenbaum: "Identification of a Human type II receptor for Bone Morphogenetic Proein-2 and -4 that forms heteromeric complex with type I receptor" J. Biol. Chem.270. 22522-22526 (1995)

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  • [Publications] T. Ishikawa, H. Yoshioka, H. Ohuchi, S. Noji, T. Nohno.: "Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos" Biochem. Biophys. Res. Commun.216. 26-33 (1995)

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  • [Publications] Ono, S., Minami, N., Abe, H., and Obinata T.: "Characterization of a Novel Confilin Isoform That Is Predominantly Expressed in Mammalian Skeletal Muscle" J. Biol. Chem. 269. 15280-15286 (1995)

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  • [Publications] Ohtsuka, Y., Nakae, H., Abe, H., and Obinata, T.: "Immunochemical Studies of an Actin-Binding Protein in Ascidian Body Wall Smooth Muscle" Zool. Sci.11. 407-412 (1994)

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  • [Publications] Koshida, S., Kurasawa, M., Yasuda, M., Sato, N., and Obinata, T.: "Assembly of Cardiac C-protein during Myofibrillogenesis in Myogenic Cells in Culture" Cell Struct. Func.20. 253-261 (1995)

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  • [Publications] Yasuda, M., Koshida, S., Sato, N., and Obinata, T.: "Complete Primary Structure of Chicken Cardiac C-Prptein (MyBP-C) and Its Expression in Developing Striated Muscles." J. Mol. Cell. Cardiol.27. 2275-2286 (1995)

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  • [Publications] Nagaoka, R. Kusano, K., Abe, H., and Obinata, T.: "Effects of cofilin on actin filamentous stuctures in cultured muscle cells. Intracellular regulation of cofilin action" J. Cell Sci.108. 581-593 (1995)

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      1995 Final Research Report Summary
  • [Publications] Nagaoka, R., Abe, H. Kusano, K., and Obinata, T.: "Concentration of cofilin, an small actin-binding protein, at the cleavage furrow during cytokinesis" Cell Motil. Cytoskeleton. 30. 1-7 (1995)

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  • [Publications] Abe, H., Obinata, T., Minamide, L. S., and Bamburg, J. R.: "Xenopus laevis ADF/cofilin: a Phosphorylation-Regulated Protein Essential for Development" J. Cell Biol. (in press).

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  • [Publications] Ohkubo, Y., Kishimoto, T., Nakata, T., Yasuda, H., & Endo, T.: "SV40 large T antigen reinduces the cell cycle in terminally differentiated myotubes through inducting Cdk2, Cdc2, and their partner cyclins." Exp. Cell Res.214. 270-278 (1995)

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  • [Publications] Sakurai, T., Abe, Y., Kasuya, Y., Takuwa, N., Shiba, R., m Yamashita, T., Endo, T., & Goto K.: "Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases." J. Biol. Chem.269. 14118-14122 (1995)

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  • [Publications] Fukami, K., Sawada, N., Endo, T., & Takenawa, T.: "Identification of a phosphatibylinositol 4,5-bisphosphate-binding site in chicken skeletal muscle a-actinin." J. Biol. Chem.271. 2646-2650 (1995)

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  • [Publications] Yajima, H., Ohtsuka, H., Kume, H., Endo, T., Maruyama, K., Kimura, S., & Maruyama, K.: "Molecular cloning of a partial cDNA clone encoding the C terminal region of chicken breast muscle connectin." Zool. Sci.13. 119-123 (1996)

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  • [Publications] Noriyuki Satoh, Kazuhiro W. Makabe, You Katuyama, Shuichi Wada, and Hidetoshi Saiga: "The ascidian embryo: An experimental system for studing genetic circuitry for embryonic cell specification and morphogenesis." Dev. Growth Differ.(in press). (1996)

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  • [Publications] Sekido R., Murai K., Funahashi J., Kamachi Y., Fujisawa-Sehara A., Nabeshima Y. and Kondoh H.: "δ-Crystallin enhancer binding protein δEFl is a repressor of E2-Box-mediated gene activation" Mol. Cell. Biol.14. 5692-5700 (1994)

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  • [Publications] Kinoshita, K. and M. Asashima:"Growth factors and cell differentiation during early amphibian development" Gann Monograph(ed. By T. Nakamura),. 42. 63-78 (1994)

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  • [Publications] Fukui, A., Nakamura, T., Uchiyama, H., Sugino, H., Sugino, K., and Asashima, M.: "Identification of activins A, AB, and B and follistatin proteins in Xenopus embryos." Develop. Biol.163. 279-281 (1994)

