Modification of T cell responses by Eta-1 and pathogenesis of autoimmune disease.
| Project/Area Number |
06454189
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido Universitiy |
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Principal Investigator |
UEDA Toshimitsu Hokkaido University Institute of Immunological Science Professor, 免疫科学研究所, 教授 (00160185)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | Eta-1 / RGD / Cell Binding Site / Integrin / 細胞接着部位 / Tリンパ球 / 自己免疫 / サイトカイン |
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| Research Abstract |
Previously, Eta-1 was shown to contain RGD tripeptide sequence that can interact with cell surface receptor, alpha_vbeta_3 integrin. In order to determine whether Eta-1 possesses an additional cell binding site within molecule, we generated various forms of recombinant Eta-1. We then tested the binding of B16-BL6, B16-F10 and L929 cells to various Eta-1. We found that non-RGD domains of Eta-1 promote cell adhesion without involving alpha_v integrin. New cell binding sites were located in both N-terminal and C-terminal halves of Eta-1 molecule. We also found taht receptors for new cell binding sites were expressed by only B16-BL6 cells, but not by B16-F10 and L929 cells.
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Report
(3 results)
Research Products
(18 results)
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[Publications] Mori, K., Kobayashi, S., Inobe, M., Jia, W.Y., Tamakoshi, M., Miyazaki, T.and Ueda, T.: "In vivo cytokine expression in various T cell subsets of the autoimmune MRL/Mp-lpr/1pr mouse." Autoimmunity. 17. 49-57 (1994)
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[Publications] Katagiri, Y., Mori, K., Hara, T., Tanaka, K., Murakami, M.and Ueda, T.: "Functional analysis of osteopontin molecule." Ann. N.Y.Acad. Sci.760. 371-374 (1995)
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[Publications] Katagiri, Y., Murakami, M., Mori, K., Iizuka, J., Hara, T., Tanaka, K., Jia, W.Y., Chambers, A.F.and Ueda, T.: "Non-RGD domains of osteopontin promote cell adhesion without involving alphaV integrins." J.Cell. Biochem.(in press.).
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Related Report
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