| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1995: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1994: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Research Abstract |
1) Influenza viruses isolated from equine which contains Neu5Gc species of the sialic acid on the epitherial cells in the trachea preferentially bind to the Neu5Gc-containing glycoproteins and glycolipids, whereas, the viruses isolated from human which contains only Neu5Ac species binds to Neu5Ac-glycolipids. These results indicate that influenza virus isolates recognize the same sialic acid species in the receptor glycoproteins and glycolipids, such as Neu5Ac (N-acetyl-neuraminic acid) and Neu5Gc (N-glycolylneuraminic acid) , and also influenza viruses may be selected by the receptor sialic acid species on the host cell membranes.
2) Influenza viruses which isolated from MDCK cells recognize Neu5Ac2-6Gal-sequence, however, some influenza viruses which isolated from embryonic eggs (including CAM culture) preferentially bind to Neu5Ac2-3Gal sequence, indicating that the viral selection may be occurred depending on the host cell embrane receptor terminal sialic acid linkages, such as Neu5Ac2-3, and Neu5Ac2-6.
3) We found the common structure of the influenza virus receptor sialosugar chains, which is not affected by the antigenic variation and host cell selection.
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