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Promotion of regeneration of remnant pancreas after pancreatectomy and modification of pylorus-preserving procedure

Research Project

Project/Area Number 06454387
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Takashi  Yamaguchi University, Faculty of Medicine, Professor, 医学部, 教授 (20026834)

Co-Investigator(Kenkyū-buntansha) HAYASHI Hiroto  Yamaguchi University, Faculty of Medicine, Lecturer, 医学部・附属病院, 助手 (60218592)
TANGOKU Akira  Yamaguchi University, Faculty of Medicine, Lecturer, 医学部, 助手 (10197593)
HAMANAKA Yuichiro  Yamaguchi University, Faculty of Medicine, Assistant Professor, 医学部・附属病院, 講師 (40189618)
OKA Masaaki  Yamaguchi University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (70144946)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1995: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1994: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsPancreatectomy / Protease inhibitor / Pancreatic regeneration / Gastric emptying / Pancreatic cancer / Neural and nodal dissection / Superior mesenteric artery / Pylorus preserving pancreatoduodenectomy / 膵退縮 / 膵栄養効果 / 膵機能不全 / 膵DNA量 / 膵重量 / リンパ節転移 / 神経叢浸潤 / 郭清 / 消化吸収障害 / 上腸間膜動脈
Research Abstract

1.Examination was made of the reversibility of pancreatic changes induced by the protease inhibitor (P.I.) in remnant pancreas after partial pancreatectomy in rats. Forty male Wistar rats were grouped as group I treated with water after laparotomy, group I treated with P.I.after laparotomy, group II treated with water after pancreatectomy and group IV treated with P.I.after pancreatectomy. In groups II and IV,camostat (200mg/kg/day) was administered daily for seven days via an orogastric tube. In groups II and IV,66% distal pancreatectomy was conducted, in which gastric and splenic segments were removed. Significant increase in pancreatic weight and tissue protein content and hypertrophy of the acinar cells of the pancreas was noted after P.I.administration. In group IV,increase in these parameters was greater and persisted for four weeks after the cessation of P.I.treatment. In group II,tyophic change was reversible and rapidly ceased within seven days after the last P.I.treatment. P. … More I.-induced trophic effect may thus be concluded greater and more prolonged in remnant that in normal pancreas.
2.We investigated the effect of dividing the pyloric branch of the vagus nerve and transection of the duodenum on gastric emptying using the acetaminophen method in rats to investigate the etiology of early delayd gastric emptying after pylorus preserving pancreatoduodenectomy (PPPD). The animals were divided into the following four groups. 1, group C ; shame operation, 2, group N ; division of the pyloric branch of the vagus nerve, 3, group D ; transection of the duodenum, and 4, group N+D ; pyloric denervation and doudenal transection. We traced the serial changes in gastric emptying in the four groups at 1,2 and 4 weeks after operations and compared the results. As a result, division of the neurovascular supply to the pylorus and/or transection of the duodenum, that were brought about during PPPD,caused postoperative delayd gastric emptying, which did, however, subsequently recover.
3.We examined the extent to which regional lymph nodes may be dissected while preserving the superior mesenterc nerve plexus (PLsma) in PPPD for periampullary cancer. The lymph nodes were distributed uniformly on the right and left hemicircles of the superior mesenteric artery (SMA) and along its longitudinal axis. Of a total of 142 lymph nodes, 134 (94.4%) were located outside the PLsma. Dissection of the superior mesenteric lymph nodes is theoretically to be possible while preserving the supperior mesenteric nerve plexus. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Suzuki T: "Pylorus-preserving pancreatoduodenectomy in Japan" J. Hep. Bil. Pancr. Surg.1. 379-384 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hamanaka Y, Suzuki T: "Total pancreatic duct drainage for leakproof pancreatojejunostomy" Surgery. 115. 22-26 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishikawa M, Suzuki T: "Gastric pH monitoring after pylorus preserving pancreaticoduodenectomy with Billroth I type of reconstruction" J. Amer. Coll. Surgeons. 172. 129-134 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamamoto S, Suzuki T: "Adenocarcinoma of the pancreas accompanied by pancreatic abscess" Pancreas. 10. 104-107 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suga K, Suzuki T: "Thallium-201 SPECT and technetium-99m-phytate subtraction liver imaging in the evaluation of pancreatic cancer" J. Nucl. Med.36. 762-770 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ueno T, Suzuki T: "A proposal mechanism of early delayed gastric emptying after pylorus preserving pancreatoduodenectomy" Hepato-Gastroenterology. 42. 