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  • [Publications] H. Uchiyama, T. Nakamura, S. Komazaki, K. Takio, M. Asashima and H. Sugino: "Localization of activin and follistatin proteins in the Xenopus Oocyte" Biochem. Biophys. Res. Commun. 202. 484-489 (1994)

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  • [Publications] A. Fukui and M. Asashima: "Control of cell differentiation and morphogenesis in amphibian development" Int. J. Develop. Biol.38. 257-266 (1994)

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  • [Publications] F. M. Jones, C. Pfeiffer, and M. Asashima: "Ultrastructure of the olfactory organ of the newt, Cynops pyrrhogaster" Annals of Anatomy. 176. 269-275 (1994)

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  • [Publications] M. Kinoshita, S. Hatada, M.Asashima, and M. Noda: "HMG-X, a Xenopus gene encoding an HMGl homolog, is abundantly expressed in the developing nervous system" FEBS Letter. 352. 191-196 (1994)

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  • [Publications] Asashima, M.: "Mesoderm induction during early amphibian development" Develop. Growth & Differ.36(4). 343-355 (1994)

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  • [Publications] Ariizimi T. and M. Asashima: "In vitro control of the embryonic form of Xenopus laevis by activin A: Time and dose-dependent inducing properties of activin-treated ectoderm." Develop. Growth & Differ.36(5). 499-507 (1994)

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  • [Publications] Wiederhold, M. L., Yamashita, M. Larsen, K., Asashima, M.: "Formation of otoconia in the Japanese red-bellied newt, Cynops Pyrrhogaster" Adv. Space Res.14(8). 327-330 (1994)

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  • [Publications] Asashima, M., Fukui. A., Sugino, H., and Ariizumi, T.: "Control of cell differentiation and morphogenesis during Xenopus development" Proc. 8th International Conference of Differentiation, Hiroshima. 118-121 (1994)

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  • [Publications] Suzuki, T, Kurokawa, T., and Asashima, M.: "Identification of a heparin-binding, mesoderm-inducing peptide in the swim-bladder of the red seabream, Pagrus major: a probable fishi filbroblast growth factor" Fish Physiology and Biochemistry. 13(4). 343-352 (1994)

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  • [Publications] H. Ohuchi, H. Yoshioka, A. Tanaka, Y. Kawakami, T. Nohno, and S. Noji.: "Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis" Biochem. Biophys. Res. Comm.204. 882-888 (1994)

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  • [Publications] Yamano, K., Takano-Ohmuro, H., and Obinata, T.: "Effect of thyroid hormone on developmental transition of myosin light chains during flunder metamorphosis" Gen. Comp. Endocrinol.93. 321-326 (1994)

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  • [Publications] Fukami, K., Endo, T., Imamura, M., & Takenawa, T.: "a-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase" J. Biol. Chem.269. 1518-1522 (1994)

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  • [Publications] Maruyama, K., Endo, T., Kume, H., Kawamura, Y., Kanzawa, N., Kimura, S., Kawashima, S., & Maruyama, K.: "A partial connectin cDNA encoding a novel type of RSP motifs isolated from chicken embryonic skeletal muscle" J. Biochem.115. 147-149 (1994)

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  • [Publications] Hashimoto, N., Ogashiwa, M., Okumura, E., Endo, T., Iwashita, S., & Kishimoto, T.: "Phosphorylation of a proline-directed kinase motif is responsible for structural changes in myogenin" FEBS Lett.352. 236-242 (1994)

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      1995 Final Research Report Summary
  • [Publications] Hoshino M., Suzuki E., Nabeshima Y., and Hama C.: "Hikaru genki protein is secreted into clefts from an early stage of synapse formation in Drosophila" Development. (in press).

