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Molecular population genetic studies on the evolution of retroposons

Research Project

Project/Area Number 06454004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 遺伝
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

TACHIDA Hidenori  Kyushu University, Department of Biology, Associate Professor, 理学部, 助教授 (70216985)

Co-Investigator(Kenkyū-buntansha) NITASAKA Eiji  Kyushu University, Department of Biology, Research Associate, 理学部, 助手 (60222189)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1994: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsretroposon / SINE / LINE / I element / molecular evolution / population genetics / Drosophila
Research Abstract

In order to elucidate evolutionary mechanisms of retroposons, Drosophila I elements were cloned from Drosophila melanogaster and its sibling species and their sequences were determined. Analysis of them showed that I elements invaded populations of D.melanogaster at least twice, before and after the diversification of D.melanogaster and D.simulans and the second invasion occurred recently. We extended the survey to include I-homologous elements in other species groups of Drosophila and silk moth and determined their sequences and distribution on the chromosome. They were diverged from those of D.melanogaster but sometimes have gag^- and revesetranscriptase-like sequnces with TAA repeats. Generally, I elements are found both on chromosome arms and chromocenters but more likely to be on the latter. Because they were found in a wide range of species, their origin is considered to be fairly old.
To understand the dynamics of retroposon evolution, a transient population genetic model of SINE evolution assuming the master copy model was theoretically inverstigated. Means and variances of consensus frequency, nucleotide homozygosity, and the number of shared differences which are considered to have been caused by mutations occurring in the master copy lineages are computed. All quantities investigated are shown to be monotone functions of the duration of the expansion period. Using the theoretical results, the Sb subfamily of fuman Alu sequences is analyzed. The expansion period is estimated to be short compared to the time since the end of the expansion of the subfamily. However, the observed number of the shared differences is about one half of that expected under the master copy model with the estimated expansion period suggesting the presence of multiple master copy loci in the Sb subfamily.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] H.Tachida: "A population genetic study of the evolution of SINEs.II.Sequence evolution under the master copy model." Genetics. 143. 1033-1042 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Murata: "Details of retropositional genome dynamics that provide a rationale for a generic division : the distinct branching of all the pacific salmon and trout (Oncorhynchus) from the Atlantic salmon and trout (Salmo)." Genetics. 142. 915-926 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "Effects of the shape of distribution of mutant effects in nearly neutral mutation models." J.Genetics. 75. 33-48 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Sezutsu: "Evolution of the LINE-like retrotransposon I element in the Drosophila melanogaster species subgroup." Mol.Gen.Genet.249. 168-178 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Nitasaka: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosphila melanogaster." Mol.Gen.Genet.247. 164-168 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "Decay of linkage disequilibrium in a finite island model." Genet.Res.64. 137-144 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "A population genetic study of the evolution of SINEs. II.Sequence evolution under the master copy model" Genetics. 143. 1033-1042 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Murata: "Details of retropositional genome dynamics that provide a rationale for a generic division : the distinct branching of all the pacific salmon and trout (Oncorhynchus) from the Atlantic salmon and trout (Salmo)." Genetics. 142. 915-926 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "Effects of the shape of distribution of mutant effects in nearly neutral mutation models." J.Genetics. 75. 33-48 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Sezutsu: "Evolution of the LINE-like retrotransposon I element in the Drosophila melanogaster species subgroup." Mol.Gen.Genet. 249. 168-178 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Nitasaka: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosphila melanogaster." Mol.Gen.Genet. 247. 164-168 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "Decay of linkage disequilibrium in a finite island model." Genet.Res.64. 137-144 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Tachida: "A population genetic study of the evolution of SINEs.II.Sequence evolution under the master copy model." Genetics. 143. 1033-1042 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] E.Okuyama: "Molecular evolution of the 5'-flanking regions of the duplicated Amy genes in Drosophila melanogater species subgroup." Mol.Biol.Evol.13. 574-583 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Murata: "Details of retropositional genome dynamics that provide a rationale for a generic division:the distinct branching of all the pactic salmon and trout(Oncorhynchus)from the Atlantic salmon and trout(Salmo)." Genetics. 142. 915-926 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Tachida: "Effects of the shape of distribution of mutant effects in nearly neutral mutation models." J.Genetics. 75. 33-48 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Tachida: "Genetic diversity in partially selfing populations with stepping stone structure." Heredity. 77. 469-475 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] B.Richer: "Nucleotide variation and conservation at the dpp locus,a gene controlling early development in Drosophila." Genetics. (発表予定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] H. Tachida: "A population genetic study of the evolution of SIMEs. II. Sequence evolution under the master copy model." Genetics(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] N. Inomata: "Evolution of the reponse patterns to dietary carbohydrates andthe develop-mental differnetiation of gene expression of alpha-Amylase in Drosophila." J. Mol. Evol.41. 1076-1084 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] N. Sezutsu: "Evolution of the LINE-like retrotransposon I element in the Drosophila melanogaster species subgroup. r." Mol. Gen. Genet.249. 168-178 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E. Nitasaka: "New alleles of eye color mutations isolated from natural populations in Drosophila melanogaster." Dros. Info. Serv.76. 79- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E. Nitasaka: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosphila melanogaster." Mol. Gen. Genet. 247. 164-168 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Tachida: "Decay of linkage disequilibrium in a finite idsland model." Genetical Research. 64. 137-144 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Newfeld,S.J.: "Drive-selection equilibrium:Homopolymer evolution in the Drosophila gene mastermind." J.Mol.Evol.38. 637-641 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nitasaka,E.: "The relationship between DNA structural variations and acivities of P elements in P and Q strains of Drosophila melanogaster." Heredity. 73. 608-615 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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