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Percutaneous chemoperfusion with complete venous isolation and charcoal hemoperfusion for treatment of abdominal cancer

Research Project

Project/Area Number 06454386
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKOBE UNIVERSITY

Principal Investigator

GU Eisei  Kobe University School of Medicine, First Department of Surgery, Associate Professor, 医学部附属病院, 講師 (40195615)

Co-Investigator(Kenkyū-buntansha) SAITOH Yoichi  Kobe University School of Medicine, First Department of Surgery, Professor, 医学部附属病院, 教授 (90004803)
TOMINAGA Masahiro  Kobe University School of Medicine, First Department of Surgery, Medical Staff, 医学部附属病院, 医員
KURODA Yoshikazu  Kobe University School of Medicine, First Department of Surgery, Associate Profe, 医学部附属病院, 助教授 (70178143)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsPercutaneous isolated organ chemoperfusion / Venous isolation and charcoal hemoperfusion / High-dose chemotherapy / 肝細胞癌 / 骨盤腫瘍 / 子宮癌 / 肝潅流化学療法 / 肝癌
Research Abstract

We developed a new treatment system for high-dose intraarterial chemotherapy with complete venous isolation and charcoal hemoperfusion in an attempt to maximize tumor drug delivery and, at the same time, to minimize systemic toxicity. This study was designed to develop multimodal treatment strategies for malignant abdominal tumors in the liver, the pancreas, and the pelvis. In the first year, we established a single catheter technique of percutaneous isolated liver chemoperfusion (PILP) and initiated a clinical trial of repeated treatment on the same patient. Our findings clearly showed that repeated treatments further expand the therapeutic index of this treatment for malignant liver tumors. On the other hand, we initiated the phase II clinical trial of pelvic chemoperfusion with infrarenal inferior vena caval isolation and charcoal hemoperfusion (IVCI・CHP) for advanced uterine cancer. In addition, we completed an experimental study on portal venous isolation and charcoal hemoperfusio … More n for pancreatic cancer. In the second vear, we introduced a new treatment protocol combining repeated PILP as the inductive therapy with low-dose intermittent infusions as the maintenance therapy for patients with advanced hepatoccellular carcinoma. For IVCL・CHP,a protocol of neoadjuvant chemotherapy was designed to achieve down-staging of advanced uterine cancer. Three patients with uterine cancer have been treated with this protocol. One patient had a complete tumor necrosis, as proved microscopically after operation, and two had a partial response. Thus we confirmed the efficacy of this treatment for pelvic tumors. In the third year, we attempted to treat pancreatic tumor with this treatment.
However, we could not have patients with indication for the treatment. In patients with advanced hepatocellular carcinoma, we assessed the long-term results of the multimodal treatment with use of PILP.The results indicated that 5-year survival rate reached 40% and that 4 of 30 patients had a long-term tumor-free survival in a range of 2 to 4 years. We have also treated 15 patients with colorectal hepatic metastases, and have shown the efficacy of PILP for the disease. Based on these results, we concluded that our method offers an effective therapeutic option for patients with malignant abdominal tumors. Less