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    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshida S., Fujisawa-Sehara A., Arai K.and Nabeshima Y: "Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts" J.Cell Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yagami-Hiromasa T., Sato T., Kurisaki T., Kamijo K., Nabeshima Y.and Fujisawa-Sehara A.: "A metalloprotease-disintegrin participating in myoblast fusion" Nature. 377. 652-656 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirata J., Nakagoshi H., Nabeshima Y.and Matsuzaki F.: "Asymmetric segregation of the homeodomain protein Prospero during Drosophila development." Nature. 377. 627-630 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuro-o M., Hanaoka K., Noguchi T., hiroi Y., Fujimori Y., Takewaki S., Hayasaka M., Aikawa M., Katoh H., Miyagishi A., Nagai R., Yazaki Y., and Nabeshima Y.: "Overezpression of sodium-proton exchanger causes salt-sensitive blood pressure elevation in transgenic mice." Circulation Res.76. 148-153 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakano.H., Uchiyama.H., Fukui, A., Sugino.H., Asashima, M.: "Inhibin/Activin betaA-subunit monomer has Xenopus mesoderm-inducing activity" Hormone Research. S2-2991. 1-9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Koike, H., Nakamura, K., Nishimura, K., Kashima, I., Wiederhold.M.L., Asashima, M.: "Non-invasive assessment of otolith formation during development of the Japanese red-bellied newt, Cynops pyrrhogaster." Hearing Reseaech. 88. 206-214 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ariizumi, T., Asashima, M.: "Head and trunk-tail organizing effects of the gastrula ectoderm of Cynops pyrrhogaster after treatment with activin A." Roux'Archives Develop.Biol.204. 427-435 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kinoshita, K., Bessho, T., Asashima, M.: "Onset of the competence to respond to activin A in isolated eight-cell stage Xenopus animal blastomeres." Develop.Growth Differ.37. 303-309 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yokota, C., Mukasa, T., Higashi, M., Odaka, A., Muroya, K., Uchiyama, H., Eto, Y., Asashima, M.and Momoi, T.: "Activin Induces the Expression of the Xenopus Homologue of Sonic Hedgehog during Mesoderm Formation in Xenopus Explants." Biochem.Biophys.Res.Commun.207 (1). 1-7 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.L.Wiederhold, M.Yamashita, K.A..Larsen, J.S.Batten, H.Koike, M.Asashima: "Development of the otolith and semicircular canalsin the Japanese red-bellied newt, Cynops pyrrhogaster" Hearing Research. 84. 41-51 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Sekiguchi, C.Yokota, T.Kaname, Q.-Wen-Fan, K.Kadomatsu, M.Asashima, T.Muramatsu: "Restricted expression of Xenopus midkine gene during early development." J.Biochemistry. 118. 94-100 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Yamagishi, S.-I.Nishimatsu, S.Nomura, M.Asashima, K.Murakami and N.Ueno: "Expression of BMP-2,4 genes during Xenopus early development" Zool.Science. 12. 353-358 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] C.J.Pfeiffer, M.Asashima, M.Yamashita: "Ultrastructural cytology of the primitive lung of the newt, Cynops pyrrhogaster" J.Submic.Cytol.Path.27. 491-500 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] C.J.Pfeiffer, M.Yamashita, A.Izumi-Kurokawa, H,Koike, and M.Asashima: "Cytopathologic observation of the lung of adult newts (Cynops pyrrhogaster) on-board the space shuttle, Columbia, during the second international microgravity labolatory experiments" J.Submic.Cytol.Path.27. 501-509 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Y.Mogami, M.Imamizo, M.Yamasita, A.Izumi-Kurotani, M.L.Wiederhold, H.Koike, M.Asashima: "Astronewt : Early development of newt in space." Adv.Space Res.17. 257-263 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Hatada, M.Kinoshita, M.Noda, M.Asashima: "Indentification of a Xenopus glutamine synthetase gene abundantly expressed in the embryunic nervous system but ont in adult brain." FEBS Letters. 371. 287-292 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Ariizumi, M.Asashima: "Control of the embryonic body plan by activin during amphibian development." Zool.Scince. 12. 509-521 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] C.J.Pfeiffer, M.Asashima: "Ultrastructure of Rhabdias tokyoensis, the Parasitic Nematode of the Japanese Newt Lung." Diseases of Aquatic Organisms. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kinoshita, M.Asashima: "Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition." Development. 121. 1581-1589 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Uchiyama, H,Komazaki, S., Asashima, M., and Kikuyama, S.: "Occurrance of immunoreactive actision B in gonadtrophs, thyrotrophs, and somatotrophs of the Xenopus pituitary." Gen.Comp.Endocrinol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ariizumi, T., Komazaki, S., Asashima, M., and G.M.Malacinski: "Activin treated urodele ectoderm : A model experomental system for cardiogenesis." Int.J.Develop.Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Koike, K.Nakamura, K.NIshimura, I.Kashima, M.L.Wiederhold, M.Asashima: "Non-invasive assessment of otolith formation during development of the Japanese red-bellied newt, Cynops pyrrhogaster." Hearing Research. 88. 206-214 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakano, H., Uchivama, H., Fukui, A., Sugino, H., Asashima, M.: "Comparison of Mesoderm-Inducing Activity with Monomeric and Dimeric Inhibin Alpha and Beta-A Subunits on Xenopus Ectoderm." Hormone Research. 44 (suppl 2). 15-22 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] F.Myokai, N.Washio, Y.Asahara, T.Yamaai, N.Tanda, T.Ishikawa, S.Aoki, H.Kurihara, Y.Yamamura, T.Saito, K.Matsuo, T.Nakamura, S.Noji, and T.Nohno.: "Expression of the hepatocyte growth factor gene during chick limb development." Dev.Dyn.202. 