269-274 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 鈴木 敞: "消化器病学第4版(分担)" 医学書院, 500 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 上野富雄、鈴木 敞ほか: "膵頭十二指腸切除術の適応と術式の要点(分担)" 医学図書出版, 376 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suzuki T et al: "Pylorus-preserving pancreatoduodenectomy in Japan : history and present status" J.Hep.Bil.Pancr.Surg.1. 379-384 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Oka M,Suzuki T et al: "Adoptive immunotherapy for unresectable or recurrent pancreatic cancer using lymphokine-activated killer cells or cytotoxic T cells" J.Hep.Bil.Pancr.Surg.1. 163-167 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hamanaka Y,Suzuki T: "Total Pancreatic duct drainage for leakproof pancreatojejunostomy" Surgery. 115. 22-26 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishikawa M,Suzuki T et al: "Gastric pH monitoring sfter pylorus preserving pancreatoduodenectomy with Billroth I type of reconstruction" J.Am.Coll.Surgeons. 172. 129-134 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamamoto S,Suzuki T et al: "Adenocarcinoma of the pancreas accompanied by pancreatic abscess" Pancreas. 10. 104-107 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hamanaka Y,Suzuki T: "Modified dunking pancreatojejunostomy for a soft pancreas" Brit.J.Surg.82. 404-405 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ueno T,Suzuki T et al: "Serum drug concentrations after oral administration of paracetamol to patients with surgical resection of the gastrointestinal tract" Brit.J.Clin.Pharmac.39. 330-332 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suga K,Suzuki T et al: "Thallium-201 SPECT and technetium-99m-phytate subtraction liver imaging in the evaluation of pancreatic cancer" J.Nucl.Med.36. 762-770 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamamoto T,Suzuki T et al: "Bile acids and microorganisms in the jejunal lumen after biliary reconstruction in dogs" J.Am.Coll.Surgeons. 181. 525-529 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ueno T,Suzuki T et al: "A proposal mechanism of early dalayd gastric emptying after pylorus preserving pancreatoduodenectomy" Hepato-Gastroenterology. 42. 269-274 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamamoto S,Suzuki T: "Adenocarcinoma of the pancreas accompanied by pancreatic abscess" Pancreas. 10. 104-107 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hamanaka Y,Suzuki T: "Modified dunking pancreatojejunostiomy for a soft pancreas" Brit.J.Surg.82. 404-405 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ueno T,Suzuki T: "Serum drug concentration of paracetamol to patients with surgical resecton of the gastrointestinal tract" Brit.J.Clin.Pharmac.39. 330-332 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suga K,Suzuki T: "Thallium-201 SPECT and technetium-99m-phytate subraction liver imaging in the evaluation of pancreatic cancer" J.Nucl.Med.36. 770-762 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamamoto T,Suzuki T: "Bile acids and microorganisms in the jejunal lumen after biliary reconstruction in dogs" J.Am.Coll.Surgeons. 181. 525-529 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ueno T.Suzuki T: "A proposal mechanism of early delayed gastric emptying after pylorus preserving pancreatoduodenectomy" Hepato-Gastroenterology. 42. 269-274 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鈴木 敞: "消化器病学第4版(分担)" 医学書院, 500 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 上野富雄、鈴木 敞ほか: "膵頭十二指腸切除術の適応と術式の要点(分担)" 医学図書出版, 376 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suzuki,T: "Pylorus-preserving pancreatoduodenectcmy in Japan:history and present status" J.Hep.Bil.Pancr.Surg.1. 379-384 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamamoto,S: "Adenocarcinoma of the pancreas accompanied by pancreatic abscess." Pancreas. 10. 104-107 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hamanaka,Y: "Total pancreatic duct drainage for leakproof pancreatojejunostomy." Surgery. 115. 22-26 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Oka,M: "Adoptive immunotherapy for unresectable or recurrent pancreatic cancer" J.Hep.Bil.Pancr.Surg.1. 163-167 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishikawa,M: "Gastric pH monitoring after pylorus preserving pancreatoduodenectomy with Billroth I type of reconstruction." J.Amer.Coll.Surgeons. 172. 129-134 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hamanaka,Y: "Ganglioside antigen of DU-PAN-2 in a human pancreatic cancer." FEBS Letters. 353. 48-52 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,T: "Pitfalls and Complications in the Diagnosis and Management of Hepatobiliary and Pancreatic Diseases" Georg Thieme Verlag, 537 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鈴木 敞: "消化器外科学" 朝倉書店, 495 (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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