| Project/Area Number |
06454245
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Jichi Medical School |
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Principal Investigator |
YANAGAWA Hiroshi Jichi Med School, Dept of Public Health, Professor, 医学部, 教授 (30077169)
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| Co-Investigator(Kenkyū-buntansha) |
TANIHARA Shinichi Jichi Med School, Dept of Public Health, Senior Researcher, 医学部, 助手 (40285771)
NAKAMURA Yosikazu Jichi Med School, Dept of Public Health, Associate Professor, 医学部, 助教授 (50217915)
SAKATA Kiyomi Jichi Med School, Dept of Public Health, Assistant Professor, 医学部, 講師 (50225794)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | Kawasaki disease / Epidemiology / Long-term follow-up / Management / Cardiac sequelae / Mortality rates |
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| Research Abstract |
Objective : To determine whether the mortality rate of patients with a history of Kawasaki disease is higher than that of the general population.
Design : In a cohort study, 6576 patients with Kawasaki disease were observed from the first medical encounter because of the disease through the end of 1994, or until death. Standardized mortality ratios (SMR) with 95% confidence intervals (CI) were calculated with vital statistics data of Japan for the control.
Results : Of 6576 patients who met the eligibility criteria, 6550 (99.6%) were followed through either the end of the study or the date of death. Twenty patients (14 male subjects) died during the study period ; an overall SMR of 1.35 (95% CI,0.82 to 2.08) was calculated for the entire study period. The SMR was 1.45 (95% CI,0.79 to 2.44) for male subjects and 1.15 (95% CI,0.42 to 2.52) for female subjects. During the acute phase of the disease (the first 2 months after the first visit to hospitals), the SMR was higher, particularly in male subjects (SMR,10.13,95% CI,3.72 to 22.08). After the acute phase, however, both boys and girls had low SMRs. Nine of the 20 deaths were caused by Kawasaki disease ; there were 3 deaths as a result of congenital anomalies of the circulatory system and 2 subjects died of malignant neoplasms of lymphatic or hematopoietic tissues.
Conclusions : Although the mortality rate among those with a history of Kawasaki disease was elevated in Japan, many of the deaths that caused the elevation occurred during the acute phase of the disease. The mortality rate was not increased after the acute phase of the disease.
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