| Project/Area Number |
06404085
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
MIKI Naomasa Osaka University, Medical School, Professor, 医学部, 教授 (40094445)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hidekazu Osaka University, Medical School, Assistant Professor, 医学部, 助手 (70273638)
KAKU Tetsuki Osaka University, Medical School, Assistant Professor, 医学部, 助手 (50126570)
HIGUCHI Hiroshi Osaka University, Medical School, Associate Professor, 医学部, 助教授 (30150337)
平 英一 大阪大学, 医学部, 助手 (60263240)
大杉 武 大阪大学, 医学部, 助手 (50176880)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥15,800,000 (Direct Cost: ¥15,800,000)
Fiscal Year 1996: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1995: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1994: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | gicerin / neurite outgrowth factor cell adhesion / synaptogenesis / cell movement / reactive astrocytes / 反応性アストログリア / 突起伸展因子 / gicerin(ギセリン) / イムノグロブリン / 細胞接着因子 / シナプス形成 / ギセリン / 活性ドメイン / 神経察知伸展因子 / 腎臓 / 発生 / 癌化 |
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| Research Abstract |
We have reported the neurite outgrowth factor (NOF) that induces the neurite outgrowth from chicken ciliary neurons and revealed that it is an extracellular matrix protein which belongs to laminin family. On the other hand, we have isolated gicerin as a NOF receptor, which is a cell adhesion molecule belonging to a immunoglobulin superfamily. Gicerin exhibits both homophilic and heterophilic cell adhesion activities. Gicerin has two isomers (S-and L-) which differ in the length of cytoplasmic domain. Gicerin is expressed only during synaptogenesis and cell movement in development nervous system and thereafter rapidly is decreased. We also found that gicerin is involved in the tubular formation in the renal tubules and bronchus. Gicerin is also expressed in the olfactory bulb and C6 glioma cells. We found that gicerin expression was unregulated in the the injured neurons and reactive astrocytes at 7-14 days after the transection of the hypoglossal nerve. It is suggested that gicerin is involved in the network formation of reactive astrocytes and also the neurite outgrowth from the transected nerve end.
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