| Project/Area Number |
06454216
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Chiba University School of Medicine |
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Principal Investigator |
TANIGUCHI Masaru Chiba Univ.Sch Med.Professor, 医学部, 教授 (80110310)
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| Co-Investigator(Kenkyū-buntansha) |
KOSEKI Haruhiko Chiba Univ.Sch Med.Instructor, 医学部, 助手 (40225446)
KANNO Masamoto Chiba Univ.Sch Med.Assoc.Professor, 医学部, 助教授 (40161393)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1995: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1994: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | Autoimmune disease / Valpha14 NK T cells / AGM / Invariant Valpha14 / Extrathymic development / SLE / 胸腺外T細胞分化 / Vα14T細胞 / 胸腺外分化 / 均一な抗原受容体 / 胎児肝 / 受容体遺伝子再構成 |
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| Research Abstract |
We identified a novel subset of T cells, NK T cell. The NK T cells contain two distinct subsets : Valpha14NTCR^+ and Valpha14 TCR^-. Valpha14^+ NK T cells are characterized by the expression of an invariant TCRalpha encoded by Valpha14 Jalpha281 with a one-nucleotide N-region in association with Vbeta8.2 TCR.The majority of NK T cells in the periphery are Valpha14^+, while thymic NK T cells are Valpha14^-. Interestingly, only Valpha14^+ NK T cells are tightly correlated with autoimmune disease development. Moreover, Valpha14 NK T cells develop extrathmically before thymus formation at an early stages of embryogenesis, suggesting that Valpha14 NK T cells are distinct lineage from traditional T cells and control the immune system.
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