80-90 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Takebayashi, M.Iwamoto, A.Jikko, T.Matsumura, M.Enomoto-Iwamoto, F.Myokai, E.Koyama, T.Yamaai, K.Matsumoto, T.Nakamura, K,Kurisu, and S.Noji.: "Hepatocyte growth factor/scatter factor modulates cell motility proliferation, and proteoglycan sysntesis of chondrocytes." J.Cell Biol.129. 1411-1419 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] H.Ohuchi, T.Nakagawa, M.Yamauchi, T.Ohata, H.Yoshioka, T.Kuwana, T.Mima, T.Mikawa, T.Nohno, and S.Noji.: "An additional limb can be induced from the flank of the chick embryo by FGF4." Biochem.Biophys.Res.Commun.209. 809-816 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Mima, H.Ohuchi, S.Noji, and T.Mikawa: "FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions." Dev.Biol.167. 617-620 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Nohno, T.Ishikawa, K.Hosokawa, T.Saito, S.Noji, B.B.Koenig, S.R.Klise, D.H.Wolsing, J.S.Rosenbaum.: "Identification of a Human type II receptor for Bone Morphogenetic Proein-2 and-4 that forms heteromeric complex with type I recetptor." J.Biol.Chem.270. 22522-22526 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] T.Ishikawa, H.Yoshioka, H.Ohuchi, S.Noji, T.Nohno.: "Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos" Biochem.Biophys.Res.Commun.216. 26-33 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Ono, S., Minami, N., Abe, H., and Obinata T.: "Characterization of a Novel Cofilin Isoform That Is Predominantly Expressed in Mammalian Skeletal Muscle." J.Biol.Chem.269. 15280-15286 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Ohtsuka, Y., Nakae, H., Abe, H., and Obinata, T.: "Immunochemical Studies of an Actin-Binding Protein in Ascidian Body Wall Smooth Muscle." Zool.Sci.11. 407-412 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Koshida, S., Kurasawa, M., Yasuda, M., Sato, N., and Obinata, T.: "Assembly of Cardiac C-protein during Myofibrillogenesis in Myogenic Cells in Culture." Cell Struct.Func.20. 253-261 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Yasuda, M., Koshida, S., Sato, N., and Obinata, T.: "Complete Primary Structure of Chicken Cardiac C-Protein (MyBP-C) and Its Expression in Developing Striated Muscles." J.Mol.Cell.Cardiol.27. 2275-2286 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Nagaoka, R.Kusano, K., Abe, H., and Obinata, T.: "Effects of cofilin on actin filamentous structures in cultured muscle cells.Intracellular regulation of cofilin action." J.Cell Sci. 108. 581-593 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nagaoka, R., Abe, H.Kusano, K., and Obinata, T.: "Concentration of cofilin, an small actinbinding protein, at the cleavage furrow during cytokinesis." Cell Motil.Cytoskeleton. 30. 1-7 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Abe, H., Obinata, T., Minamide, L.S., and Bamburg, J.R.: "Xenopus laevis ADF/cofilin : a Phosphorylation-Regulated Protein Essential for Development." J.Cell Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohkubo, Y., Kishimoto, T., Nakata, T., Yasuda, H., & Endo, T.: "SV40 large T antigen reinduces the cell cycle in terminally differentiated myotubes through inducing Cdk2, Cdc2, and their partner cyclins." Exp.Cell Res.214. 270-278 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sakurai, T., Abe, Y., Kasuya, Y., Takuwa, N., Shiba, R., Yamashita, T., Endo, T., & Goto K.: "Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases." J.Biol.Chem.269. 14118-14122 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fukami, K., Sawada, N., Endo, T., & Takenawa, T.: "Identification of a phosphatidylinositol 4,5-bisphosphate-binding site in chicken skeletal muscle a-actinin." J.Biol.Chem.271. 2646-2650 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yajima, H., Ohtsuka, H., Kume, H., Endo, T.Maruyama, K., Kimura, S., & Maruyama, K.: "Molecular cloning of a partial cDNA clone encoding the C terminal region of chicken breast muscle connectin." Zool.Sci.13. 119-123 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Noriyuki Satoh, Kazuhiro W.Makabe, You Katuyama, Shuichi Wada, and Hidetoshi Saiga: "The ascidian embryo : An experimental system of studing genetic circuitry for embryonic cell specification and morphogenesis." Dev.Growth Differ.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sekido R., Murai K., Funahashi J., Kamachi Y., Fujisawa-Sehara A., Nabeshima Y.and Kondoh H.: "delta-Crystallin enhancer binding protein deltaEFl is a repressor of E2-Box-mediated gene activation." Mol.Cell.Biol.14. 5692-5700 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kinoshita, K.and M.Asashima: "Growth factors and cell differentiation during early amphibian development." Gann Monograph (ed.By T.Nakamura). 42. 63-78 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fukui, A., Nakamura, T., Uchiyama, H., Sugino, H., Sugino, K., and Asashima, M.: "Identification of activins A,AB,and B and follistatin proteins in Xenopus embryos." Develop.Biol.163. 279-281 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Uchiyama, T.Nakamura, S.Komazaki, K.Takio, M.Asashima and H.Sugino: "Localization of activin ana follistatin proteins in the Xenopus Oocyte Biochem." Biophys.Res.Commun.202. 484-489 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Fukui and M.Asashima: "Control of cell differentiation and morphogenesis in amphibian development" Int.J.Develop.Biol.38. 257-266 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] F.M.Jones, C.Pfeiffer, and M.Asashima: "Ultrastructure of the olfactory organ of the newt, Cynops pyrrhogaster" Annals of Anatomy. 176. 269-275 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Kinoshita, S.Hatada, M.Asashima, and M.Noda: "HMG-X,a Xenopus gene encoding an HMGl homolog, is abundantly expressed in the developing nervous system." FEBS Letter. 