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The roles of vitamin D and growth factors in the pathogenesis of renal osteodystrophy

Research Project

Project/Area Number 06454353
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

SEINO Yoshiki  Okayama University Medical School Professor, 医学部, 教授 (80028620)

Co-Investigator(Kenkyū-buntansha) MORIWAKE Tadashi  Okayama University Hospital Assistant Professor, 医学部・附属病院, 助手 (40243505)
TANAKA Hiroyuki  Okayama University Hospital Assistant Professor, 医学部・附属病院, 助手 (80231413)
KANZAKI Susumu  Okayama University Hospital Assistant Professor, 医学部・附属病院, 講師 (90224873)
久保 俊英  岡山大学, 医学部・附属病院, 助手 (50252961)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥6,600,000 (Direct Cost: ¥6,600,000)
Keywordsvitamin D receptor / gene polymorphism / secondary hyperparathyroidism / 骨密度 / ビタミンD受容体(VDR) / IGF結合蛋白(IGFBP) / 2次性副甲状腺機能亢進症(2゚HPT) / 腎性骨異栄養症(ROD)
Research Abstract

To clarify the pathophysiologic roles of vitamin D in the renal osteodystrophy, the expression of vitamin D receptor (VDR) gene in parathyroid gland was examined. Decreased expression of VDR was confirmed by immunostaining and in situ hybridization methods. From these results in hands, we next turned to examine the VDR gene polymorphism in renal failure, because Eisman et al.suggested that VDR gene polymorphism might determine VDR mRNA stability. Namely, the genotype which contains Bsml and Apal cutting sites in intron 8 (referred to as B and A respectively), and does not contain Taql cutting site (t) in exon 9 might be unstable. In chronic renal failure patients, the patients who had B,A,t genotype showed more sever from of secondary hyperparathyroidism. Therefore, the severities of secondary hyperparathyroidism may be forecasted by the analysis of VDR gene polymorphism.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] T. Yamate: "Bone-Forming Ability of 24R, 25-Dihydroxyvitamin D3 in the Hypophosphatemic Mouse." Journal of Bone and Mineral Research. 9. 1967-1974 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S. Kanzaki: "Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 protease." Endocrinology. 134. 383-392 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S. Wei: "A Multiple Assay for Vitamin D Metabolites without High-Performance Liquid Chromatography." Analytical Biochemistry. 222. 359-365 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S. Fujimoto: "Urinary Pyridinoline and Deoxypyridinoline in Healthy Children and in Children with Growth Hormone Deficiency." Journal of Clinical Endocrinology and Metabolism. 80. 1922-1928 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Kubo: "Serum levels of carboxyterminal propeptide of type 1 procollagen and pyridinoline crosslinked telopeptide of type I collagen in normal children and children with GH deficiency during GH therapy." Bone. 17. 397-401 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Yamate: "Bone-Forming Ability of 24R,25-Dihydroxy-Vitamin D3 in the Hypophosphatemic Mouse. Patterns of Osteocalcin and its Propeptide." Journal of Bone and Mineral Research. 9. 1967-1974 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Kanzaki: "Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 protease." Endocrinology. 134. 383-392 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Wei: "A Multiple Assay for Vitamin D Metabolite without High-Performance Liquid Chromatography." Analytical Biochemistry. 222. 359-365 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Fujimoto: "Urinary Pyridinoline and Deoxypyridinoline in Healthy Children and in Children with Growth Hormone Deficiency." Journal of Clinical Endocrinology and Metabolism. 80. 1922-1928 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kubo: "Serum levels of carboxyterminal propeptide of type I procollagen and pyridinoline crosslinked telopeptide of type I collagen in normal children and children with GH deficiency during GH therapy." Bone. 17. 397-401 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Fujimoto: "Urinary Pyridinoline and Deoxypyridinoline in Healthy Children and in Children with Growth Hormone Deficiency." Journal of Clinical Endocrinology and Metabolism. 80. 1922-1928 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Kubo: "Serum levels of carbocyterminal propeptide of type I procollagen and pyridinoline crosslinked telopeptide of type I collagen in normal children and children with CH deficiency furing GH therapy." Bone. 17. 397-401 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Yamate: "Bone-Forming Ability of 24R,25-Dihydroxyvitamin D_3 in the Hypophosphatemic Mouse." Journal of Bone and Mineral Research. 9. 1967-1974 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Kanzaki: "Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases." Endocrinology. 134. 383-392 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Watanabe: "1,25-Dihydroxyvitamin D radioreceptor assay using bovine mammar grand receptor and non-high performance liquid chromatographic" Clinica Chimica Acta. 225. 187-194 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Wei: "A Multiple Assay for Vitamin D Metabolites without High-Performance Liquid Chromatography." Analytical Biochemistry. 222. 359-365 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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