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Y. Ku.: "Extracorporeal carbon chemofiltration under hepatic venous isolation for high-dose intraartcrial chemotherapy of the liver." Surgery. 116. 941 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Ku.: "Direct hemoperfusion under infrahepatic inferior vena caval isolation for the intraarterial chemotherapy of pelyic tumors." Surgery Today. 24. 1031-1033 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Ku.: "Clinical pilot study on high-dose intraarterial chemotherapy with direct hemoperfusion under hepatic venous isolation in patients with advance hepatocellular carcinoma." Surgery. 117. 510-519 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Ku.: "Percutaneous technique of hepatic venous isolation and charcoal hemoperfusion with a dual-ballon vena cava catheter." Surgery. 119. 360 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Ku.: "Percutaneous hepatic venous isolation and extracorporeal charcoal hemoperfusion for high-dose intraarterial chemotherapy in patients with colorectal hepatic metastases." Surgery Today. 26. 305-313 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Ku.: "Single catheter technique of hepatic venous isolation and charcoal hemoperfusion for malignant liver tumors." Am J Surg. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Extracorporeal carbon chemofiltration under hepatic venous isolation for high-dose intraarterial chemotherapy of the liver." Surgery. 116. 941 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Direct hemoperfusion under infrahapetic inferior vena caval isolation for the intraarterial chemotherapy of pelvic tumors." Surgery Today. 24. 1031-1033 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Clinical pilot study on higy-dose intraarterial chemotherapy with direct hemoperfusion under hepatic venous isolation in patients with advanced hepatocellular carcinoma." Surgery. 117. 510-519 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Percutaneous technique of hepatic venous isolation and charcoal hemoperfusion with a dual-balloon vena cava catheter." Surgery. 119. 360 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Percutaneous hepatic venous isolation and extracorporeal charcoal hemoperfusion for high-dose intraarterial chemotherapy in patients with colorectal hepatic metastases." Surgery Today. 26. 305-313 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku: "Single catheter technique of hepatic venous isolation and charcoal hemoperfusion for malignant liver tumors." Am J surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tominaga: "Pharmacologic evaluation of portal venous isolation and charcoal hemoperfusion for high-dose intraarterial chemotherapy of the pancreas." Br J Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Ku.: "Extracorporeal carbon chemofiltration under hepatic venous isolation for high-dose intraarterial chemotherapy of the liver." Surgery. 116. 941- (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Ku.: "Direct hemoperfusion under infrahepatic inferior vena caval isolation for the intraarterial chemotherapy of pelvic tumors." Surgery Today. 24. 1031-1033 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Ku.: "Clinical pilot study on high-dose intraarterial chemotherapy with direct hemoperfusion under hepatic venous isolation in patients with advance hepatocellular carcinoma." Surgery. 117. 510-519 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Ku.: "Percutaneous technique of hepatic venous isolation and charcoal hemoperfusion with a dual-balloon vena cava catheter." Surgery. 119. 360- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Ku.: "Percutaneous hepatic venous isolation and extracorporeal charcoal hemoperfusion for high-dose intraarterial chemotherapy in patients with colorectal hepatic metastases." Surgery Today. 26. 305-313 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Ku.: "Single catheter technique of hepatic venous isolaiton and charcoal hemoperfusion for malignant liver tumors." Am J Surg. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Y. Ku: "Single catheter technique of hepatic venous isolation and extracorporeal charcoal hemoperfusion for malignant liver tumors" Am J Surg. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ku: "Percutaneous technique of hepatic venous isolation and charcoal hemoperfusion with a dual-baloon vena cava catheter" Surgery. (in press). (1966)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ku: "Clinical pilot study on high-dose intraarterial chemotherpy with direct hemoperfusion under hepatic venous isolation in patients with advanced hepatocellular carcinama" Surgery. 117. 510-519 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ku: "Extracorporeal carbon chemofiltration under hepatic venous isolation for high-dose intraarterial chemotherapy of the liver" Surgery. 116. 941 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Ku: "Percutaneous hepatic venous isolation and extracorporeal charcoal hemoperfusion for high-dose intraarterial chemotherapy in patients with colorectal hepatic metastases" Surgery. Today. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 富永正寛,具英成,斉藤洋一: "肝細胞癌肝切除後再発例に対する経皮的HVI・DHP大量肝動注療法を軸とした治療の工夫-再発形式からみたTAE療法との比較" 日本消化器外科学会雑誌. 27. 2322-2326 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y,Ku(=Eisei Gu): "Extracorporeal carbon chemofiltration under hepatic venous isolation for high-dose intratcrial chemotherapy of the liver" SURGERY. 116. 941 (1994-)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Ku: "Direct hemoperfusion under infratuepatic inferior vena caval isolation for the intraarterial chemotherapy of pelvic tumors" SURGERY Today. 24. 1031-1033 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Ku: "Clinical pilot study on high-dose intraarterial chemothepapy using direct hemoperfusion under hcpatic vanous isolation in patients with advanced hepatocellubr" SURGERY. 117(in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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