352. 191-196 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asashima, M.: "Mesoderm induction during early amphibian development" Develop.Growth & Differ.36 (4). 343-355 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ariizimi T.and M.Asashima: "In vitro control of the embryonic form of Xenopus laevis by activin A Time and dose-dependent inducing properties of activin-treated ectoderm." Develop.Growth & Differ.36 (5). 499-507 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Wiederhold, M.L., Yamashita, M., Larsen, K., Asashima, M.: "Formation of otoconia in the Japanese red-bellied newt, Cynops Pyrrhogaster." Adv.Space Res.14 (8). 327-330 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asashima, M., Fukui.A., Sugino, H., and Ariizumi, T.: "Control of cell differentiation and morphogenesis during Xenopus development." Proc.8th International Conference of Differentiation, Hiroshima. 118-121 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suzuki, T., Kurokawa, T., and Asashima, M.: "Identification of a heparin-binding, mesoderminducing peptide in the swim-bladder of the red seabream, Pagrus major : a probable fish filbroblast growth factor." Fish Physiology and Biochemistry. 13 (4). 343-352 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Ohuchi, H.Yoshioka, A.Tanaka, Y.Kawakami, T.Nohno, and S.Noji.: "Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis." Biochem.Biophys.Res.Comm.204. 882-888 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Yamano, K., Takano-Ohmuro, H., and Obinata, T.: "Effect of thyroid hormone on developmental transition of myosin light chains during flounder metamorphosis." Gen.Comp.Endocrinol.93. 321-326 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Fukami, K., Endo, T., Imamura, M., & Takenawa, T.: "a-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase." J.Biol.Chem.269. 1518-1522 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maruyama, K., Endo, T., Kume, H., Kawamura, Y., Kanzawa, N., Kimura, S., Kawashima, S., & Maruyama, K.: "A partial connectin cDNA encoding a novel type of RSP motifs isolated from chicken embryonic skeletal muscle." J.Biochem.115. 147-149 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
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      1995 Final Research Report Summary
  • [Publications] Hashimoto, N., Ogashiwa, M., Okumura, E., Endo, T., Iwashita, S., & Kishimoto, T.: "Phosphorylation of a proline-directed kinase motif is responsible for structural changes in myogenin." FEBS Lett. 352. 236-242 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hoshino M., Suzuki E., Nabeshima Y., and Hama C.: "Hikaru genki protein is secreted into clefts from an early stage of synapse formation in Drosophila." Development. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida S., Fujisawa-Sehara A., Arai K. and Nabeshima Y.: "Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts." J. Cell Biol.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Yagami-Hiromasa T., Sato T., Kurisaki T.,Kamijo K., Nabeshiwa Y. and Fujisaki-Sehara A.: "A metalloprotease-disintegrin particingpata in myoblast fusion" Nature 377. 652-656 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirata J., Nakagoshi H., Nabeshima Y. and Matsuzaki F.: "Asymmetric segregation of the homeodomain protein Prospero during Drosophila development." Nature 377. 627-630 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kuro-o M., Hanaoka K., Noguchi T., Hiroi Y., Fujimori Y., Takewaki S., Hayasaka M., Aikawa M., Katoh H., Miyagishi A., Nagai R., Yazaki Y., and Nabeshima Y.: "Overezpression of sodium-proton exchanger causes salt-sensitive blood pressure elevation in transgenic mice" Circulation Res.76. 148-153 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakano, H., Uchiyama, H., Fukui, A., Sugino, H., Asashima, M.: "Inhibin/Activin βA-subunit monomer has Xenopus mesoderm-inducing activity" Hormone Resesrch. S2-991. 1-9 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koike, H., Nakamura, K., Nishimura, K., Kashima, I., Wiederhold, M.L., Asashima, M.: "Non-invasive assessment of otolith formation during development of the Japanses red-bellied newt, Cynops pyrrhogaster" Hearing Resech. 88. 206-214 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ariizumi, T., Asachima, M.: "Head and trunk-tail organizing effects of the gastrula ectoderm of Cynops pyrrhogaster after treatment with activin A." Roux Archives Develop. Biol.,. 2041. 427-435 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kinoshita, K., Bessho, T., Asashima, M.,: "Onset of the competence to respond to activin A in isolated eight-cell stage Xenopus animal blastomers." Develop. Growth Differ. 37. 303-309 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokota, C., Mukasa, T., Higashi, M., Odaka, A., Marota, K., Uchiyama, H., Eto, Y., Asashima, M. and Momoi, T: "Activin Induces the Expression of the Xenopus Homologue of Sonic Hedgehog during Mesoderm Formation in Xenopus Explants" Biochem. Biophys. Res. Commun.,. 207(1). 1-7 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M. L. Wiederhold, M. Yamashita, K. A. Larsen, J. S. Batten, H. Koike, M. Asashima: "Development of the otolith and semicircular canalsin the Japanese red-bellied newt, Cynops pyrrhogaster" Hearing Research. 84. 41-51 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Sekiguchi, C. Yokota, T. Kaname, Q. -Wen-Fan, K. Kadomatsu, M. Asashima, T. Muramatsu: "Restricted expression of Xenopus midkine gene during early development." J. Biochemistry.118. 94-100 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Yamagishi, S-I. Nishimatsu, S. Nomura, M. Asasgima, K. Murakami and N. Ueno: "Expression of BMP-2,4 genes during Xenopus early development." Zool. Science.12. 353-358 (1995)

