| Project/Area Number |
06451015
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
実験系心理学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
IWASAKI Tsuneo University of Tsukuba, Institute of Psychology, Professor, 心理学系, 教授 (70092509)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Miki (TAKASUNA Miki) Yamano College of Aesthetics, Assistant Professor, 講師 (40261763)
ICHITANI Yukio University of Tsukuba, Institute of Psychology, Associate Professor, 心理学系, 助教授 (80176289)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | 6-hydroxydopamine / neonatal treatments / brain dopamine / hyperactivity / stimulant drugs / microdialysis / learning disabilities / rats / 新生仔期処置 |
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| Research Abstract |
Behavioral and biochemical characteristics were investigated in neonatal brain dopamine depleted rats, a possible animal model of hyperactive (learning disability) children. On days 2 and 4 after birth, each rat of F344/Du strain received bilateral intraventricular injections of 6-hydroxydopamine (70mug). The results are as follows.
1. Hyperactivity occurs prominently during the developing (premature) age. 2. Marked learning deficits appears on some (one-way and shuttle) types of avoidance tasks, which might be brought from prominent rearing and jumping responses under stressful situation. 3. Appetitive maze learning is also deteriorated. 4. Rewarding effects to dopaminergic stimulants are not changed. 5. Tissue contents of brain dopamine profoundly decrease, but extracellular concentration of dopamine remains to be relatively high. These results suggest that neonatal dopamine depleted rats are a promising animal model of hyperactive children.
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