Efficient Synthesis of Biologically Active Peptides having Abnormal Amino Acids
| Project/Area Number |
06453190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | NAGOYA CITY UNIVERSITY |
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Principal Investigator |
SHIOIRI Takayuki Nagoya City University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (20012627)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1996: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1995: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1994: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | abnormal amino acids / marine peptide / biologically active peptide / sponge / ペプチド縮合試薬 / サイクロセオナマイド / プロティナーゼ阻害剤 / 生理活性ペプチド / 海洋生物由来ペプチド / テオネラマイドF / ドラスタチン10 / マイクロギニン / 立体選択的合成 |
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| Research Abstract |
An efficient synthesis of biologically active peptides having abnormal amino acids has been achieved. As a coupling reagent, diphenyl phoshorazidate (DPPA,(C_6H_5O)_2P(O)N_3), diethyl phosphorocyanidate (DEPC,(C_2H_5O)P(O)CN), and pentafluorophenyl diphenylphosphinate (FDPP,(C_6H_5)_2P(O)OC_6F_5) were used. The peptides which we have synthesized are dolastatin 10, microginin, jaspamide, geodiamolide, cyclotheonamide B,alterobactin A,and radiosumin. Parts of theonellamide F and microsclerodermins have been also synthesized. The methods we developed will be suitable for the preparation of these peptides and their analogs on a large scale.
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Report
(4 results)
Research Products
(8 results)