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      1995 Annual Research Report
  • [Publications] C. J. Pfeiffer, M. Asashima, M.Yamashita: "Ultrastructural cytology of the primitive lung of the newt, Cynops pyrrhogaster" J. Submic. Cytol. Path.27. 491-500 (1995)

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      1995 Annual Research Report
  • [Publications] C. J. Pfeiffer, M. Yamashita, A.Izumi-Kurokawa, H. Koike, and M. Asashima: "Cytopathologic observation of the lung of adult newts (Cynops pyrrhogater) on-board the space shuttle, Columbia, during the second international microgravity labolatory experiments." J. Submic. Cytol. Path.27. 501-509 (1995)

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      1995 Annual Research Report
  • [Publications] Y. Mogami, M. Imamizo, M. Yamasita, A. Izumi-Kurotani, M. L. Wiederhold, H. Koike, M. Asashima: "Astronewt : Early development of newt in space." Adv. Space Res.17. 257-263 (1995)

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      1995 Annual Research Report
  • [Publications] S. Hatada, M. Kinoshita, M. Noda, M. Asashima: "Indentification of a Xenopus glutamine synthetase gene abundantly expressed in the embryunic nervous system but not in adult brain" FEBS Letters. 371. 287-292 (1995)

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      1995 Annual Research Report
  • [Publications] T. Ariizumi, M. Asashima: "Control of the embryonic body plan by activin during amphibian development." Zool. Science. 12. 509-521 (1995)

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      1995 Annual Research Report
  • [Publications] C. J. Pfeiffer, M. Asashima: "Ultrastructure of Rhabdias tokyoensis, the Parasitic Nematode of the Japanese Newt Lung." Diseases of Aquatic Organisms. (in press).

