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Modification of T cell responses by Eta-1 and pathogenesis of autoimmune disease.

Research Project

Project/Area Number 06454189
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionHokkaido Universitiy

Principal Investigator

UEDA Toshimitsu  Hokkaido University Institute of Immunological Science Professor, 免疫科学研究所, 教授 (00160185)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥5,200,000 (Direct Cost: ¥5,200,000)
KeywordsEta-1 / RGD / Cell Binding Site / Integrin / 細胞接着部位 / Tリンパ球 / 自己免疫 / サイトカイン
Research Abstract

Previously, Eta-1 was shown to contain RGD tripeptide sequence that can interact with cell surface receptor, alpha_vbeta_3 integrin. In order to determine whether Eta-1 possesses an additional cell binding site within molecule, we generated various forms of recombinant Eta-1. We then tested the binding of B16-BL6, B16-F10 and L929 cells to various Eta-1. We found that non-RGD domains of Eta-1 promote cell adhesion without involving alpha_v integrin. New cell binding sites were located in both N-terminal and C-terminal halves of Eta-1 molecule. We also found taht receptors for new cell binding sites were expressed by only B16-BL6 cells, but not by B16-F10 and L929 cells.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Mori,K.: "In vivo cytokine gene expression in various T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse." Autoimmunity.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirasawa,M.: "Integrin expression and ability to adhere to extra-cellular matrix proteins and endothelial cells in human lung cancer lines." Br.J.Cancer.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katagiri,Y.: "Functional analysis of osteopontin molecule." Ann.N.Y.Acad.Sci.760. 371-374 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katagiri,Y.: "Non-RGD domains of osteopontin promote cell adhesion without involving α_v integrins." J.Cellular Biochemistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mori, K., Kobayashi, S., Inobe, M., Jia, W.Y., Tamakoshi, M., Miyazaki, T.and Ueda, T.: "In vivo cytokine expression in various T cell subsets of the autoimmune MRL/Mp-lpr/1pr mouse." Autoimmunity. 17. 49-57 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirasawa, M., Shijubo, N., Ueda, T.and Abe, S.: "Integrin expression and ability to adhere to extracellular matrix proteins and endothelial cells in human lung cancer lines." Br. J.Cancer. 70. 466-473 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katagiri, Y., Mori, K., Hara, T., Tanaka, K., Murakami, M.and Ueda, T.: "Functional analysis of osteopontin molecule." Ann. N.Y.Acad. Sci.760. 371-374 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katagiri, Y., Murakami, M., Mori, K., Iizuka, J., Hara, T., Tanaka, K., Jia, W.Y., Chambers, A.F.and Ueda, T.: "Non-RGD domains of osteopontin promote cell adhesion without involving alphaV integrins." J.Cell. Biochem.(in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Katagiri,Y.: "Functional analysis of osteopontin molecule." Ann.N.Y.Acad.Sci.760. 371-374 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katagiri,Y.: "Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins." J.Cellular Biochemistry. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Mori,K.: "In vivo cytokine gene expression in various T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse." Autoimmunity. 17. 49-57 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirasawa,M.: "Integrin expression and ability to adhere to extracellular matrix proteins and endotherial cells in human lung cancerlines." Br.J.Cancer. 70. 466-473 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kijimoto-Ochiai,S.: "Demonstration of the interaction between the CD23 molecule and the garatose residue of glycoproteins." Immunology Letters. 40. 49-53 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kobayashi,M.: "Expression of adhesion molecule on human hematopoietic progenitor cells at different maturational stages." Stem Cells. 12. 316-321 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katagiri,Y.: "Functional analysis of osteopontin molecule." Ann.N.Y.Acad.Sci.(in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] 猪部 学: "細胞接着分子と細胞間相互作用" 臨床分子生物学. 特別号. 254-257 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 上出利光: "現代病理学大系6・免疫" 中山書店, 398 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 上出利光: "細胞接着分子" 中外医学社, 85 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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