| Project/Area Number |
06454389
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | The Jikei University School of Medicine |
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Principal Investigator |
KASHIWAGI Hideyuki The Jikei University School of Medicine, Department of Surgery (II), Lecture, 医学部・外科学講座第2, 講師 (40185757)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUU Kin The Jikei University School of Medicine, Department of Surgery (II), Assistant, 医学部・外科学講座第2, 助手 (20266612)
MORIYA Yuusuke The Jikei University School of Medicine, Department of Surgery (II), Assistant, 医学部・外科学講座第2, 助手 (20256457)
AOKI Teruaki The Jikei University School of Medicine, Department of Surgery (II), Chief profe, 医学部・外科学講座第2, 教授 (20056708)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | Lower esophageal sphincter / Cardia / Reflux esophagitis / Hiatal Hernia / Fundoplication / Vector Volume / Yield Pressure |
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| Research Abstract |
Insulin-stimulated acid secretions were evaluated in 8 healthy volunteers and 5 reflux esophagitis patients. Acid secretions of reflux esophagitis patients were lower than those of healthy volunteers, but gastrin response was same in both groups. Yield pressure and vector volume were measured in 11 healthy voluteers and 8 reflux esophagitis patients. Computerized axial manometry was performed with a perfused catheter system that was drawn through the LES high pressure zone at a constant speed (1.0cm/sec). The catheter was attached to a transducer that recorded pressure at eight points of the circumference. The vector volume was calculated as the sum of areas of a series of irregular polygonal segments of the sphincter. The yield pressure of the cardia was calculated as the difference between the mean gastric pressures after and before the insufflation of 1000ml air into the stomach. The yield pressure and the vector volume was lower in reflux patients than in healthy volunteers, but the vector volume was more useful for assessment of the competence of the cardia. The vector volume was significantly increased after fundoplications. The vector volume of the patient who complained dysphagea was too high, and the insufficient result of antireflux surgery showed low value of the vector volume. The shape of vector volume was also important in evaluating the competence of the cardia. The vector volume seems to be useful for evaluating the function of cardia in reflux disease, particularly after antireflux surgery, but further investigations were needed.
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