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      1995 Annual Research Report
  • [Publications] K. Kinoshita, M. Asashima: "Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition." Development. 121. 1581-1589 (1995)

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      1995 Annual Research Report
  • [Publications] Uchiyama, H., Komazaki, S., Asashima, M., and Kikuyama, S.: "Occurrance of immunoreactive actisin B in gonadtrophs, thyrotrophs, and somatotrophs of the Xenopus pituitary." Gen. Comp. Endocrinol.(in press).

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      1995 Annual Research Report
  • [Publications] Ariizumi, T., Komazaki, S., Asashima, M., and G. M. Malacinski: "Activin treated urodele ectoderm : A model experomental system for cardiogenesis." Int. J. Develop. Biol.(in press).

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      1995 Annual Research Report
  • [Publications] H. Koike, K. Nakamura, K. NIshimura, I. Kashihima, M. L. Wiederhold, M. Asashima: "Non-invasive assessment of otolith formation during development of the Japanese red-bellied newt, Cynops pyrrhogaster." Hearing Research. 88. 206-214 (1995)

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      1995 Annual Research Report
  • [Publications] Nakano, H., Uchiyama, H., Fukui,A., Sugino, H., Asashima, M.: "Comparison of Mesoderm-Inducing Activity with Monomeric and Dimeric Inhibin Alpha and Beta-A Subunits on Xenopus Ectoderm." Hormone Research. 44(suppl 2),. 15-22 (1995)

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      1995 Annual Research Report
  • [Publications] F. Myokai, N. Washio, Y. Asahara, T. Yamaai. N. Tanda, T. Ishikawa, S. Aoki, H. Kurihara, Y. Yamamura, T. Saito, Y. Matsuo, T. Nakamura, S. Noji, and T. Nohno.: "Expression of the hepatocyte growth factor gene during chick limb development." Dev. Dyn.202. 80-90 (1995)

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      1995 Annual Research Report
  • [Publications] T. Takebayashi, M. Iwamoto, A. Jikko, T. Matsumura, M. Enomoto-Iwamoto, F. Myokai, E. Koyama, T. Yamaai, K. Matsumoto, T. Nakamura, K. Kurisu, and S. Noji: "Hepatocyte growth factor/scatter factor modulates cell motility proliferation, and proteoglycan sysnthesis of chondrocytes." J. Cell Biol.129. 1411-1419 (1995)

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      1995 Annual Research Report
  • [Publications] H. Ohuchi, T. Nakagawa, M. Yamauchi, T. Ohata, H. Yoshioka, T. Kuwana, T. Mima, T. Mikawa, T. Nohno, and S. Noji: "An additional limb can be induced from the flank of the chick embryo by FGF4." Biochem. Biophys. Res. Commun.209. 809-816 (1995)

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      1995 Annual Research Report
  • [Publications] T. Mima, H. Ohuchi, S. Noji, and T. Mikawa: "FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions" Dev. Biol.,. 167. 617-620 (1995)

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      1995 Annual Research Report
  • [Publications] T. Nohno, T. Ishikawa, K. Hosokawa, T. Saito, S. Noji, B. B. Koenig, S. R. Klise, D. H. Wolsing, J. S. Rosenbaum.: "Identification of a Human type II receptor for Bone Morphogenetic Proein-2 and -4 that forms heteromeric complex with type I receptor." J. Biol. Chem.,. 270. 22522-22526 (1995)

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      1995 Annual Research Report
  • [Publications] T. Ishikawa, H. Yoshioka, H. Ohuchi, S. Noji, T. Nohno.: "Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos" Biochem. Biophys. Res. Commun.,. 216. 26-33 (1995)

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      1995 Annual Research Report
  • [Publications] Ono, S., Minami, N., Abe, H., and Obinata T.: "Characterization of a Novel Cofilin Isoform That Is Predominantly Expressed in Mammalian Skeletal Muscle." J. Biol. Chem.269. 15280-15286 (1995)

