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Physiological role of IGF-I in the nutrition of central nervous system

Research Project

Project/Area Number 06454082
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 食品科学・栄養科学
Research InstitutionThe University of Tokyo

Principal Investigator

NOGUCHI Tadashi  The University of Tokyo, Professor, 農学部, 教授 (50011937)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1994: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsIGF-I / IGF-II / IGF-binding protein / Protein nutrition / Insulin-like growth factor / IGF・I / インスリン様成長因子-I / インスリン様成長因子結合タンパク質 / 神経切断 / インスリン様成長因子I / インスリン様成長因子Iレセプター / インスリン様成長因子I mRNA / インスリン様成長因子レセプターmRNA
Research Abstract

To elucidate the physiological role of IGF-I in the nutrition of central nervous system, the following studies were performed.
(1) Relate the effect of nutrition of the expressioin of IGF-I,IGF-II and IGF-binding protein genes to the mode of nutrient incorporation by the central nervous.
(2) Elucidate the role of nervous system in the nutrition of tissues.
Gene expression of IGF-I,IGF-II and IGF-binding prteins was studied in various portions of rat brain. IGF-I mRNA was found in various portions of brain but it was scarcely found in cerebrum and not so much in cerebellum and midbrain. On the other hand, IGF-II mRNA was found in every portion of brain. Among IGFBP-1 BP-2 and BP-3, only IGFBP-2 mRNA was found in brain extensively. Dictary protein did not affect the mRNA contents of IGF-I,IGF-II and IGFBP-2 in brain, probably reflecting the conservative nature of brain nutrition. It was suggested that brain nutrition is regulated not by endocrine mode of IGF-I action but by autocrine/paracrine mode of IGF-I action.
As for the role of nervous system in the nutrition of tissues, protein metabolism of denervated muscle was studied in detail.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Asako Takenaka 他: "Effect of protein nutrition on insulin-like growth factor-I (IGF-I) receptor in various tissues of rats." J. Nutr. Sci. Vitaminol. submitted.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asako Takenaka et al.: "Effect of protein nutritioni on insulin-like growth factor-I (IGF-I) receptor in various tissues of rats." J.Nutr, Sci.Vitaminol.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TAKENAKA,A.: "Nutritional regulation of gene expression of insulin-like growth factor-binding profeins and the acid-labile subunit in various tissues of rats." J.Endocrinol.(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] NOGUCHI,T.: "Gene expression of IGF-I and IGF-binding proteins." J.Reproduction and Development. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] KIDA,S.,NOGUCHI,T.et al.: "Insulin-like growth factor-I messenger RNA content in the oviduct of Japanese quail(Coturnix coturnix japonica):changes during growth and development or after estrogen" Compt.Biochem.Physiol.109C. 191-204 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] KIDA,S.,NOGUCHI,T.,et al.: "Effects of insulin-like growth factor-I,estrogen,glucocorticoid and transferrin on the mRNA contents of ovalbumin and conalbumin in primary cultures of quail(Coturnix coturnix japouica)" Compt.Biochem.Physiol.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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