| Project/Area Number |
06404060
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
WADA Hiroshi Tohoku Univ., Dept.of Mech.Eng., Professor, 工学部, 教授 (30111264)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Katuhisa Tohoku Univ.School of Medicine, Dept.of Otolaryngol., Lecturer, 医学部, 講師 (70159614)
SATOH Masaaki Tohoku Univ., Dept.of Mech.Eng., Professor, 工学部, 教授 (30111371)
TAKASAKA Tmonori Tohoku Univ.School of Medicine, , Dept.of Otolaryngol., Professor, 医学部, 教授 (80004646)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥28,900,000 (Direct Cost: ¥28,900,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1994: ¥27,600,000 (Direct Cost: ¥27,600,000)
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| Keywords | Outer Hair Cell / Motility / Voltage Stimuli / Measurements / High speed video |
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| Research Abstract |
Although the amplitude of tympanic membrane vibrations is only a few nanometers when we speak in a low voice, we can understand clearly what is being said. This is speculated to be due to the cochlear amplification which is based on the outer hair cells (OHCs) motility. However, the mechanism of OHCs motility in the cochlea is unclear. Therefore, in this study, in order to understand its mechanism, the isolated OHCs motility in response to the voltage stimuli is measured by a high speed video system. Results are as follows : the generation force of the short OHCs taken from the basal region of the cochlea is larger than that of the long OHCs from its apical region ; slthough sinusoidal voltage stimulus produces synchronously oscillatory elongation and shortening of the cells, the center of the oscillation is shifted to the side of shortening.
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