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Surgical Treatment of Chronic Pulmonary Thromboembolism (c-PTE) and the Trial to make an animal model of c-PTE with beagle

Research Project

Project/Area Number 06454396
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

NAKAJIMA Nobuyuki  Chiba univ.school of medicine, professor, 医学部, 教授 (40241947)

Co-Investigator(Kenkyū-buntansha) MOGI Kenji  Chiba univ.school of medicine, medical staff, 医学部附属病院, 医員
KITO Hiroyuki  Chiba univ.school of medicine, assistant, 医学部附属病院, 文部教官(助手) (40261903)
NAKAYA Mitsuru  Chiba univ.school of medicine, assistant, 医学部附属病院, 文部教官(助手) (60261921)
MASUDA Masahisa  Chiba univ.school of medicine, lecturer, 医学部附属病院, 文部教官(講師) (50157210)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsCHRONIC PULMONARY THROMBOEMBOLISM / SURGICAL TREATMENT / INTRAVASCULAR OPTICAL FIBERSCOPE / ANIMAL MODEL OF PULMONARY THROMBOEMBOLISM / 実験モデル犬 / 外科治療成績 / セラミック・ビーズ
Research Abstract

(1)Clinical Investigation :
1.Result of surgical treatment for c-PTE patients. 25 patients of c-PTE were surgically treated in our hospital. 4 patients were dead during postoperative 30 days. The mortarity is 16.0%. But the other patients were obviously improved. The arterial blood gas in room air, cardiac index, mean-pulmonary arterial pressure and pulmonary vascular resistance are improved after operaton. The NYHA classifications of postoperative days are better than that of preoperative in 18 patients. They are in the NYHA 1 or 2.
2.Selection of Surgical approach to pulmonary artery. We have two ways of approach to arrive at pulmonary artery, Through Median Approach and Through Lateral Thoracotomy Approach. We investigate the difference of postoperative results through median approach from through lateral thoracotomy approach.
3.Pathological study of the specimen from patients'pulmonary artery during operation. We find that the specimens is classified into two kinds of character, firm … More and fragile. This character is very important for selective of approach during operation.
4.We used the intravascular optical fiber scope. It is very useful to confirm back flow from distal pulmonary artery after thromboembolecty in c-PTE patients.
(2)Trial to make an animal model of c-PTE with beagle :
We give the Tranexamic acid to dogs, make thrombus in inferior vena cava of the dogs, and blow off it to pulmonary artery. So that we try to make a model of c-PTE.But we can't make that model. It is very difficult. We choose new method to make it. Now Dr.Masuda is staying at San Diego in U.S.A.and he is learning it from the pulmonary medical staff of the University of California, San Diego.
(Summary) The surgical treatment of c-PTE is very useful. The quolity of life (QOL) of postoperative patients is better than that of preoperative. But we are not satisfied with that. The experiment of c-PTE is very important to understand the disease better, so that we want to make an animal model of c-PTE. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 中島伸之: "肺動脈塞栓症" 胸部外科. 48. 51-61 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 中川康次: "慢性肺塞栓症に対する手術治療" 静脈学. 6. 21-30 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増田政久: "慢性肺動脈血栓塞栓症の手術経験" Therapeutic Research. 16. 1322-1323 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 増田政久: "肺血栓塞栓症の治療法の選択はどうあるべきか? 外科の立場から" 血栓と循環. 3. 190-192 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakajima, N.: "Pulmonary thromboembolism." Kyoubu Geka. 48. 51-61 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nakagawa, Y.: "Surgical Treatment for Chronic Pulmonary Thromboembolism." Jomyaku-gaku. 6. 21-30 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masuda, M.: "The Experience of operation for Chronic Pulmonary Thromboembolism." Thrapeutic Research. 16. 1322-1323 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masuda, M.: "The Selection of treatment for Pulmonary Thromboembolism. From surgeon." Kessen to Junkan. 3. 190-192 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 中島伸之: "肺動脈塞栓症" 胸部外科. 48. 51-61 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中川康次・増田政久: "慢性肺動脈血栓塞栓症の手術治療" 静脈学. 6. 21-30 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田政久.他: "慢性肺塞栓症に対する手術経験" Theropeutic Research. 16. 1322-1323 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田政久・中島伸之: "肺血栓塞栓症の治療法の選択はどうあるべきか?外科の立場から." 血栓と循環. 3. 190-192 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 増田政久・茂木健司他: "肺塞栓症の凝固能と外科手術に関する検討" 厚生省特定疾患難治性・血管炎調査研究班 1994年度 研究報告書. 197-198 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中島伸之: "肺動脈塞栓症" 胸部外科. 48. 51-61 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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