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      1995 Annual Research Report
  • [Publications] Ohtsuka, Y., Nakae, H., Abe, H.,and Obinata, T.: "Immunochemical Studies of an Actin-Binding Protein in Ascidian Body Wall Smooth Muscle." Zool. Sci.11. 407-412 (1994)

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      1995 Annual Research Report
  • [Publications] Koshida, S., Kurasawa, M., Yasuda, M., Sato, N., and Obinata, T.: "Assembly of Cardiac C-protein during Myofibrillogenesis in Myogenic Cells in Culture." Cell Struct. Func.20. 253-261 (1995)

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      1995 Annual Research Report
  • [Publications] Yasuda, M., Koshida, S., Sato, N., and Obinata, T.: "Complete Primary Structure of Chicken Cardiac C-Protein (MyBP-C) and Its Expression in Developing Striated Muscles." J. Mol. Cell. Cardiol.27. 2275-2286 (1995)

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      1995 Annual Research Report
  • [Publications] Nagaoka, R. Kusano, K., Abe, H., and Obinata, T.: "Effects of cofilin on actin filamentous structures in cultured muscle cells. Intracellular regulation of cofilin action." J. Cell Sci.108. 581-593 (1995)

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      1995 Annual Research Report
  • [Publications] Nagaoka, R., Abe, H. Kusano, K., and Obinata, T.: "Concentration of cofilin, an small actin-binding protein, at the cleavage furrow during cytokinesis." Cell Motil. Cytoskeleton. 30. 1-7 (1995)

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      1995 Annual Research Report
  • [Publications] Abe, H., Obinata, T., Minamide, L. S., and Bamburg, J. R.: "Xenopus laevis ADF/cofilin : a Phosphorylation-Regulated Protein Essential for Development." J. Cell Biol.(in press).

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      1995 Annual Research Report
  • [Publications] Ohkubo, Y., Kishimoto, T., Nakata, T., Yasuda, H., & Endo, T.: "SV40 large T antigen reinduces the cell cycle in terminally differentiated myotubes through inducing Cdk2, Cdc2, and their partner cyclins." Exp. Cell Res.214. 270-278 (1995)

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      1995 Annual Research Report
  • [Publications] Sakurai, T., Abe, Y., Kasuya, Y., Takuwa, N., Shiba, R., Yamashita, T., Endo, T., & Goto K.: "Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases." J. Biol. Chem.269. 14118-14122 (1995)

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      1995 Annual Research Report
  • [Publications] Fukami, K., Sawada, N., Endo, T., & Takenawa, T.: "Identification of a phosphatidylinositol4,5-bisphosphate-binding site in chicken skeletal muscle a-actinin." J. Biol. Chem.271. 2646-2650 (1995)

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      1995 Annual Research Report
  • [Publications] Yajima, H., Ohtsuka, H., Kume, H., Endo, T., Maruyama, K., Kimura, S., & Maruyama, K.: "Molecular cloning of a partial cDNA clone encoding the C terminal region of chicken breast muscle connectin." Zool. Sci.13. 119-123 (1996)

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      1995 Annual Research Report
  • [Publications] Ryohei Sekido,et al: "The δ-crystallien Enhancer-boinding protein δ-EF1 is a Repressor of E_2-Box-mediated gene activation" Mol.Cell.Biol.14. 5692-5700 (1994)

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      1994 Annual Research Report
  • [Publications] Fukui A.Nakamura F.,et.al: "Identification of activin-A,activin-AB,and activin-B and follistatin proteins in Xenopus-embryos" Develop Biol.163. 278-280 (1994)

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      1994 Annual Research Report
  • [Publications] Hikosaka,et al.: "Short upstream sequences associated with the muscle-specific expression of an actin gene in ascidian embryos" Develop Biol.166. 763-769 (1994)

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      1994 Annual Research Report
  • [Publications] Yoshioka,et al.: "Regional expression of the Cwnt-4 gene in developing chick central-nervous system in relationship to the diencephalic neuromere D2 and adorsal domain of the spinal-cord" Biochem.Biophys.Res.Comm.203. 1501-1588 (1994)

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      1994 Annual Research Report
  • [Publications] Ono.S.,et al.: "Characterization of a novel cofilin isoform which is predominantly expressd in mammalian skeletal-muscle." J.Biol.Chem.267. 15280-15286 (1994)

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      1994 Annual Research Report
  • [Publications] Fukami K,et al.: "α-Actinin and vinculin are pip_2 binding proteins involved in signaling by tyrosine kinase" J.Biol.Chem.289. 1518-1522 (1994)

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      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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