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The immunological analysis of the pathogenesis of psoriasis and its related disorders

Research Project

Project/Area Number 06454313
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTOHOKU UNIVERSITY SCHOOL,OF MEDICINE

Principal Investigator

TAGAMI Hachiro  Tohoku Univ. Sch of Med, Dermatology Professor, 医学部, 教授 (60026911)

Co-Investigator(Kenkyū-buntansha) TABATA Nibuko  Tohoku Univ Sch of Med, Dermatology Lecturer, 医学部付属病院, 助手 (00270835)
HORIUCHI Norihisa  Tohoku Univ Sch of Med, Dermatology Lecturer, 医学部付属病院, 助手 (20260432)
TERUI Tadashi  Tohoku Univ Sch of Med, Dermatology Associate Professor, 医学部付属病院, 講師 (30172109)
AIBA Setsuya  Tohoku Univ Sch of Med, Dermatology Associate Professor, 医学部, 講師 (80159269)
KATO Taizo  Tohoku Univ Sch of Med, Dermatology Assistant Professor, 医学部, 助教授 (20004898)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordspsoriasis / pustulosis / superantigen / Langerhans cell / complement / cytokine / signal transduction
Research Abstract

In psoriasis and sterile pustulosis, chemotactic peptides consisting of complement fragments and chemokines (IL-8 and Gro-alpha) are demonstrable in lesional skin. They are presumed to play an important role in the induction of leukocyte chemotaxis from the dermal papillae (squirting papillae). C3, the key factor in the complement system is produced by keratinocytes. We studied cytokine regulation of C3 production by cultured human keratinocytes with ELISA by adding IL-1 alpha, beta, -2,3,4,5,6,7,8,10, TNF-alpha INF-alpha and -gamma, and GMCSF to the cultures. Among them, INF-gamma and TNF-alpha induced the synthesis of C3 in a dose dependent manner. There was a remarkable synergistic effect between them. Further analysis of C3 production revealed that these cytokines augmented the C3 production by epidermal Keratinocytes via different signal transduction pathways. Langerhans cells, epidermal dendritic cells with antigen-presenting capacity

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Terui, T., Ya-Xian, Zhen, Kato, T., Tagami, H.: "Mechanism of human polymorphonuclear leukocyte adhension to serum-treated corneocytes." J Invest Dermatol. 104. 279-301 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Aiba, S., NAkagawa, S., Ozawa, H., Tagami, H.: "Different Expression of E-Cadherin by two cutaneous γ/8 TcR T-Cell Subsets, Vγ5^- and Vγ5^+ γ/8 TcR^+ T cells" J Invest Dermatol. 105. 379-382 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ozawa, H., Aiba, S., Tagami, H.: "Murine epidermal Langerhans cells express CD48, which is a counter-receptor for mouse CD2." Arch Dermatol Res. 287. 524-528 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshimura, T., Kudoh, K., Aiba., Tagami, H.: "Antiinflammatory effects of topical ketoconazole for the inflammation induced on the skin of harless guinea-pigs by repeated applications of heat-kolled spores of Malassezia furfur. A comparative study with hydrocortisone 17-butyrate." J Dermatol Treatment. 6. 113-116 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 田上八朗: "乾癬" 老年病診療Q & A. 23. 116-117 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Terui, T.et al: "Mechanism of human ply-morphonuclear leukocyte adhension to serum treated corneocytes" J Invest Dermatol. 104. 279-301 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Aiba, S.Et al: "Different Expression of E-Cadherin by two cutaneous TcR T-_Cell Subsets, Vgamma5 and Vgamma5^+gamma/g TcR^+ T cells" J Invest Dermatol. 105. 379-382 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ozawa, H.et al: "Murine epidermal Langerhans cells ecpress CD48, Which is a counter-re-ceptor for mouse CD2" Arch Dermatol Res. 287. 524-528 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshimura, T.et al: "Antiinflammatory effects of topical ketoconazole for the inflammation induced on the skin of hairless guinea-pigs by repeated applications of heat-kolled spores of Malassezia furfur. A comparative study with hydrocortisone 17-butyrate" J Dermatol Treatment. 6. 113-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Terui,T.,Ya-xian,Zhen,Kato,T.,Tagami,H.: "Mechanism of human polymorphonuclear leukocyte adnension to serum-treated corneocytes." J Invest Dermatol. 104. 279-301 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Aida,S.,Nakagawa,S.,Ozawa,H.,Tagami,H.: "Different Expression of E-Cadherin by two cutaneous γ/δ TcR T-Cell^- Subsets,Vγ5^- and Vγ5^+ γ/δ TcR^+ T cells" J Invest Dermatol. 105. 379-382 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ozawa,H.,Aida,S.,Tagami,H.: "Murine epidermal Langerhans cells express CD48,which is a counter-receptor for mouse CD2." Arch Dermatol Res. 287. 524-528 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshimura,T.,Kudoh,K.,Aida.,Tagami,H.: "Antiinflammatory effects of topical ketoconazole for the inflammation induced on the skin of harless guinea-pigs by repeated applicaions of heat-kolled spores of Malassezia furfur.A comparative study with hydrocortisone 17-butyrate." J Dermatol Treatment. 6. 113-116 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 田上八朗: "乾癬" 老年病診療Q&A. 23. 116-117 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takematsu,H.Tagami,H.: "Lack of Correlation between interleukin 6 and interleukin 1 levels in psoriatic lesional skin ." Tohoku J Exp Med. 172. 243-252 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takematsu,H.,Takahashi,K.,Tagami,H.: "Systemic tumour necrosis factor(TNF)treatment in psoriasis." J Dermatol Treat. 5. 133-137 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Terui,T.,Ya-Xian,Zhen,Kato,T.,Tagami H.: "Mechanism of human polymorphonuclear leukocyte adhesion to serum-treated corneocytes." J Invest Dermatol. 104. 297-301 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tagami,H.: "Psoriasis" Ed.Louis Dubertret ISED Publishing, 7 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tagami,H.: "Psoriasis" Ed.Louis Dubertret ISED Publishing, 7 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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